Preparation and characterization of spherical monodisperse silica dispersions in nonaqueous solvents

Helden, A.K. Van; Jansen, Joachim; Vrij, A.

doi:10.1016/0021-9797(81)90417-3

Cited by 504 publications

(339 citation statements)

References 23 publications

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“…The particle size was determined by static and dynamic light scattering in dilute dispersions [8]. The size of the particle was found by static light scattering from a plot of the logarithm of the scattered intensity vs. the square of the wave vector K (a so-called Guinier plot).…”

Section: Characterizationmentioning

confidence: 99%

Preparation of polymethylmethacrylate latices in non-polar media

Pathmamanoharan

Slob

Lekkerkerker

1989

Colloid & Polymer Sci

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Section: Characterizationmentioning

confidence: 99%

Preparation of polymethylmethacrylate latices in non-polar media

Pathmamanoharan

Slob

Lekkerkerker

1989

Colloid & Polymer Sci

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“…The first condition is typical of the well-known "Stöber method," 32 while in the second case, hydrolysis occurs in inverse micelles formed in water in oil reverse microemulsions. 33 Nonporous SiO 2 NPs produced by both of these methods are of interest for biomedical uses. Applications range from the delivery of conjugated or encapsulated small drugs, proteins, genes, or agents active in photodynamic therapy to molecular imaging by incorporation of contrast agents or photoluminescent dyes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Silica Surface Properties on the Formation of Multilayer or Submonolayer Protein Hard Corona: Albumin Adsorption on Pyrolytic and Colloidal SiO₂ Nanoparticles

et al. 2015

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The adsorption of bovine serum albumin (BSA) on two types of silica nanoparticles (NPs), one pyrolytic (P−SiO 2 ; namely AOX50 by Evonik) and the other colloidal (lab-made by using inverse micelles microemulsion, M−SiO 2 ), is studied. Both materials are characterized in terms of size of primary particles (by transmission electron microscopy), amounts (by thermogravimetry) and distribution of silanols (IR spectroscopy in controlled atmosphere, augmented by H/D isotopic exchange and reaction with VOCl 3 , to distinguish silanols actually located at the surface of nanoparticles), water contact angle, ζ−potential and dispersion state in water, PBS buffer and BSA solutions in PBS (by dynamic light scattering, DLS). Proteins are found to act as dispersing agent toward the large aggregates formed by both types of NPs in PBS buffer, although monodispersion was not attained in the conditions investigated. The problem of the determination of the silica surface actually available in NPs agglomerates for protein adsorption is addressed, and a model based on the external area of the agglomerates determined by DLS is proposed, supported by the trend of ζ−potential in dependence on the amount of adsorbed BSA and by the UV circular dichroism spectra of adsorbed proteins. The spectra reveal the occurrence of protein-protein interactions for BSA on P−SiO 2 , where multilayers of irreversibly adsorbed BSA molecules (i.e. a so called protein hard corona) are proposed to be formed. Conversely, the model indicates the formation of a sub-monolayer protein hard corona on M−SiO 2 . The difference in protein coverage appears to be related to differences in the distribution of surface silanols, more than to differences in ζ−potential.

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“…When most of the stearyl alcohol was removed the silica was dispersed in cyclohexane and after centrifugation the supernatant was discarded. For further details of the preparation of lyophilic silica dispersions we refer to a forthcoming paper (26).…”

Section: Methodsmentioning

confidence: 99%

“…Compared with the hydrodynamic radius (see next section), this is quite low. We think that this discrepancy is the result of particle shrinkage as a result of radiation (26). The size distribution is shown in Fig.…”

Section: Electron Microscopymentioning

confidence: 97%

Static light scattering of concentrated silica dispersions in apolar solvents

Helden¹,

Vrij²

1980

Journal of Colloid and Interface Science

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100

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Organophilic silica dispersions, containing spherical monodisperse particles up to concentrations of 80% (w/v) of silica, were studied with the (static) light-scattering method. Cyclohexane and chloroform were chosen as solvents in order to minimize the scattering intensity. The results were interpreted with fluid-state theories. In a large range of silica concentrations the osmotic compressibility as well as the scattering at finite angles could be described rather well with hardsphere interactions. The hard-sphere radius was rather close to the hydrodynamic radius of the particle. At the highest particle concentrations the scattering intensity sharply increases for small scattering angles. This is attributed to formation of large dense clusters of primary particles.

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Preparation and characterization of spherical monodisperse silica dispersions in nonaqueous solvents

Cited by 504 publications

References 23 publications

Preparation of polymethylmethacrylate latices in non-polar media

Preparation of polymethylmethacrylate latices in non-polar media

Effect of Silica Surface Properties on the Formation of Multilayer or Submonolayer Protein Hard Corona: Albumin Adsorption on Pyrolytic and Colloidal SiO₂ Nanoparticles

Static light scattering of concentrated silica dispersions in apolar solvents

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Preparation and characterization of spherical monodisperse silica dispersions in nonaqueous solvents

Cited by 504 publications

References 23 publications

Preparation of polymethylmethacrylate latices in non-polar media

Preparation of polymethylmethacrylate latices in non-polar media

Effect of Silica Surface Properties on the Formation of Multilayer or Submonolayer Protein Hard Corona: Albumin Adsorption on Pyrolytic and Colloidal SiO2 Nanoparticles

Static light scattering of concentrated silica dispersions in apolar solvents

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Effect of Silica Surface Properties on the Formation of Multilayer or Submonolayer Protein Hard Corona: Albumin Adsorption on Pyrolytic and Colloidal SiO₂ Nanoparticles