Preparation and characterization of poly ( N -isopropylacrylamide- co -dimethylaminoethyl methacrylate) microgel latexes

Zha, Liusheng; Hu, Jun; Wang, C.; Fu, Shoukuan; Elaı̈ssari, Abdelhamid; Zhang, Y.

doi:10.1007/s003960200000

Cited by 73 publications

(62 citation statements)

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“…Recently, polymer microgels are attracting much attention for their use as drug carriers, since they exhibit high water-retaining ability, biocompatibility, biodegradability, and stimuli-sensitivity (Oh et al, 2008). The stimuli-sensitivity of microgels can be obtained by introducing specific functional groups to the polymer network or using polymers which are sensitive to stimuli such as the changes in temperature, pH, or light intensity (Liu et al, 2008;Zha et al, 2002;Zhang et al, 2006;Garcia et al, 2007). Polysaccharides (e.g.…”

Section: Introductionmentioning

confidence: 99%

Novel pH-sensitive microgels prepared using salt bridge

Xia

Kim

2010

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Novel pH-sensitive microgels prepared using salt bridge

Xia

Kim

2010

International Journal of Pharmaceutics

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“…Though burst release patterns are useful for certain 65 treatments, they are most often detrimental to the pharmacologi- 66 cal and economical performance of the drug delivery system [3]. 67 Chemical engineers have thus far addressed problems of drug 68 delivery control in hydrogel-based drug delivery systems by 69 designing nanodomain-structured materials, such as block copoly-70 mers, that bind to drug molecules through electrostatic [4,5] and 71 covalent bonds [6,7] as well as hydrophobic interactions [8,9], 72 delaying diffusion of the drug out of the material. More complex 73 assemblies combining electrostatic and hydrophobic interactions 74 have been developed to co-deliver hydrophilic and hydrophobic 75 drugs [10][11][12][13] to thereby trigger drug synergy or suppress drug 76 resistance.…”

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confidence: 99%

Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery

2015

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The sustained delivery of both hydrophobic and hydrophilic drugs from hydrogels has remained a challenge requiring the design and scalable production of complex multifunctional synthetic polymers. Here, we demonstrate that mucin glycoproteins, the gel-forming constituents of native mucus, are suitable for assembly into robust hydrogels capable of facilitating the sustained release of hydrophobic and hydrophilic drugs. Covalently-crosslinked mucin hydrogels were generated via exposure of methacrylated mucin to ultraviolet light in the presence of a free radical photoinitiator. The hydrogels exhibited an elastic modulus similar to that of soft mammalian tissue and were sensitive to proteolytic degradation by pronase. Paclitaxel, a hydrophobic anti-cancer drug, and polymyxin B, a positively-charged hydrophilic antibacterial drug, were retained in the hydrogels and released linearly with time over seven days. After four weeks of drug release, the hydrogels continued to release sufficient amounts of active paclitaxel to reduce HeLa cell viability and sufficient amounts of active polymyxin B to prevent bacterial proliferation. Along with previously-established anti-inflammatory, anti-viral, and hydrocarbon-solubilizing properties of mucin, the results of this study establish mucin as a readily-available, chemically-versatile, naturally-biocompatible alternative to complex multifunctional synthetic polymers as building blocks in the design of biomaterials for sustained drug delivery.

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“…Attempting to increase the VPTT of a PNIPAAm chain proved successful through the incorporation of hydrophilic monomers; however this rendered the structure unusable for thermosensitive drug release systems, as it diminished the sharpness of their volume phase transition and extended the phase transition temperature range [ 70 ]. Good examples of such systems are hydrogels including PNIPAAm.…”

Section: Stimuli-responsive Nanogels In Drug Delivery Systemsmentioning

confidence: 99%

Smart Stimuli-Responsive Nano-sized Hosts for Drug Delivery

Hosseini

Farjadian

Makhlouf

2016

Industrial Applications for Intelligent Polymers and Coatings

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The evolution in the synthesis of smart polymers broadens new horizons for their potent application in medicine, especially in drug delivery. Many synthetic polymers that exhibit environmentally responsive behavior are potential smart carrier candidates that allow for controlled therapeutic delivery. These materials can be loaded with specifi c drugs for therapeutic applications, releasing treatment in response to a stimulus. This stimuli-responsive capability has enabled smart polymeric materials to distribute drugs in response to commonly known exogenous and/ or endogenous stimuli. Examples of these various stimuli include pH, enzyme concentration, temperature, ultrasound intensity, as well as light, magnetic fi eld, redox gradients and a multitude of other potential stimuli. This chapter provides a detailed critical discussion and an overview of the stimuli-responsive polymers which have found applications in targeted drug delivery. Furthermore, multiresponsive systems and their forthcoming development as well as challenges associated with some stimuli-responsive systems are discussed. Finally, the most recent and emerging trends along with a look toward expected future breakthroughs using these types of nanocarriers are discussed.

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Preparation and characterization of poly ( N -isopropylacrylamide- co -dimethylaminoethyl methacrylate) microgel latexes

Cited by 73 publications

References 0 publications

Novel pH-sensitive microgels prepared using salt bridge

Novel pH-sensitive microgels prepared using salt bridge

Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery

Smart Stimuli-Responsive Nano-sized Hosts for Drug Delivery

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