Preparation and Characterization of Polycaprolactone Nanofibers for the Controlled Release of Chlorogenic Acid

Abstract

Electrospun nanofibers have gathered more consideration in worldwide to deliver the bioactive agents in a sustained manner for biomedical applications. In this study, chlorogenic acid loaded polycaprolactone nanofibers were fabricated by electrospinning process and the average fiber diameters were analyzed using scanning electron microscopy analysis. Further, Fourier transform infrared spectroscopy results confirmed that the encapsulated chlorogenic acid was not modified chemically during the electrospinning process. In addition, sustained chlorogenic acid release profile was observed for 12 days. These results imply chlorogenic acid loaded polycaprolactone nanofibers have capability to deliver the chlorogenic acid in a sustained manner for various biomedical applications.