Preparation and Characterization of ZnS: Mn Nanoparticles with Theoretical Analysis

Elttayef, Abdulhussain K.; Mohammad, Rajaa K.; Hammdi, Rabi N.; A.Khudhair, Baydaa

doi:10.14704/nq.2020.18.6.nq20177

Cited by 1 publication

(1 citation statement)

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“…The ionic gelation method is one of the recently distinguished techniques to prepare polymeric nanoparticles with hydrophilic drugs owing to its relative simplicity, efficiency, and better encapsulation efficiency (EE). In addition, CS is a naturally occurring polycationic polymer with glucosamine and N-acetyl glucosamine entities that blend well with anionic Poly (ε-caprolactone), forming an interfacial coacervate complexation by cross-linking [ 24 ] (as shown in Figure 10 ). For the preparation of APO-NPs, a CS (1–3%) solution with glacial acetic acid was prepared via constant overnight stirring at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective Ability of Apocynin Loaded Nanoparticles (APO-NPs) as NADPH Oxidase (NOX)-Mediated ROS Modulator for Hydrogen Peroxide-Induced Oxidative Neuronal Injuries

et al. 2021

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Apocynin (APO) is a known multi-enzymatic complexed compound, employed as a viable NADPH oxidase (NOX) inhibitor, extensively used in both traditional and modern-day therapeutic strategies to combat neuronal disorders. However, its therapeutic efficacy is limited by lower solubility and lesser bioavailability; thus, a suitable nanocarrier system to overcome such limitations is needed. The present study is designed to fabricate APO-loaded polymeric nanoparticles (APO-NPs) to enhance its therapeutic efficacy and sustainability in the biological system. The optimized APO NPs in the study exhibited 103.6 ± 6.8 nm and −13.7 ± 0.43 mV of particle size and zeta potential, respectively, along with further confirmation by TEM. In addition, the antioxidant (AO) abilities quantified by DPPH and nitric oxide scavenging assays exhibited comparatively higher AO potential of APO-NPs than APO alone. An in-vitro release profile displayed a linear diffusion pattern of zero order kinetics for APO from the NPs, followed by its cytotoxicity evaluation on the PC12 cell line, which revealed minimal toxicity with higher cell viability, even after treatment with a stress inducer (H2O2). The stability of APO-NPs after six months showed minimal AO decline in comparison to APO only, indicating that the designed nano-formulation enhanced therapeutic efficacy for modulating NOX-mediated ROS generation.

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Section: Methodsmentioning

confidence: 99%