Preparation and Characterization of Poly(N‐Vinylpyrrolidone‐co‐Methacrylic Acid) Hydrogels

Şolpan, Dilek; Kölge, Zeynep; Torun, Murat

doi:10.1081/ma-200058631

Cited by 10 publications

(9 citation statements)

References 21 publications

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“…[9, 26] The peaks around 1450 cm −1 are due to vibrational stretching bands in the pyrrolidone ring. The peak around 1170 cm −1 can be attributed to the C-N absorption band in the PVP structure,[10] but it is also possible that this peak, coupled with the peak around 1292 cm −1 , is indicative of the stretching of C=O coupled with the bending of O-H in the methacrylic acid units. [23, 27]…”

Section: Resultsmentioning

confidence: 99%

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Molecular Structure of Physiologically‐Responsive Hydrogels Controls Diffusive Behavior

Carr

Peppas

2009

Macromolecular Bioscience

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SummaryPolymeric networks and the ensuing hydrogels of methacrylic acid and N-vinyl pyrrolidone were successfully synthesized using a UV-initiated free radical polymerization and characterized to assess their applicability as carriers for directed drug delivery. FT-IR spectroscopy revealed shifts in peak absorbances that indicated the presence of hydrogen bonding complexes between functional groups, while SEM imaging showed that the different comonomers affect the surface morphology of the microparticles. Dynamic pH swelling studies demonstrated the pH responsiveness of the carriers in gastric and intestinal conditions and revealed that systems containing higher concentrations of methacrylic acid experienced the highest degree of hydrogen bonding complexation in gastric conditions. The presence of NVP in the systems enhanced swelling. Equilibrium swelling studies revealed that the mesh size was sufficiently large to allow drug diffusion across the networks.

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Section: Resultsmentioning

confidence: 99%

“…[10–12] Applications of these copolymers have been in industrial settings for water treatment[13] and pervaporation[14] purposes, pharmaceutical settings as protein mimics,[8] and drug delivery purposes in the ocular,[15] oral and colonic[12] delivery of small molecular weight peptides.…”

Section: Introductionmentioning

confidence: 99%

Molecular Structure of Physiologically‐Responsive Hydrogels Controls Diffusive Behavior

Carr

Peppas

2009

Macromolecular Bioscience

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“…Because the gelation reached maximum extent at 3.4 kGy irradiation dose, so, the hydrogels irradiated at 3.4 kGy irradiation dose were used in this study. P(VP/MAA)1, P(VP/MAA)2, P(VP/MAA)3 have been used for three different compositions of P(VP/MAA) hydrogels which contain VP/MAA monomer mixtures at three different mole percents, which are 64/36, 78/22, 82/18, respectively 14…”

Section: Resultsmentioning

confidence: 99%

“…Charged groups attached to the polymeric network structure played an essential role in swelling and adsorption properties 15. It can be seen that the swelling behaviour of the copolymer is greatly influenced by its composition 14. The equilibrium swelling behaviour of P(VP/MAA) copolymer hydrogels were investigated as a function of pH.…”

Section: Resultsmentioning

confidence: 99%

Radiation synthesis of poly(N‐vinylpyrrolidone‐co‐methacrylic acid) hydrogels and their usability in uranyl ion adsorption

Şolpan

Torun

2009

J of Applied Polymer Sci

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In this study, N-vinylpyrrolidone(VP)/ methacrylic acid (MAA) mixtures have been prepared at three different mole percents which the methacrylic acid composition around 5, 10, and 15%. Poly(N-vinylpyrrolidone-co-methacrylicacid) P(VP/MAA) hydrogels irradiated at 3.4 kGy have been used for swelling and diffusion studies in water and uranyl ion solutions. The influence of dose, pH, relative amounts of monomers in MAA/VP monomer mixtures on the swelling properties have been investigated. P(VP/MAA) hydrogels were swollen in distilled water at pH 7.0. P(VP/MAA)1 hydrogel containing 36% (mole percent) methacrylic acid showed the maximum percent swelling in water. Adsorption isotherms were constructed for uranyl ions and P(VP/MAA) hydrogel systems. It has been found that P(VP/MAA) hydrogels have very high uptake of the uranyl ions succesfully in water containing uranyl ions.

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“…Furthermore, NVP has a neutral charge that has no effect on the pH‐responsive behavior of the hydrogel and readily forms hydrogen bond complexes with MAA . Copolymers of MAA with NVP, designated as P(MAA‐ co ‐NVP), were first proposed by Carr and Peppas to serve as an alternative pH‐responsive hydrogel systems . This system has shown great promise in the delivery of protein therapeutics, such as insulin and growth hormone…”

Section: Introductionmentioning

confidence: 99%

Development of a P((MAA‐co‐NVP)‐g‐EG) Hydrogel Platform for Oral Protein Delivery: Effects of Hydrogel Composition on Environmental Response and Protein Partitioning

Steichen

O'Connor

Peppas

2016

Macromolecular Bioscience

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Hydrogels based upon terpolymers of methacrylic acid, N-vinyl pyrrolidone, and poly(ethylene glycol) are developed and characterized for their ability to respond to changes in environmental pH and to partition protein therapeutics of varying molecular weights and isoelectric points. P((MAA-co-NVP)-g-EG) hydrogels are synthesized with PEG-based cross-linking agents of varying length and incorporation densities. The composition is confirmed using FT-IR spectroscopy and shows peak shifts indicating hydrogen bonding. Scanning electron microscopy reveals microparticles with an irregular, planar morphology. The pH-responsive behavior of the hydrogels is confirmed under equilibrium and dynamic conditions, with the hydrogel collapsed at acidic pH and swollen at neutral pH. The ability of the hydrogels to partition model protein therapeutics at varying pH and ionic strength is evaluated using three model proteins: insulin, porcine growth hormone, and ovalbumin. Finally, the microparticles are evaluated for adverse interactions with two model intestinal cell lines and show minimal cytotoxicity at concentrations below 5 mg mL .

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Preparation and Characterization of Poly(N‐Vinylpyrrolidone‐co‐Methacrylic Acid) Hydrogels

Cited by 10 publications

References 21 publications

Molecular Structure of Physiologically‐Responsive Hydrogels Controls Diffusive Behavior

Molecular Structure of Physiologically‐Responsive Hydrogels Controls Diffusive Behavior

Radiation synthesis of poly(N‐vinylpyrrolidone‐co‐methacrylic acid) hydrogels and their usability in uranyl ion adsorption

Development of a P((MAA‐co‐NVP)‐g‐EG) Hydrogel Platform for Oral Protein Delivery: Effects of Hydrogel Composition on Environmental Response and Protein Partitioning

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