Preparation and Characterization of Poly(ethylene-co-vinyl alcohol)/poly(ε-caprolactone) Blend for Bioscaffolding Applications

Abstract

In order to improve the cell adhesion on poly(ε-caprolactone) (PCL) scaffolds, poly(ethylene-co-vinyl alcohol) (E-VAL) which has hydroxyl groups capable of developing hydrogen bonds with celling was blended with this polymer. To reach this goal, a series of E-VAL/PCL blends with different compositions were prepared by the solvent casting method. The miscibility of the polymer blend was proved by differential scanning calorimetry and Fourier-transform infrared spectroscopy spectrometry. Furthermore, the mechanical properties of the polymer blends were assessed in their wet state by dynamic mechanical analysis. The surfaces wettability of blends and their components were examined through static contact angle measurements. The pore interconnections in the resulted scaffolds were achieved by the incorporation of naphthalene microparticles which were used as porogen and then removed in its gas state by sublimation under reduced pressure. The presence of pores interconnected inside the polymeric materials and their surface morphologies was examined by scanning electron microscopy. The in-vitro cytotoxicity and cell adhesion on the prepared materials were examined by an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

Poly(δ-valerolactone)/Poly(ethylene-co-vinylalcohol)/β-Tricalcium Phosphate Composite as Scaffolds: Preparation, Properties, and In Vitro Amoxicillin Release

“…When the content of PEVAL in the blend was more than 50% by weight, the decrease in the adhesion performance was due to the reduction in the size of the pores on the surface of the resulting material caused by the excessive attraction forces created by increasing the density of the hydroxyls of the polymeric blend. Similar results were also obtained by Alghamdi et al [ 70 ] in an investigation that involved PEVAL and PCL.…”

Thermal Properties, Isothermal Decomposition by Direct Analysis in Real-Time-of-Flight Mass Spectrometry and Non Isothermal Crystallization Kinetics of Poly(Ethylene-co-Vinyl Alcohol)/Poly(ε-Caprolactone) Blend

“…The miscibility of the E-VAL/PCL mixture with different compositions was recently proven by DSC and confirmed by Fourier-transform infrared (FTIR) analysis in our previous study [33]. The DSC analysis revealed the presence of a single T g in the thermograms of the blends and its negative deviation from that of the ideal, and these indicated the interaction between the chains of different natures.…”

Innovative Approaches and Advances for Hair Follicle Regeneration

“…47 EVAL is a copolymer in which the presence of hydroxyl groups promotes cell adhesion due to the hydrophilic character of the cells. 48 Alghamdi et al found that the poly(ε-caprolactone) matrix incorporated with EVAL presents a typical stress−strain pattern that is specific to a highly porous scaffold. 48 In available tests, the PEGDA hydrogels are generally non-toxic to DP aggregates, and increasing the stiffness of the gel has no significant effect on their cell viability.…”

“…48 Alghamdi et al found that the poly(ε-caprolactone) matrix incorporated with EVAL presents a typical stress−strain pattern that is specific to a highly porous scaffold. 48 In available tests, the PEGDA hydrogels are generally non-toxic to DP aggregates, and increasing the stiffness of the gel has no significant effect on their cell viability. It can be modified that changing the concentration of PEGDA can alter the mechanical stiffness of the microgel.…”