Preparation and Characterization of Satranidazole Loaded Calcium Pectinate Microbeads for Colon Specific Delivery; Application of Response Surface Methodology

Tiwari, Akanksha; Ramteke, Suman; Dahima, Rashmi; Shukla, Rajkumar

doi:10.2174/157341311796196871

Cited by 10 publications

(9 citation statements)

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“…The methods that have been reported for evaluation of colon targeted delivery systems include triggering by enzymes (Philip et al, 2008;Fetzner et al, 2004;Macfarlane et al, 1989;Maculotti et al, 2009;Maestrelli et al, 2008;Liu et al, 2012;Semde et al, 2000a,b Omar et al, 2007Jain et al, 2007a,b et al, 2010), rat caecal contents (Rubinstein et al, 1993;Jain et al, 2007a,b;Watanabe et al, 1998;Takemura et al, 2000;Tiwari et al, 2011;Shukla et al, 2012Shukla et al, , 2011Krishnaiah et al, 2001;Shyale et al, 2005;Ravi et al, 2008;Varshosaz et al, 2010;Singhal et al, 2011;Wei et al, 2007;Seal and Mathers, 2001), human faecal slurries (Salunkhe and Kulkarni, 2008;Siew et al, 2000Siew et al, , 2004McConnel et al, 2007;Karrout et al, 2009;Krenzlin et al, 2011), and multi stage compound culture system (Yang, 2008;Kotla et al, 2014;Schacht et al, 1996). Despite a large number of research reports on microbially triggered delivery systems for colon delivery, no such product is commercially available.…”

Section: Introductionmentioning

confidence: 99%

A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice

Singh

Yadav

Prudhviraj

et al. 2015

European Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice

Singh

Yadav

Prudhviraj

et al. 2015

European Journal of Pharmaceutical Sciences

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“…12,13 At present CaP is usually prepared by combining calcium chloride with pectin. [7][8][9][10]13,14 This type of CaP is designed as C-CaP in the present study. The preparation conditions, functional groups, rheology, and morphology of C-CaP have been studied extensively.…”

Section: ■ Introductionmentioning

confidence: 99%

Characteristics of Two Calcium Pectinates Prepared from Citrus Pectin Using Either Calcium Chloride or Calcium Hydroxide

Duan

Wang

et al. 2014

J. Agric. Food Chem.

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Calcium pectinate (CaP) was prepared from citrus pectin using either calcium chloride (C-CaP) or calcium hydroxide (HO-CaP) as the source of calcium for the reaction. The production yields and the rates of decalcification for the two calcium pectinates were compared and both found to be lower for C-CaP than for HO-CaP. In an attempt to explain these differences, certain chemical and structural characteristics of the two products, including functional groups (-CH3, C═O, COO-), rheological properties, morphology, and egg-box junction zones, were investigated by Fourier transformation infrared (FTIR) spectroscopy, rheology, scanning electron microscopy (SEM), and X-ray diffraction (XRD). The results from FTIR showed that, with an increase in calcium content, the wavenumber values and peak areas of FTIR for -CH3, C═O, and COO- groups all changed dramatically for C-CaP, while they were virtually unchanged for HO-CaP. Rheological analysis of the CaP gel showed that C-CaP had a stronger cross-linked network structure and a greater range of elastic behavior as compared to HO-CaP. SEM images of two CaP gels showed irregular membranes. C-CaP maintained a tight structure and a smooth surface, whereas HO-CaP was loose and rough. The results from XRD revealed a higher degree of crystallinity within C-CaP than within HO-CaP, which indicated that C-CaP possessed compact, ordered, and stable egg-box junction zones while the junction zones in HO-CaP were metastable and loose.

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“…The medium was prepared by the method reported by Tiwari et al,7 Krishnaiah et al,12 and Van and Kinget 13. The cecum bag was opened and its contents were weighed and homogenized, then suspended in phosphate buffer (pH 6.8) to give the desired concentrations (0, 2, and 4%) of cecal contents.…”

Section: Methodsmentioning

confidence: 99%

“…Multiparticulate systems have several advantages over conventional single‐unit systems such as more predictable rate of gastric emptying, site specificity, and fewer local adverse effects. The pH‐sensitive polymers are not suitable for colon‐targeted drug delivery systems because of the poor site specificity 7, 8…”

Section: Introductionmentioning

confidence: 99%

Design and development of microparticulate delivery system of metronidazole: Experimental design methodology

Shukla¹,

Tiwari²

2012

J of Applied Polymer Sci

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This study describes the application of response surface methodology in the optimization of guar gum microspheres for colon‐specific delivery of metronidazole. The effect of varying the relative percent of the four factors used, that is guar gum, glutaraldehyde, swelling time, and stirring speed, has been systematically investigated for identifying their best values to optimize the drug release and encapsulation efficiency as well as to highlight possible interactions among the components. Different batches were prepared according to 24 factorial designs and randomly evaluated for drug release and drug encapsulation efficiency. Analysis of response surface plots allowed identification of the best combination of four levels to minimize drug release in upper part of gastrointestinal tract and maximize the encapsulation efficiency. The scanning electron microscopy was used to characterize the surface of these microspheres. Drug polymer interactions were assessed by differential scanning calorimetry and XRD. The good correspondence between calculated and experimental values indicated in the validity of the generated statistical model. Only a small fraction of drug was released at acidic pH; however, the release of drug was found to be higher in the presence of rat cecal contents, indicating the susceptibility of crosslinked guar gum matrix to colonic enzymes released from rat cecal contents. Metronidazole release kinetics corresponds best to zero‐order model and drug release mechanism was diffusion and swelling controlled. The significance of differences was evaluated by analysis of variance (ANOVA). Differences were considered statistically significant at P < 0.05. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

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Preparation and Characterization of Satranidazole Loaded Calcium Pectinate Microbeads for Colon Specific Delivery; Application of Response Surface Methodology

Cited by 10 publications

References 0 publications

A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice

A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice

Characteristics of Two Calcium Pectinates Prepared from Citrus Pectin Using Either Calcium Chloride or Calcium Hydroxide

Design and development of microparticulate delivery system of metronidazole: Experimental design methodology

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