Preparation and Characterization of Novel disubstituted 1, 3-Oxazepine-tetra-one from Schiff bases reaction with 3-methylfuran-2, 5-dione and 3-Phenyldihydrofuran-2, 5-dione

Ayfan, Abdalkareem Hamad; Muslim, Rasim Farraj; Noori, Noor Sabah

doi:10.5958/0974-360x.2019.00167.7

Cited by 8 publications

(3 citation statements)

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“…Scheme-3 displays general mechanism: Scheme 3. The general mechanics of the Oxazepines MA (3)(4)(5)(6) The prepared Oxazepines were confirmed by FTIR spectroscopy. The disappearance of the azomethine bond and the appearance of stretching bands of lactone carbonyl groups in the range (1724-1701) ppm.…”

Section: Resultsmentioning

confidence: 86%

“…The C13 carbon signal appeared at (160.5)ppm belonging to the carbonyl group, and the C14 carbon signal appeared at (151.78)ppm. The sign of the as in Figure -5.Oxazepines ring MA (3)(4)(5)(6) were prepared from the reaction of Schiff bases MA (1,2) with maleic anhydride or phthalic anhydride by cyclization addition reaction (2+5) profits conferring to the following mechanics to form a heptagon (22), in a reflux condition for (6-7) hours using dry dioxane as a solvent. Scheme-3 displays general mechanism: Scheme 3.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis and cytotoxicity evaluation of pyrazole compounds bearing oxazepine core against breast cancer cells

Azzawi

Hussein

2022

ijhs

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The research included the preparation of two Schiff bases MA1,2 starting from1-methyl-pyrazole-4-carbaldehyde with 4-chloroaniline or 4-amino antipyrine in equal moles in the presence of glacial acetic acid. Then xazepane rings MA (3-6) were prepared from MA1,2 with phthalic anhydride or maleic anhydride. The prepared chemical formulas were confirmed using FTIR, 1HNMR, and 13CNMR spectroscopy. The toxicity activity of the compound MA2 against breast cancer MDA and REF cells was tested at seven concentrations (400, 200, 100, 50, 25, 12.5, 6.25) ml/ µg. The study also showed the lowest inhibition rate for MDA cancer line cells at 6.25 µg/ml by (4%) and the highest inhibition rate at 400 µg/ml by 77%, and the study showed the compound with the highest toxicity in healthy cells (64%-80%).

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Section: Resultsmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Synthesis and cytotoxicity evaluation of pyrazole compounds bearing oxazepine core against breast cancer cells

Azzawi

Hussein

2022

ijhs

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“…General procedure for the synthesis of Oxazepine compounds (D1-D3)(Alfatlawi et al, 2018;Ayfan et al, 2019) …”

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Synthesis and characterization of new 1,3-Oxazepine-4,7-dione compounds from 1,2-diaminobenzene

Jebur¹,

Albdere

Al-Hussainawy³

et al. 2022

ijhs

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In this research, done synthesized a series of new 1,3-oxazepine-4,7-dione derivatives as D1-D3 compounds via using [2+5] cycloaddition reaction. Synthesized compounds that have been bis azo groups [B1-B3] from 1,2-diaminobenzene via coupling its diazonium salt with phenoxide anion of 4-alkoxybenzaldehyde which Alkoxy was as pentyl, hexyl, and Heptyl groups. These compounds B1-B3 are condensed with 4-Bromoaniline in Schiff bases reactions to give bisazoimine derivatives C1-C3. The compounds C1-C3 were produced by cycloaddition reaction to produce 1,3-oxazepine-4,7-dione derivatives D1-D3. The structures of the synthesized compounds are characterized by spectroscopic methods, such as FTIR, and 1HNMR spectra with the elemental composition analysis. The compounds D1-D3 that are synthesized play a big role in the inhibition of growth.

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Synthesis, identification, antibacterial activity and laser effect of new derivatives of bis-1,3-oxazepene-4,7-dione and 1,3-diazepine-4,7-dione

Alasadi

Jumaa

Dalaf

2022

1st Samarra International Conference for Pure and Applied Sciences (Sicps2021): Sicps2021

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Preparation and Characterization of Novel disubstituted 1, 3-Oxazepine-tetra-one from Schiff bases reaction with 3-methylfuran-2, 5-dione and 3-Phenyldihydrofuran-2, 5-dione

Cited by 8 publications

References 0 publications

Synthesis and cytotoxicity evaluation of pyrazole compounds bearing oxazepine core against breast cancer cells

Synthesis and cytotoxicity evaluation of pyrazole compounds bearing oxazepine core against breast cancer cells

Synthesis and characterization of new 1,3-Oxazepine-4,7-dione compounds from 1,2-diaminobenzene

Synthesis, identification, antibacterial activity and laser effect of new derivatives of bis-1,3-oxazepene-4,7-dione and 1,3-diazepine-4,7-dione

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