Preparation and characterization of new materials based on silk fibroin, chitosan and nanohydroxyapatite

Sionkowska, Alina; Tuwalska, Anna

doi:10.1080/1023666x.2020.1786271

Cited by 9 publications

(7 citation statements)

References 43 publications

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“…Many studies, dealing with pharmaceutical, cosmetic, and tissue engineering applications of collagen Materials 2022, 15, 463 2 of 15 materials modified by various low-and high-molecular components, have appeared recently. For special attention deserve collagen blends containing phenolic compounds [9][10][11][12][13][14][15], polysaccharides, and their analogs, including carboxymethylcellulose, hyaluronic acid (HA), and chitosan [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Probably one of the most important modifications is associated with mechanical properties' improvement.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study

et al. 2022

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The ability to form strong intermolecular interactions by linear glucosamine polysaccharides with collagen is strictly related to their nonlinear dynamic behavior and hence bio-lubricating features. Type III collagen plays a crucial role in tissue regeneration, and its presence in the articular cartilage affects its bio-technical features. In this study, the molecular dynamics methodology was applied to evaluate the effect of deacetylation degree on the chitosan affinity to type III collagen. The computational procedure employed docking and geometry optimizations of different chitosan structures characterized by randomly distributed deacetylated groups. The eight different degrees of deacetylation from 12.5% to 100% were taken into account. We found an increasing linear trend (R2 = 0.97) between deacetylation degree and the collagen–chitosan interaction energy. This can be explained by replacing weak hydrophobic contacts with more stable hydrogen bonds involving amino groups in N-deacetylated chitosan moieties. In this study, the properties of chitosan were compared with hyaluronic acid, which is a natural component of synovial fluid and cartilage. As we found, when the degree of deacetylation of chitosan was greater than 0.4, it exhibited a higher affinity for collagen than in the case of hyaluronic acid.

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Section: Introductionmentioning

confidence: 99%

Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study

et al. 2022

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“…Chitosan/silk fibroin blend has been used by several researchers for the fabrication 3D composites containing hydroxyapatite (Hap) [ 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 ]. A new material based on hydroxyapatite/chitosan-silk fibroin (Hap/CTS-SF) in the form of the composite was prepared for bone repair and replacement by a co-precipitation method by Wang et al [ 157 ].…”

Section: Composites Based On Chitosan Silk Fibroin and Inorganic Part...mentioning

confidence: 99%

“…Xiao et al [ 169 ] proposed new scaffolds with gradient pore sizes fabricated with silk fibroin, chitosan, and nano-hydroxyapatite. The series of porous nanohydroxyapatite/silk fibroin/chitosan scaffolds has also been fabricated in our research group using the freeze-drying method [ 170 ].…”

Section: Composites Based On Chitosan Silk Fibroin and Inorganic Part...mentioning

confidence: 99%

Chitosan/Silk Fibroin Materials for Biomedical Applications—A Review

2022

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This review provides a report on recent advances in the field of chitosan (CTS) and silk fibroin (SF) biopolymer blends as new biomaterials. Chitosan and silk fibroin are widely used to obtain biomaterials. However, the materials based on the blends of these two biopolymers have not been summarized in a review paper yet. As these materials can attract both academic and industrial attention, we propose this review paper to showcase the latest achievements in this area. In this review, the latest literature regarding the preparation and properties of chitosan and silk fibroin and their blends has been reviewed.

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“…It is widely used in orthopedic and dental materials because of its excellent bioactive and biocompatibility abilities [ 32 , 111 ]. Hydroxyapatite was successfully added or precipitated in silk fibroin-based matrices [ 95 , 177 , 178 , 179 , 180 ]. Titanium dioxide (TiO 2 ) is characterized by light weight and resistance toward corrosion and it is frequently used in the fabrication of bone implants [ 181 ].…”

Section: Blendingmentioning

confidence: 99%

“…To sum up, the type and amount of material, concentration of cross-linker and fabrication protocol affect the biocompatibility of material [ 207 , 209 ]. There are a lot of cross-linking agents used for chemical cross-linking [ 206 , 207 , 208 ], e.g., glutaraldehyde [ 215 ], genipin [ 59 , 179 ], dialdehyde starch [ 108 ], glyoxal [ 171 ], EDC (N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride, NHS (N-hydroxysuccinimide), EDC/NHS mixture [ 102 , 172 , 180 ]. The structural formulas of some chemical cross-linkers are placed in Figure 14 .…”

Section: Cross-linkingmentioning

confidence: 99%

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Grabska-Zielińska

Sionkowska

2021

Materials

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This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

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Preparation and characterization of new materials based on silk fibroin, chitosan and nanohydroxyapatite

Cited by 9 publications

References 43 publications

Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study

Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study

Chitosan/Silk Fibroin Materials for Biomedical Applications—A Review

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

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