Metal Complexes of Biologically Important Ligands, LX. — Metal Complexes of 3′‐Azido‐3′‐deoxythymidine (AZT) and 3′‐Isocyano‐3′‐deoxythymidine
Metal complexes of N‐3‐deprotonated 3′‐azido‐3′‐deoxythymidine (AZT — H+), (AZT — H+)AuPR3 (R = Me, Et, Ph) (2, 3, 4), trans‐(AZT — H+)2Pd(NH3)2 (5), [(n‐Bu3P)(AZT — H+) M(μ‐Cl)2M(AZT — H+)(n‐Bu3P)] (M = Pd, Pt) (6, 7), trans‐(Ph3P)2Pd(AZT — H+)2 (8), cis‐(Ph3P)2Pt(AZT— H+)(Cl) (9), and complexes of 3′‐isocyano‐3′‐deoxythymidine (L), (Et3P)(L)‐ PdCl, (11),
(12), (n‐Bu3P)(L)PtCl2 (13), [(Ph3P)2(L)PtCl](BF4) (14), (η5‐C5Me5)(L)RhCl2 (15), and (η5‐C5Me5)(L)IrCl2 (16) have been prepared and characterized by IR and NMR spectra, 2 by X‐ray crystallography. 2, 4, and 9 show an anti‐HIV activity very similar to AZT; 2 exhibits antiinflammatory activity.