Preparation and characterization of TiO2/silicate hierarchical coating on titanium surface for biomedical applications

Huang, Qianli; Liu, Xujie; Elkhooly, Tarek A.; Zhang, Ranran; Yang, Xing; Shen, Zhijian; Feng, Qingling

doi:10.1016/j.msec.2015.11.056

Cited by 35 publications

(13 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6,7 In addition, its multi-microporous structure can achieve long-term stable release of metal ions. 8 Chen et al reported that crystalline hydroxyapatite (HA) can be obtained directly by MAO. 9 However, high crystalline HA formed under high-temperature arc conditions is difficult to degrade and has weak biological activity and relatively single structure.…”

Section: Introductionmentioning

confidence: 99%

<p>Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits</p>

Zhao

et al. 2020

IJN

View full text Add to dashboard Cite

Enhancing osteointegration of implants in osteoporosis patients is a necessity since implantations frequently fail in these patients. The aim of this work is to study how simvastatin-strontium-hydroxyapatite coated implants perform in rabbits with osteoporosis. Materials and Methods: Crystalline HA and Sr-HA oxide film were prepared through micro-arc oxidation. Surface characterization including morphology, roughness, element composition, phase composition, hydrophilicity were then evaluated. Simvastatin loaded on porous films through immersion, and the effects of coatings on osteointegration in osteoporotic rabbits were investigated. All samples were obtained after 4, 8 and 12 weeks of healing. Some of them were subjected to biomechanical tests and others were subjected to histological and histomorphometric analysis. Results: Coatings exhibited a microporous network structure with appropriate roughness and high hydrophilicity. Compared to control HA and machined surface implants, simvastatin-Sr-HA coated implants exhibited marked improvements in osteointegration, which is characterized by a quicker mineralization deposition rate, good bone formation mode (large amount of contact osteogenesis and a small amount of distance osteogenesis) and increased bone-to-implant contact and pull-out strength. Conclusion: These biological parameters demonstrate the excellent osteoconductivity of simvastatin-Sr-HA coatings in the osteoporotic state. Overall, this suggests that simvastatin-Sr-HA coatings would be applicable in poor-quality bones of patients experiencing osteoporosis.

show abstract

Section: Introductionmentioning

confidence: 99%

<p>Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits</p>

Zhao

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…In particular, chemical treatments, such as graphene oxide, enhance the bone formation by increasing osteoblastic MC3T3-E1 cell proliferation rate; while, the surfaces coating with Poly(ε-caprolactone) and Poly(propylene fumarate) ameliorate the adhesion capability of cultured cells [19,20,21,22]. Moreover, physical treatment such as hydroxyapatite deposition or TiO 2 /silicate coating on titanium plates significantly influences the hydrophilicity, protein adsorption, and in vitro bioactivity of biomaterials [23,24]. Some authors suggested that sand-blasting treatment is an effective method to greatly improve the surface bio-performances of implant biomaterials [25].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility Analyses of Al2O3-Treated Titanium Plates Tested with Osteocyte and Fibroblast Cell Lines

et al. 2017

View full text Add to dashboard Cite

Osseointegration of a titanium implant is still an issue in dental/orthopedic implants durable over time. The good integration of these implants is mainly due to their surface and topography. We obtained an innovative titanium surface by shooting different-in-size particles of Al2O3 against the titanium scaffolds which seems to be ideal for bone integration. To corroborate that, we used two different cell lines: MLO-Y4 (murine osteocytes) and 293 (human fibroblasts) and tested the titanium scaffolds untreated and treated (i.e., Al2O3 shot-peened titanium surfaces). Distribution, density, and expression of adhesion molecules (fibronectin and vitronectin) were evaluated under scanning electron microscope (SEM) and confocal microscope (CM). DAPI and fluorochrome-conjugated antibodies were used to highlight nuclei, fibronectin, and vitronectin, under CM; cell distribution was analyzed after gold-palladium sputtering of samples by SEM. The engineered biomaterial surfaces showed under SEM irregular morphology displaying variously-shaped spicules. Both SEM and CM observations showed better outcome in terms of cell adhesion and distribution in treated titanium surfaces with respect to the untreated ones. The results obtained clearly showed that this kind of surface-treated titanium, used to manufacture devices for dental implantology: (i) is very suitable for cell colonization, essential prerequisite for the best osseointegration, and (ii) represents an excellent solution for the development of further engineered implants with the target to obtain recovery of stable dental function over time.

