Preparation and Characterization of Surface-Modified Silica-Nanoparticles

Abstract

Stöber silica particles having diameters of ca. 100 and ca. 200 nm were prepared and silylated using trimethylsilyl N,N-dimethylcarbamate, achieving a range of surface coverage by trimethylsilyl groups by varying the amounts of silylating agent used. The efficacy of silylation was characterized in terms of hydrophobicity of the particles which was assessed by film balance investigations at water−air interfaces and additionally by imaging the long- and short-range structures of silica particulate layers at water−air interfaces and on mica supports by using Brewster-angle and atomic force microscopies.

Core‐Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra‐large Cavity for Protein Delivery

“…The z -average diameter of MSN-CC in deionized (DI) water is 220 nm ( Figure S1 and Table S1, Supporting Information). This DLS measurement represents the hydrodynamic diameter of the particle including surrounding water molecules, [ 21 ] thus the value is slightly larger than the size determined by TEM. The low polydispersity index (PDI) of 0.125 suggests that MSN-CC is monodispersed without signifi cant aggregation.…”

Hexagonally Close Packed Langmuir-Blodgett Films from Monodispersed Silica Nanoparticles

“…The morphology of LB film can be characterized using optical spectroscopy, transmission electron microscopy, scanning electron microscopy, atomic force microscopy, scanning tunneling microscopy, or ellipsometry. [13][14][15] The Stöber method, employed to produce silica particles, has been used for several decades owing to simplicity and ease to control the particle size. 16 This synthetic procedure allows the production of silica particles in a wide range of sizes, nearly spherical in shape and a narrow size distribution.…”

Experimental Considerations on The Cytotoxicity of Nanoparticles

“…Choosing the appropriate cytotoxicity assay method is also an important consideration, since some may interfere with the actual toxic effect produced by the nanoparticle [26–29]. The alteration of nanoparticle properties is also a notable issue since nonspecific protein adsorption and aggregation of particles can change the surface charge, surface composition and the size compared with the initially prepared particle when placed in the biological media [30–36]. In order to perform more reliable experiments and obtain undistorted results, a thorough understanding and ability to track the transport of the nanoparticle in a biological system is essential.…”