Preparation and characterization of surface molecularly imprinted films coated on multiwall carbon nanotubes for recognition and separation of lysozyme with high binding capacity and selectivity

Xu, Xinya; Guo, Pengqi; Luo, Zhimin; Ge, Yanhui; Zhou, Yulan; Chang, Ruimiao; Du, Wei; Chang, Chun; Fu, Qiang

doi:10.1039/c6ra28063c

Cited by 28 publications

(10 citation statements)

References 44 publications

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“…For sensor applications, the composite fluorescence probes using QDs incorporated into MIPs have been developed as highly selective fluorescence probes for the determination of some target compounds such as salbutamol [28], patulin [29], sulfadiazine [30], sulfadimidine [31], malachite green [32], tetracycline [33], cocaine [34] and amoxicillin [35]. To improve the kinetic adsorption or affinity binding of ciprofloxacin, addition of carboxylic acid functionalized multiwall carbon nanotubes is an interesting alternative approach since they contain an extended  structure which can adsorb aromatic compounds via - interactions [36]. The carboxylic acid functionalisation of multiwall carbon nanotubes can improve their dispersibility in aqueous media and it is easy to achieve further covalent functionalisation with other materials [37].…”

Section: Introductionmentioning

confidence: 99%

A nanocomposite optosensor containing carboxylic functionalized multiwall carbon nanotubes and quantum dots incorporated into a molecularly imprinted polymer for highly selective and sensitive detection of ciprofloxacin

Yuphintharakun

Nurerk

Chullasat

et al. 2018

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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A nanocomposite optosensor consisting of carboxylic acid functionalized multiwall carbon nanotubes and CdTe quantum dots embedded inside a molecularly imprinted polymer (COOH@MWCNT-MIP-QDs) was developed for trace ciprofloxacin detection. The COOH@MWCNT-MIP-QDs were synthesized through a facile sol-gel process using ciprofloxacin as a template molecule, 3-aminopropylethoxysilane as a functional monomer and tetraethoxysilane as a cross-linker at a molar ratio of 1:8:20. The synthesized nanocomposite optosensor had high sensitivity, excellent specificity and high binding affinity to ciprofloxacin. Under optimal conditions, the fluorescence intensity of the optosensor decreased in a linear fashion with the concentration of ciprofloxacin and two linear dynamic ranges were obtained, 0.10-1.0 μg L and 1.0-100.0 μg L with a very low limit of detection of 0.066 μg L. The imprinting factors of the two linear range were 17.67 and 4.28, respectively. The developed nanocomposite fluorescence probe was applied towards the determination of ciprofloxacin levels in chicken muscle and milk samples with satisfactory recoveries being obtained in the range of 82.6 to 98.4%. The results were also in good agreement with a HPLC method which indicates that the optosensor can be used as a sensitive, selective and rapid method to detect ciprofloxacin in chicken and milk samples.

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Section: Introductionmentioning

confidence: 99%

A nanocomposite optosensor containing carboxylic functionalized multiwall carbon nanotubes and quantum dots incorporated into a molecularly imprinted polymer for highly selective and sensitive detection of ciprofloxacin

Yuphintharakun

Nurerk

Chullasat

et al. 2018

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…The combination of MMIPs with nanomaterials ( e.g. , GO, 73 CNTs 74 ), nucleic acid aptamer, 60 metal ion coordination 56 and other materials has been validated in the selective extraction of biomarkers.…”

Section: Selective Adsorption Of Biomarkers By Mmipsmentioning

confidence: 99%

Application progress of magnetic molecularly imprinted polymers chemical sensors in the detection of biomarkers

Wang

Yang

Pang

et al. 2022

Analyst

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“…Emerging techniques for lysozyme measurement in biological samples include antibody [31][32][33], aptamer [34], MIP [35] or nanoparticle-based [36] biosensors and the use of core-shell polymer NPs as selective extraction sorbents in the sample cleanup process. Most of the newly developed lysozyme nanoadsorbents use a molecular imprinting strategy [37][38][39][40][41][42][43][44][45][46] and only one of them relies on a polymeric material [18] with optimized composition of special functional monomers to achieve selectivity. The majority of the works focus on the preparation and characterization of the adsorbent particles but, unfortunately, the demonstration of their practical applicability through validated method development has received very little attention up to now.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Responsive Magnetic Nanoparticles for Bioanalysis of Lysozyme in Urine Samples

2021

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Highly selective multifunctional magnetic nanoparticles containing a thermoresponsive polymer shell were developed and used in the sample pretreatment of urine for the assessment of lysozymuria in leukemia patients. Crosslinked poly(N-isopropylacrylamide-co-acrylic acid-co-N-tert-butylacrylamide) was grown onto silica-coated magnetic nanoparticles by reversible addition fragmentation chain transfer (RAFT) polymerization. The lysozyme binding property of the nanoparticles was investigated as a function of time, protein concentration, pH, ionic strength and temperature and their selectivity was assessed against other proteins. High-abundant proteins, like human serum albumin and γ-globulins did not interfere with the binding of lysozyme even at elevated concentrations characteristic of proteinuria. A sample cleanup procedure for urine samples has been developed utilizing the thermocontrollable protein binding ability of the nanoparticles. Method validation was carried out according to current bioanalytical method validation guidelines. The method was highly selective, and the calibration was linear in the 25 to 1000 µg/mL concentration range, relevant in the diagnosis of monocytic and myelomonocytic leukemia. Intra- and inter-day precision values ranged from 2.24 to 8.20% and 1.08 to 5.04%, respectively. Intra-day accuracies were between 89.9 and 117.6%, while inter-day accuracies were in the 88.8 to 111.0% range. The average recovery was 94.1 ± 8.1%. Analysis of unknown urine samples in comparison with a well-established reference method revealed very good correlation between the results, indicating that the new nanoparticle-based method has high potential in the diagnosis of lysozymuria.

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Preparation and characterization of surface molecularly imprinted films coated on multiwall carbon nanotubes for recognition and separation of lysozyme with high binding capacity and selectivity

Cited by 28 publications

References 44 publications

A nanocomposite optosensor containing carboxylic functionalized multiwall carbon nanotubes and quantum dots incorporated into a molecularly imprinted polymer for highly selective and sensitive detection of ciprofloxacin

A nanocomposite optosensor containing carboxylic functionalized multiwall carbon nanotubes and quantum dots incorporated into a molecularly imprinted polymer for highly selective and sensitive detection of ciprofloxacin

Application progress of magnetic molecularly imprinted polymers chemical sensors in the detection of biomarkers

Temperature-Responsive Magnetic Nanoparticles for Bioanalysis of Lysozyme in Urine Samples

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