Preparation and characterization of porous scaffold composite films by blending chitosan and gelatin solutions for skin tissue engineering

Rahman, Mohammed Mizanur; Pervez, Shahed; Nesa, Bodrun; Khan, Mubarak A.

doi:10.1002/pi.4299

Cited by 50 publications

(33 citation statements)

References 26 publications

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“…A representative SEM micrograph for the composite film CGT1-1 is shown in Figure 3. Analysis of micrograph revealed homogeneous nature of the composite film which is in accordance with the literature report 28 and uniform dispersion of the loaded drug throughout the entire film without any agglomeration. Dispersed drug (Theophylline) crystals were clearly seen at higher magnifications ( Figure 3 (d)).…”

Section: Characterization Of Polymer Filmssupporting

confidence: 73%

Untitled

2014

IJPSR

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Natural polymer composite films from a mixture of chitosan and gelatin of various compositions were solution casted using acetic acid with and without theophylline. The films were characterized by FT-IR, TG, differential scanning calorimetry, SEM, XRD and swellability in phosphate buffer. SEM micrographs indicated uniform dispersion of the drug in the polymer blend and drug crystals were seen at higher magnification. TG, DSC and FT-IR studies implied polymerpolymer and polymer-drug weak interactions in the casted film. In vitro transdermal delivery of drug from theophylline loaded films were evaluated spectrophotometrically in phosphate buffer (pH=5.4) using Franz diffusion cell. The study revealed that at initial stage of release (upto 6h) there was only moderate change on the drug release profiles with increased content of gelatin in the film. But at higher release times (10h) the release rate was enhanced with increased gelatin-chitosan ratio. This was attributed to the improved swellability of the film in the buffer. The drug release followed a non-Fickian mechanism. The experimental observations implied that the gelatin-chitosan composite film may be used as transdermal carrier for systemic delivery of drug via the skin.

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Section: Characterization Of Polymer Filmssupporting

confidence: 73%

Untitled

2014

IJPSR

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“…The first endothermic phase transition of non-irradiated gelatin took place at 101 °C that was assigned as the denaturation of gelatin. The denaturation temperatures of γ-irradiated gelatin were found from 91 °C (for 0.2 kGy dose) which then increases as the radiation doses are increased and the detection of this transition is not easy with a hydrophilic material as water is also lost in the same temperature range (Rahman et al 2013). The second endothermic phase transition of non-irradiated gelatin took place near 155 °C that was assigned to the glass transition followed by a slight indication for exothermic crystallization at 201 °C.…”

Section: Resultsmentioning

confidence: 99%

“…Because of the favorable properties, such as high water solubility, non-toxicity, thermo-reversible sol–gel transition, high mechanical strength and elasticity in a dry state, moisturizing cause by binding a plenty of water molecules and admixture of small particles in water, gelatin are widely used in foods, water-soluble capsules, coating materials for oral drugs, stabilizer of photo-sensitive reagents in photographic films, adsorbent for diluted chemicals and adhesive agents (Bessho et al 2005). Furthermore, through many functional side groups of amino acids, gelatin readily undergoes chemical crosslinking, that made it suitable for its application as a biomaterial, and these advantages made gelatin-based controlled release systems in diverse fields ranging from tissue engineering to drug delivery and gene therapy (Rahman et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Physico-chemical characteristics of gamma-irradiated gelatin

et al. 2014

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This article reports the effects of gamma irradiation (dose ranges 0.1–10 kGy from 60Co source) on the characteristics of solid gelatin and the physico-mechanical, microstructural and bioactive properties of the scaffold prepared from irradiated gelatin solution. FTIR, intrinsic viscosity, bloom strength, thermal properties, SEM, tensile properties, water uptake ability and antimicrobial activities of non-irradiated and irradiated solid gelatin and its scaffolds were investigated. The detailed experimental results for the solid gelatin demonstrated that 1 kGy γ-irradiated samples showed higher intrinsic viscosity, enhanced thermal stability and bloom strength than other irradiated samples. Furthermore, the scaffold thus prepared from irradiated and non-irradiated gelatin also revealed that 1 kGy samples showed the highest tensile strength and modulus with good water resistivity than other irradiated and non-irradiated samples. In addition to the physico-mechanical properties, 1 kGy scaffolds have also exhibited the highest resistivity towards microbial growth that can have potentiality as scaffold in biomedical sector. The enhanced functional and bioactive properties at low irradiation doses (1 kGy) may occurred due to an initial breaking of hydrogen bonds of polypeptide chains in gelatin molecules that indicated by the shift of amide A, I and II peaks to higher wave numbers in FTIR. This enhancement resulted probably due to the domination of crosslinking over degradation at 1 kGy. It was also observed that 1 kGy γ-radiation-induced crosslinking has lowered the hydrophilicity by decreasing water uptake and mean pore diameter of the interconnected porous structures of gelatin.

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“…Where and are the weights of the samples, respectively, after and before soaking in water (Rahman et al, 2013).…”

Section: In Vitro Water-uptake Studiesmentioning

confidence: 99%

Formulation, in vitro evaluation and kinetic analysis of chitosan–gelatin bilayer muco-adhesive buccal patches of insulin nanoparticles

Barzoki

Emam‐Djomeh

Mortazavian

et al. 2016

Journal of Microencapsulation

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The present study was performed to optimise the formulation of a muco-adhesive buccal patch for insulin nanoparticles (NPs) delivery. Insulin NPs were synthesised by an ionic gelation technique using N-di methyl ethyl chitosan cysteine (DMEC-Cys) as permeation enhancer biopolymer, tripolyphosphate (TPP) and insulin. Buccal patches were developed by solvent-casting technique using chitosan and gelatine as muco-adhesive polymers. Optimised patches were embedded with 3 mg of insulin-loaded NPs with a homogeneous distribution of NPs in the muco-adhesive matrix, which displayed adequate physico-mechanical properties. The drug release characteristics, release mechanism and kinetics were investigated. Data fitting to Peppas equation with a correlation coefficient indicated that the mechanism of drug release followed an anomalous transport that means drug release was afforded through drug diffusion along with polymer erosion. In vitro drug release, release kinetics, physical and mechanical studies for all patch formulations reflected the ideal characteristics of this buccal patch for the delivery of insulin NPs.

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Preparation and characterization of porous scaffold composite films by blending chitosan and gelatin solutions for skin tissue engineering

Cited by 50 publications

References 26 publications

Untitled

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Physico-chemical characteristics of gamma-irradiated gelatin

Formulation, in vitro evaluation and kinetic analysis of chitosan–gelatin bilayer muco-adhesive buccal patches of insulin nanoparticles

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