Preparation and characterization of poly(l-histidine)/poly(l-glutamic acid) multilayer on silicon with nanometer-sized surface structures

Vinzenz, Xenia; Hüger, Erwin; Himmerlich, Marcel; Krischok, S.; Büsch, Sebastian; Wöllenstein, Jürgen; Hoffmann, Christian

doi:10.1016/j.jcis.2012.07.057

Cited by 7 publications

(4 citation statements)

References 68 publications

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“…The reversibility of the process was assessed flushing the two identical surfaces of the membranes with the electrolyte at pH 5.5 after each measurement at acidic or alkaline pH. The resulting potential difference (streaming potential) created between the flat membrane surface mounted in parallel were converted to zeta-potential using a modified Fairbrother–Mastin equation 41…”

Section: Methodsmentioning

confidence: 99%

“…The resulting potential difference (streaming potential) created between the flat membrane surface mounted in parallel was converted to ζ potential using a modified Fairbrother−Mastin equation. 41 Water Uptake. The water uptake ability of the free-standing membranes was measured by soaking dry films of a known weight in sodium acetate buffer (pH 5.5).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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pH Responsiveness of Multilayered Films and Membranes Made of Polysaccharides

et al. 2015

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We investigated the pH-dependent properties of multilayered films made of chitosan (CHI) and alginate (ALG) and focused on their postassembly response to different pH environments using a quartz crystal microbalance with dissipation monitoring (QCM-D), swelling studies, ζ potential measurements, and dynamic mechanical analysis (DMA). In an acidic environment, the multilayers presented lower dissipation values and, consequently, higher moduli when compared with the values obtained for the pH used during the assembly (5.5). When the multilayers were exposed to alkaline environments, the opposite behavior occurred. These results were further corroborated by the ability of this multilayered system to exhibit a reversible swelling-deswelling behavior within the pH range from 3 to 9. The changes in the physicochemical properties of the multilayer system were gradual and different from those of individual solubilized polyelectrolytes. This behavior is related to electrostatic interactions between the ionizable groups combined with hydrogen bonding and hydrophobic interactions. Beyond the pH range of 3-9, the multilayers were stabilized by genipin cross-linking. The multilayered films also became more rigid while the pH responsiveness conferred by the ionizable moieties of the polyelectrolytes was preserved. This work demonstrates the versatility and feasibility of LbL methodology to generate inherently pH stimulus-responsive nanostructured films. Surface functionalization using pH responsiveness endows several biomedical applications with abilities such as drug delivery, diagnostics, microfluidics, biosensing, and biomimetic implantable membranes.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

pH Responsiveness of Multilayered Films and Membranes Made of Polysaccharides

et al. 2015

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“…Depending on the structure assumed by the polypeptides the films will present different internal structures and mechanical properties. Among the polypeptides already used, the most common are poly ( l ‐lysine) (PLL), poly ( d ‐lysine) (PDL), Poly ( l ‐glutamic acid) (PGA), poly (aspartic acid) (Pasp), poly‐ l ‐arginine (Parg), and elastin‐like recombinamers (ELRs) . Among all, PLL can be consider as a model protein, since lysine together with arginine are the major positively charged amino acids .…”

Section: Components Of Multilayered Systemsmentioning

confidence: 99%

Biomimetic Extracellular Environment Based on Natural Origin Polyelectrolyte Multilayers

Silva

Reis

Mano

2016

Small

105

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Surface modification of biomaterials is a well-known approach to enable an adequate biointerface between the implant and the surrounding tissue, dictating the initial acceptance or rejection of the implantable device. Since its discovery in early 1990s layer-by-layer (LbL) approaches have become a popular and attractive technique to functionalize the biomaterials surface and also engineering various types of objects such as capsules, hollow tubes, and freestanding membranes in a controllable and versatile manner. Such versatility enables the incorporation of different nanostructured building blocks, including natural biopolymers, which appear as promising biomimetic multilayered systems due to their similarity to human tissues. In this review, the potential of natural origin polymer-based multilayers is highlighted in hopes of a better understanding of the mechanisms behind its use as building blocks of LbL assembly. A deep overview on the recent progresses achieved in the design, fabrication, and applications of natural origin multilayered films is provided. Such films may lead to novel biomimetic approaches for various biomedical applications, such as tissue engineering, regenerative medicine, implantable devices, cell-based biosensors, diagnostic systems, and basic cell biology.

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“…We intend to combine the results of exine morphology and dominating functional groups on the pollen surface to translate both structural and biochemical information into a technical surface based on silicon microtechnology carrying a functional coating. Such coatings can, for example, be achieved with layer-by-layer (LbL) deposition of polyelectrolytes due to their applicability to substrates of different shapes and sizes, while the selfassembling layers are formed under mild conditions (Vinzenz 2012). In a first step, we present the evaluation of suitable biological models, i.e.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bioinspired functional surfaces for nanoparticle filtering

et al. 2014

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We present the development of a novel integrated device for airborne nanoparticle filtering with bioinspired nanoscale functionality. The underlying idea is to investigate the principle of adherent surfaces, e.g. pollen, as a biological model and transfer this functionality into a technology using functionalized microstructured surfaces. This might offer an efficient filtering method for nanoscale airborne particles without the limitations in gas permeability of conventional filters. We investigated the different pollen species for their structural and biochemical surface properties to achieve bioinspired surface functionality on silicon surfaces. The resulting conical structures have sizes from 4 to 20 μm. Depending on structure sizes, the adhesive properties of the surfaces towards aerosol particles could be directly influenced. The surfaces were tested in a demonstrator setup and the collection efficiency visually determined

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Preparation and characterization of poly(l-histidine)/poly(l-glutamic acid) multilayer on silicon with nanometer-sized surface structures

Cited by 7 publications

References 68 publications

pH Responsiveness of Multilayered Films and Membranes Made of Polysaccharides

pH Responsiveness of Multilayered Films and Membranes Made of Polysaccharides

Biomimetic Extracellular Environment Based on Natural Origin Polyelectrolyte Multilayers

Evaluation of bioinspired functional surfaces for nanoparticle filtering

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