Preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment

Zhong, Jie; Shen, Zhigang; Yang, Yan; Chen, Jianfeng

doi:10.1016/j.ijpharm.2005.06.005

Cited by 78 publications

(37 citation statements)

References 20 publications

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“…Particle size reduction significantly improved dissolution rate. The lower crystallinity of the nanosuspension may also have contributed to the enhanced dissolution rate (23). We assumed that the increase in dissolution rate would improve the bioavailability.…”

Section: In Vitro Dissolution Testmentioning

confidence: 99%

The Preparation and Evaluation of Water-Soluble SKLB610 Nanosuspensions with Improved Bioavailability

et al. 2013

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Abstract. The aim of the study was to investigate the potential of nanosuspension to enhance the bioavailability of SKLB610 (Biopharmaceutical Classification System class II drug), a bioactive anticancer compound synthesized in our labs. SKLB610 nanosuspensions were prepared using wet media milling. Physicochemical characteristics of the nanosuspensions were evaluated, including particle size and distribution, dissolution, transmission electron microscopy, atomic force microscopy, thermogravimetric analysis, and X-ray powder diffractometry. The dissolution rate of SKLB610 was greatly improved in nanosuspensions, compared to crude SKLB610. Pharmacokinetic studies in rats demonstrated that the oral bioavailability of SKLB610 in nanosuspension (89.4%) was 2.6-fold higher than in coarse suspension (34.1%). Stabilizer type, milling time, and milling speed had a significant effect on particle size of the SKLB610 nanosuspensions. Nanosuspensions effectively improved the dissolution rate and bioavailability of the water-insoluble drug SKLB610 by reducing the compound particle size to the nanoscale and employing a proper formulation.

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Section: In Vitro Dissolution Testmentioning

confidence: 99%

The Preparation and Evaluation of Water-Soluble SKLB610 Nanosuspensions with Improved Bioavailability

et al. 2013

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“…The formation of the ultra-fine particles was attributed to the intensified micromixing of reactants in the rotating bed, which enhances nucleation while suppressing crystal growth. This technique was applied for nanoization of the drug cephadrine (Zhong et al 2005). Also see Bagchi et al (1997).…”

Section: Reactive Precipitationmentioning

confidence: 99%

Nanosuspensions: Emerging Novel Agrochemical Formulations

Sasson

Levy-Ruso

Toledano

et al. 2007

Insecticides Design Using Advanced Technologies

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“…In this method, it requires two solvents that are miscible. 11 Ideally, drug must dissolve in solvent, but not in anti solvent. Precipitation occurs instantaneously by rapid desolvation of drug.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Solid State Characterization and Enhancement of Dissolution Rate of Olmesartan Medoxomil by Polyvinyl Alcohol-Polyethylene Glycol Graft Copolymer Based Nanoparticles

chavan¹,

Shete²,

Janugade³

et al. 2016

IJPER

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The objectives of present investigation were to prepare and evaluate nanoparticles of Olmesartan medoxomil (OLM) by a precipitation method using polyvinyl alcoholpolyethylene glycol graft copolymer (Kollicoat IR) and to investigate the effect of stirring speed & time on particle size. Particles were characterized for drug content, FTIR, zeta potential (ZP), particle size distribution (Dynamic light scattering), differential scanning calorimeter (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), solubility, in vitro release and stability studies. All batches showed drug content in range of 93.24 ± 0.96% to 99.91 ± 0.98%, particle size in range of 136.3-188.9 nm. As stirring speed increased particles of reduced size obtained and vice versa. ZP values of formulations were from -2.28 mV to -17.90 mV & comply with requirement of ZP for stability. Solubility results indicated improvement in solubility of formulations. PXRD analysis showed particles were in same crystalline state as raw OLM. Particle exhibited enhanced dissolution compared to raw material due to reduction in particle size, increased surface area & solubility. When formulated in tablets showed improvement in dissolution, compared to marketed formulation, anti solvent precipitation method is promising tool to prepare OLM particles by using Kollicoat IR as a polymer, for enhancement of solubility, dissolution velocity of OLM.

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Preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment

Cited by 78 publications

References 20 publications

The Preparation and Evaluation of Water-Soluble SKLB610 Nanosuspensions with Improved Bioavailability

The Preparation and Evaluation of Water-Soluble SKLB610 Nanosuspensions with Improved Bioavailability

Nanosuspensions: Emerging Novel Agrochemical Formulations

Formulation, Solid State Characterization and Enhancement of Dissolution Rate of Olmesartan Medoxomil by Polyvinyl Alcohol-Polyethylene Glycol Graft Copolymer Based Nanoparticles

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