show abstract

“…Moreover, except for the first several days, a long-term stable release of metallic ions from the oxide deposition layers can be achieved by using the microporous structures formed during the MAO process 8) . In this study, Ti surfaces were modified by MAO using electrolytes with different Sr concentrations to promote calcification of preosteoblasts.…”

Section: Introductionmentioning

confidence: 99%

“…However, their poor bone fusion properties limit their clinical applications 1) . Various techniques have been explored to modify the surfaces of Ti and its alloys to improve their osseointegration, including plasma spraying, sol-gel method, and electrochemical deposition [2][3][4][5][6][7][8][9][10][11][12] . Among these modification methods, micro-arc oxidation (MAO) has attracted special attention since it is a relatively convenient and effective technique for depositing oxide coatings on the surfaces of nonferrous metals [9][10][11][12] .…”

mentioning

confidence: 99%

Effect of strontium ions on calcification of preosteoblasts cultured on porous calcium- and phosphate-containing titanium oxide layers formed by micro-arc oxidation

et al. 2016

View full text Add to dashboard Cite

INTRODUCTIONTitanium (Ti) and its alloys have been used in dentistry as implant materials because of their good mechanical properties, high corrosion resistance, and low cytotoxicity. However, their poor bone fusion properties limit their clinical applications 1) . Various techniques have been explored to modify the surfaces of Ti and its alloys to improve their osseointegration, including plasma spraying, sol-gel method, and electrochemical deposition [2][3][4][5][6][7][8][9][10][11][12] . Among these modification methods, micro-arc oxidation (MAO) has attracted special attention since it is a relatively convenient and effective technique for depositing oxide coatings on the surfaces of nonferrous metals [9][10][11][12] . More importantly, by using this technique, various desired elements can be introduced into the coated layers with porous structures 11) , such as calcium (Ca), phosphorus (P), magnesium (Mg) and strontium (Sr), which are trace elements in the human body playing a significant role in bone formation.Sr is considered a bioactive element that improves implant osseointegration. As was previously reported, Sr ions have been shown to enhance bone collagen synthesis and decrease bone resorption by inhibiting osteoclast resorbing activity [13][14][15][16][17][18][19][20] . Therefore, it is expected that a local release of Sr ions from implant surfaces would directly improve implant osseointegration.Since our previous studies have shown that MAO is a promising method to produce porous and firmly adherent bone formation concerned elements contained oxide deposition layers on metal substrates 11) , it is easy to optimize the Sr amounts introduced into the oxide deposition layers by altering MAO electrolyte compositions. Moreover, except for the first several days, a long-term stable release of metallic ions from the oxide deposition layers can be achieved by using the microporous structures formed during the MAO process 8) . In this study, Ti surfaces were modified by MAO using electrolytes with different Sr concentrations to promote calcification of preosteoblasts. Morphologies and elemental compositions of the surfaces as well as cross-sections of the Ti specimens obtained with and without MAO were characterized by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). A mouse preosteoblast MC3T3-E1 was utilized to study the calcification effect of Sr contents in the MAO-deposited layers on the Ti substrates in vitro. Osteogenic differentiation and calcified depositions of the MC3T3-E1 cells cultured on all specimens were evaluated using alkaline phosphatase (ALP) activity assay and alizarin red s staining, respectively. MATERIALS AND METHODS Ti substrate preparationCommercially pure Ti discs (grade 2, 8 mmφ×2.0 mm in thickness, Rare Metallic, Tokyo, Japan) were used in this study. Before the MAO treatment, Ti discs were mechanically polished with up to #800-grid SiC abrasive paper and then ultrasonically rinsed in acetone and ethanol. The obtained specimens (not subjected to...

show abstract

Preparation and characterization of TiO2/silicate hierarchical coating on titanium surface for biomedical applications

Cited by 35 publications

References 48 publications

<p>Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits</p>

<p>Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits</p>

Biocompatibility Analyses of Al2O3-Treated Titanium Plates Tested with Osteocyte and Fibroblast Cell Lines

Effect of strontium ions on calcification of preosteoblasts cultured on porous calcium- and phosphate-containing titanium oxide layers formed by micro-arc oxidation

Contact Info

Product

Resources

About