Preparation and characterization of uniform-sized PLGA nanospheres encapsulated with oleic acid-coated magnetic-Fe 3 O 4 nanoparticles for simultaneous diagnostic and therapeutic applications

Mosafer, Jafar; Abnous, Khalil; Tafaghodi, Mohsen; Jafarzadeh, Hamed; Ramezani, Mohammad

doi:10.1016/j.colsurfa.2016.11.056

Cited by 47 publications

(21 citation statements)

References 28 publications

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“…A broad endotherm peak was observed around 350°C that corresponds to the complete degradation of surfactants. Thus, a mass loss using TGA demonstrated that magnetic emulsion was found to be composed of 75% of iron oxides and 25 wt.% oleic acid that remained bound to nanoparticles and could not be washed off [32].…”

Section: Tga Of Organic Ferrofluid and Magnetic Emulsionmentioning

confidence: 99%

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Khizar

Ahmad

Saleem³

et al. 2020

Advances in Polymer Technology

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A stable oil-in-water (O/W) magnetic emulsion was prepared by the emulsification of organic ferrofluid in an aqueous media, and its theranostic applications were investigated. The synthesis and characterization of the organic ferrofluid were carried out comprising of superparamagnetic maghemite nanoparticles with oleic acid coating stabilized in octane. Both exhibit spherical morphology with a mean size of 6 nm and 200 nm, respectively, as determined by TEM. Thermogravimetric analysis was carried out to determine the chemical composition of the emulsion. The research work described here is novel and elaborates the fabrication of thin-film gradients with 5, 10, 15, and 20 bilayers by layer-by-layer technique using polydimethyl diallyl ammonium chloride (PDAC) and prepared magnetic colloidal particles. The thin-film gradients were characterized for their roughness, morphology, and wettability. The developed gradient films and colloids were explored in magnetic resonance imaging (MRI) and hyperthermia. T1- and T2-weighted images and their corresponding signal intensities were obtained at 1.5 T. A decreasing trend in signal intensities with an increase in nanoparticle concentration in colloids and along the gradient was observed in T2-weighted images. The hyperthermia capability was also evaluated by measuring temperature rise and calculating specific absorption rates (SAR). The SAR of the colloids at 259 kHz, 327 kHz, and 518 kHz were found to be 156 W/g, 255 W/g, and 336 W/g, respectively. The developed magnetic combinatorial thin-film gradients present a significant potential for the future efficient simultaneous diagnostic and therapeutic bioapplications.

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Section: Tga Of Organic Ferrofluid and Magnetic Emulsionmentioning

confidence: 99%

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Khizar

Ahmad

Saleem³

et al. 2020

Advances in Polymer Technology

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“…In this study, we introduced an effective method for coencapsulation of SPIONs and Dox into the PLGA nanospheres via W 1 /O 1 , 2 /W 2 method. Based on our previous results, SPIONs showed a mean size of $20 nm with narrow particle size distribution [39]. In another study, we prepared NPs via W 1 /O 1 , 2 /W 2 method similar to this study except that we used PLGA-PEG-COOH instead of PLGA-PEG to conjugate the aptamer-NH 2 molecules, as a targeting ligand, on the surface of NPs via EDC/NHS technique [41].…”

Section: Diagnostic Applicationsmentioning

confidence: 89%

“…SPIONs were synthesized in our laboratory as described in the previously reported method [39]. Briefly, 4 ml of a NH 4 OH solution (5 M) was added to a deoxygenated solution of Fe (III) chloride (0.486 mg, 30 ml) and Fe (II) chloride (0.19 mg, 15 ml) over 2 min under nitrogen (N 2 ) atmosphere while stirring on a magnetic stir plate for 20 min.…”

Section: Synthesis Of Spionsmentioning

confidence: 99%

Comparative study of superparamagnetic iron oxide/doxorubicin co-loaded poly (lactic-co-glycolic acid) nanospheres prepared by different emulsion solvent evaporation methods

Mosafer

Teymouri

2017

Artificial Cells, Nanomedicine, and Biotechnology

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Poly (lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer for preparation of polymeric biodegradable carriers that shows attractive features and offers possibilities to tune the physicochemical characteristics, drug release properties and biological behaviour of the PLGA-based nanospheres. Double emulsion solvent evaporation methods fail when it comes to encapsulation of highly hydrophilic drugs such as doxorubicin (Dox). The reason for this defect is due to the rapid drug diffusion into the external aqueous phase before solidification of the PLGA nanospheres. In this study, we present a comprehensive comparison between the four different fabrication methods of PLGA nanospheres with a focus on double emulsion solvent evaporation-based methodologies to achieve the effective method for co-encapsulation of superparamagnetic iron oxide nanoparticles (SPIONs) and Dox into the PLGA polymer in terms of the size of nanoparticles, particle size distribution and drug loading. Therefore, the optimized ratio of the different phases and other process parameters of these methods is discussed. In conclusion, the prepared SPIO/Dox-PLGA nanospheres (NPs) via a modified double emulsion solvent evaporation method were found to be a promising delivery system in terms of particle size distribution, drug loading, release profile as well as magnetic properties for tumour therapeutic and diagnostic purposes.

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“…In recent years, innovative treatment approaches such as hyperthermia with gold nanoparticles, magnetic nanoparticles, and the combination of hyperthermia and chemotherapy are being investigated for improving patient's quality of life [ 54 ]. Magnetic nanoparticles are increasingly studied and exploited for their potential applications in cancer treatment [ 55 ]. Hyperthermia therapy is a medical treatment based on the exposure of body tissue to temperatures slightly higher than the physiological temperature (i.e., between 41°C and 46°C) to damage and kill cancer cells or to make them more susceptible to the effects of radiation and anticancer drugs.…”

Section: Development Of Magnetic Gel Composites For Hyperthermia Tmentioning

confidence: 99%

Recent Advances in Hydrogel-Based Drug Delivery for Melanoma Cancer Therapy: A Mini Review

Vishnubhakthula

Elupula

Durán-Lara

2017

Journal of Drug Delivery

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The purpose of this study is to describe some of the latest advances in using hydrogels for cancer melanoma therapy. Hydrogel formulations of polymeric material from natural or synthetic sources combined with therapeutic agents have gained great attention in the recent years for treating various maladies. These formulations can be categorized according to the strategies that induce cancer cell death in melanoma. First of all, we should note that these formulations can only play a supporting role that releases bioactive agents against cancer cells rather than the main role. This strategy involves delivering the drug via transdermal pathways, resulting in the death of cancerous cells. Another strategy utilizes magnetic gel composites to combat melanoma via hyperthermia therapy. This review discusses both transdermal and hyperthermia therapies and the recent advances that have occurred in the field.

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Preparation and characterization of uniform-sized PLGA nanospheres encapsulated with oleic acid-coated magnetic-Fe 3 O 4 nanoparticles for simultaneous diagnostic and therapeutic applications

Cited by 47 publications

References 28 publications

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Comparative study of superparamagnetic iron oxide/doxorubicin co-loaded poly (lactic-co-glycolic acid) nanospheres prepared by different emulsion solvent evaporation methods

Recent Advances in Hydrogel-Based Drug Delivery for Melanoma Cancer Therapy: A Mini Review

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