Preparation and characterization of nimesulide loaded poly (methyl methacrylate)/poly (ethylene oxide) blend microspheres: In vitro release studies

Rao, K. Madhusudhan; Mallikarjuna, B; Prasad, CV; Sudhakar, K; Rao, K. Madhu Sudhana; Subha, M. C. S.

doi:10.4103/0973-8398.120086

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…Furthermore, the stretching vibration band of S=O in the (SO 4 ) group is referenced by the peak in the spectrum of Car. at 1261 cm −1 [ 34 – 36 ]. Figure 4 b of the FTIR of sodium alginate showed significant bands of the hydroxyl, ether, and carboxylic functional groups.…”

Section: Resultsmentioning

confidence: 99%

Tosyl-carrageenan/alginate composite adsorbent for removal of Pb2+ ions from aqueous solutions

Awed,

Mohamed,

Kamal

et al. 2024

BMC Chemistry

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The current study effectively designed novel cross-linked tosyl-carrageenan/alginate (Ts-Car/Alg) beads to remove Pb2+ ions from their aqueous solutions. To confirm the structure of the produced matrix, characterization methods such as XRD, SEM, FTIR, and EDX were used. Batch experiments were employed in order to further evaluate the adsorption efficiency of Pb2+ ions. Additionally, various variables, including contact time, solution pH, adsorbent dosage, and initial concentration of Pb2+ ions were investigated using atomic absorption. The results of this study showed that the adsorption equilibrium increased as Pb2+ ions concentration increased at pH = 5.3 after a contact time of 120 min, with 0.3 g of Ts-Car/Alg that having the best adsorption capacity at 74 mg/g. The adsorption progression was further examined using the kinetic and isothermal models. With a correlation coefficient of 0.975, the Freundlich model was thought to better fit Pb2+ ions adsorption from the isotherm investigation. Also, the adsorption kinetics were investigated using a pseudo-second-order model with 1/n ratio of 0.683. This Ts-Car/Alg adsorbent is regarded as an effective candidate to be used for water treatment because the reusability process of produced beads was successfully completed twice, and the adsorbent maintained its ability to remove Pb2+ ions. The prepared Ts-Car/Alg beads are therefore excellent candidates to be used as potent Pb2+ ions adsorbents from their aqueous solutions. The Ts-Car/Alg beads' regeneration and reusability investigation for the removal of heavy metal ions was completed in at least two successful cycles.

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Section: Resultsmentioning

confidence: 99%

Tosyl-carrageenan/alginate composite adsorbent for removal of Pb2+ ions from aqueous solutions

Awed,

Mohamed,

Kamal

et al. 2024

BMC Chemistry

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Interaction of Tretinoin and Nimesulide with Amylose Matrices

et al. 2020

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Systems of amylose with nimesulide or tretinoin are prepared and characterized in order to evaluate their in vitro release behavior. X‐ray diffraction (XRD) data of the amylose systems containing drug molecules reveal patterns characteristic of the V‐type of complexed amylose. Nevertheless, they cannot be unequivocally assigned to complexed amylose since both drugs exhibit XRD reflections at similar 2‐theta angles. Raman scattering and differential scanning calorimetry thermal analysis provide evidence suggesting that tretinoin is more likely to form molecular inclusion complexes than nimesulide. The drug–amylose interaction is also assessed by means of optical microscopy, confocal laser scanning microscopy, and scanning electron microscopy. The results reveal that the drug molecules are effectively entrapped in the amylose matrix, probably inside or between the amylose helices. Acidic and enzymatic tests allow the quantification of the drug molecules released from the matrix of the amylose systems with tretinoin or nimesulide. In the simulated intestinal fluid, the drug release of the samples reached up to ≈52% for tretinoin and ≈39% for nimesulide systems. Overall, the results show that the molecular interaction of amylose, with tretinoin appears to be more promising for efficient complexation than with nimesulide.

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Development of a Berberine Loaded Multifunctional Design for the Treatment of Helicobacter pylori Induced Gastric Ulcer

Jain

Patel

Rajpoot

et al. 2019

DDL

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Background and Objective: The H. pylori infection causes chronic inflammation and significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer. Infection with H. pylori is the well-known risk factor for gastric cancer. It is highly desirable to develop a delivery system that localizes the antibiotic at the site of infection to achieve bactericidal concentration for a longer period of time. Thus, present work aimed to develop Concanavalin-A (Con-A) conjugated gastro-retentive microspheres of polymethylmethacrylate (PMMA) and polyethylene oxide (PEO) containing berberine hydrochloride (BBR) for the treatment of H. pylori infection. </P><P> Methods: Microspheres were prepared by solvent evaporation method and characterized by particles size distribution, surface morphology, % drug entrapment and in vitro drug release in the simulated gastric fluid. Optimized microspheres were conjugated with Con-A and further characterized for Con-A conjugation efficiency, in vitro drug release and ex vivo mucoadhesive properties. </P><P> Results and Conclusion: Enhanced mucoadhesion (88±1.9%) was shown by Con-A conjugated microspheres as compared with non-conjugated microspheres (14.5±3.6%). This significant difference (p<0.05) in the mucoadhesion may be due to affinity of the Con-A towards glycoproteins of mucus membrane of stomach. Attachment of lectin (Con-A) to the microspheres significantly enhanced the mucoadhesiveness as well as also controlled the berberine release for 10 h study period. The preliminary results from this study advised that Con-A conjugated PMMA and PEO microspheres could be used to incorporate some more herbal drugs and may be used for oral administration against H. pylori in the stomach.

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Preparation and characterization of nimesulide loaded poly (methyl methacrylate)/poly (ethylene oxide) blend microspheres: In vitro release studies

Cited by 3 publications

References 43 publications

Tosyl-carrageenan/alginate composite adsorbent for removal of Pb2+ ions from aqueous solutions

Tosyl-carrageenan/alginate composite adsorbent for removal of Pb2+ ions from aqueous solutions

Interaction of Tretinoin and Nimesulide with Amylose Matrices

Development of a Berberine Loaded Multifunctional Design for the Treatment of Helicobacter pylori Induced Gastric Ulcer

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