Preparation and characterization of novel fast disintegrating capsules (Fastcaps) for administration in the oral cavity

Ciper, Mesut; Bodmeier, Roland

doi:10.1016/j.ijpharm.2005.07.004

Cited by 40 publications

(19 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be probably because of the gentle movement of the tablet in the mouth and hence gentle mechanical stress on the tablet. This is in accordance with the results obtained by Ciper and Bodmeier in a study on the preparation of a fast disintegrating capsule for administration in the oral cavity 18 .…”

Section: Resultssupporting

confidence: 93%

Untitled

2012

IJPSR

View full text Add to dashboard Cite

Aceclofenac, a non-steroidal anti-inflammatory drug, with poor solubility and bioavailability was taken as candidate for enhancement of in vitro dissolution and in vivo bioavailability. Development of Aceclofenac orally disintegrating tablet (ODT) using lyophilization technique was adopted. The ODTs were prepared by freeze-drying an aqueous dispersion of Aceclofenac, matrix former, filler (sugar alcohol), and an anti-collapse. The tablets were evaluated compendial (uniformity of weight, uniformity of content, friability, in vitro disintegration time and in vitro dissolution), together with wetting time, in vivo disintegration time, moisture analysis and scanning electron microscopy. The compendial results showed that lyophilized ODTs disintegrated within few seconds and showed significantly faster dissolution rate of Aceclofenac in comparison with commercially available immediate release tablet Aceclofenac tablet (Bristaflam ® ). In vivo evaluation for the best chosen Aceclofenac ODT formulation (LA#10) was done for determination of the drug pharmacokinetics in comparison with the immediate release tablet Aceclofenac tablet (Bristaflam ® 100 mg). A randomized crossover design was adopted in the comparative bioavailability study done on four healthy volunteers. Statistical analysis revealed significant difference between the Bristaflam IR tablet and Aceclofenac ODT (LA#10) regarding the following pharmacokinetic parameters: C max , T max , t 1/2 , AUC (0-24) , AUC (0-∞) (p < 0.05); while insignificant difference regarding Mean residence time (MRT) (p > 0.05). The relative bioavailability of the Aceclofenac ODT (LA# 10) was 186.12% relative to the IR tablet (Bristaflam ® ) taken as reference standard.

show abstract

Section: Resultssupporting

confidence: 93%

Untitled

2012

IJPSR

View full text Add to dashboard Cite

show abstract

Section: Characterization Of Diclofenac Potassium Odtssupporting

confidence: 93%

Untitled

2013

IJPSR

View full text Add to dashboard Cite

Diclofenac Potassium, a sparingly soluble non-steroidal anti-inflammatory drug, was taken as candidate for decreasing the onset of action time and increasing its bioavailability by overcoming its first pass metabolism. Diclofenac Potassium orally disintegrating tablet (ODT) formulations were developed using lyophilization technique. The freeze dried tablet formulations were prepared by freeze-drying an aqueous solution of Diclofenac Potassium, matrix former, filler, and an anti-collapse. The tablets were evaluated from both compendial and non-compendial criteria (i.e. uniformity of weight, uniformity of content, friability, in vitro disintegration time, in vitro dissolution, wetting time, in vivo disintegration time, moisture analysis and scanning electron microscopy. The best formula results showed

show abstract

“…Either in a chemically modulated form or blended with other biopolymers, Ge has been widely used for wound and burn dressings, surgical treatments, and for the tissue engineering of bone, skin, and cartilage. [28][29][30][31] The aforementioned natural biopolymers generally need to be cross-linked to achieve the desired structural integrity, degradation time, and stiffness. A highly cross-linked network is required to achieve lower degradation rate.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic Acid/Gelatin Microgel‐Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration

Heris

Daoud

Sheibani

et al. 2015

Adv Healthcare Materials

View full text Add to dashboard Cite

The potential use of a novel scaffold biomaterial consisting of crosslinked hyaluronic acid (HA)–gelatin (Ge) composite microgels was investigated for use in treating vocal fold injury and scarring. Cell adhesion integrins and kinematics of cell motion were investigated in two- and three-dimensional culture conditions, respectively. Human vocal fold fibroblast (hVFF) cells were seeded on HA–Ge microgels attached to a HA hydrogel thin film. The results showed that hVFF cells established effective adhesion to HA–Ge microgels through the ubiquitous expression of β1 integrin in the cell membrane. The microgels were then encapsulated in a three-dimensional HA hydrogel for the study of cell migration. The cells within the HA–Ge microgel-reinforced composite hydrogel (MRCH) scaffold had an average motility speed of 0.24±0.08 μm/minute. The recorded microscopic images revealed features that are presumably associated with lobopodial and lamellipodial cell migration modes within the MRCH scaffold. Average cell speed during lobopodial migration was greater than that during lamellipodial migration. The cells moved faster in the MRCH than in the HA–Ge gel without microgels. These findings support the hypothesis that HA–Ge MRCH promote cell adhesion and migration; thereby they constitute a promising biomaterial for vocal fold repair.

show abstract

Preparation and characterization of novel fast disintegrating capsules (Fastcaps) for administration in the oral cavity

Cited by 40 publications

References 8 publications

Untitled

Untitled

Untitled

Investigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic Acid/Gelatin Microgel‐Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration

Contact Info

Product

Resources

About