Preparation and characterization of MRI-active gadolinium nanocomposite particles for neutron capture therapy

Cho, Heui Kyoung; Cho, Hyun‐Jong; Lone, Saifullah; Kim, Dae‐Duk; Yeum, Jeong Hyun; Cheong, In Woo

doi:10.1039/c1jm11608h

Cited by 46 publications

(33 citation statements)

References 33 publications

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“…29 The diffraction peaks of the annealed films are shown high intensity than the diffraction peaks of the as-deposited one owing to larger crystalline sizes. The crystalline grain size (D p ) is calculated by using Scherrer's formula below,…”

Section: Resultsmentioning

confidence: 99%

“…The interplanar spacing from these figures are found to be 3.03-3.05 Å and 2.68 Å, which are well matched with reported values of hcp (100) and fcc (200) planes. 29 The annealed films have different XRD peak positions: hcp (100) at 29.4…”

Section: Resultsmentioning

confidence: 99%

“…[21][22][23][24][25][26][27][28][29] In this case, different sensing membranes such as Si 3 25 and SiO 2 26 in EIS structures have been reported, however the Gd 2 O 3 sensing membrane has been reported a few. 26,27 According to literature survey, there is no report on bio-analyte detection of pH or urea by using cross-point memory structure.…”

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confidence: 99%

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Cross-Point Resistive Switching Memory and Urea Sensing by Using Annealed GdO_xFilm in IrO_x/GdO_x/W Structure for Biomedical Applications

Kumar

Maikap

Ginnaram

et al. 2017

J. Electrochem. Soc.

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Resistive switching characteristics and urea sensing have been investigated by using annealed GdO x film in IrO x /GdO x /W cross-point memory for the first time. The annealed GdO x film shows larger polycrystalline grains as compared to as-deposited films, which is observed by high-resolution transmission electron microscope (HRTEM) and X-ray diffraction patterns (XRD). Surface roughness of the GdO x films on W nano-dome is observed by atomic force microscope (AFM). The annealed IrO x /GdO x /W cross-point memory shows resistance ratio of 1000× times higher, multi-level operation with varying current compliance (CC) from 10-300 μA, good non-linearity factor of 8.3, good dc switching cycles of > 1000 at CC of 10 μA, long read endurance of >10 9 cycles with pulse width of 1 μs at higher read voltage of −0.5 V, and high speed operation of 100 ns. Repeatable resistive switching characteristics at low CC of 10 μA and mechanism are due to the electric field enhancement on the W nano-dome simulated by MATLAB, which controls the O 2− ions migration through polycrystalline GdO x grain boundary as well as Schottky barrier height modulation (0.59 vs. 0.39 eV). In addition, the annealed GdO x membrane in electrolyte-insulator-semiconductor (EIS) structure shows higher pH sensitivity than the as-deposited film (53.2 vs. 45.1 mV/pH) and lower drift (1.8 vs. 2.6 mV/hr) as well as lower detection of pH change (0.034). Detection of pH and urea sensing from 6 to 24 mg/dl have been measured by using cross-point memory, and the sensing mechanism is also discussed, which will be very useful for real healthcare unit in near future.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Cross-Point Resistive Switching Memory and Urea Sensing by Using Annealed GdO_xFilm in IrO_x/GdO_x/W Structure for Biomedical Applications

Kumar

Maikap

Ginnaram

et al. 2017

J. Electrochem. Soc.

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“…It can be of interest for preparation of functional materials on the basis of rare earth (RE) compounds. Because of their luminescent, magnetic, and other properties, nanosized RE-containing materials find applications in medicine and bioassay as luminescent labels for biological imaging [1][2][3], as contrast agents for magnetic resonance imaging (MRI) [2][3][4][5][6], and as agents for radiotherapy [7,8], photodynamic therapy [3,9,10], and neutron capture therapy of cancer [11,12]. Now it is of importance to create multifunctional materials on the basis of the RE compound nanoparticles which can be applied, for example, as multiplexed imaging agents.…”

Section: Introductionmentioning

confidence: 99%

LaF3 nanoparticles surface modified with tryptophan and their optical properties

Сафронихин¹,

Ehrlich²,

Лисичкин³

2014

Applied Surface Science

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“…Due to the biomimetic and biocompatible properties of the phosphorylcholine, PC, functional group, it has been incorporated into a wide variety of polymeric materials for use in applications including drug delivery, [1][2][3] imaging, [4][5][6] and for preparing surfaces that resist protein adsorption and cell adhesion. [7][8][9] Although they possess promising properties, most PC polymers are non-degradable, which limits the scope of their use especially for applications in vivo.…”

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confidence: 99%

Controlled Synthesis of Phosphorylcholine Derivatives of Poly(serine) and Poly(homoserine)

Yakovlev

Deming

2015

J. Am. Chem. Soc.

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ABSTRACT:We report methods for the synthesis of polypeptides that are fully functionalized with desirable phosphorylcholine, PC, groups. Due to inherent challenges in the direct incorporation of the PC group into α-amino acid N-carboxyanhydride (NCA) monomers, we developed a synthetic approach that combined functional NCA polymerization with efficient postpolymerization modification. While poly(L-phosphorylcholine serine) was found to be unstable upon synthesis, we successfully prepared poly(L-phosphorylcholine homoserine) with controlled chain lengths, and found these to be water soluble with disordered chain conformations.

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Preparation and characterization of MRI-active gadolinium nanocomposite particles for neutron capture therapy

Cited by 46 publications

References 33 publications

Cross-Point Resistive Switching Memory and Urea Sensing by Using Annealed GdO_xFilm in IrO_x/GdO_x/W Structure for Biomedical Applications

Cross-Point Resistive Switching Memory and Urea Sensing by Using Annealed GdO_xFilm in IrO_x/GdO_x/W Structure for Biomedical Applications

LaF3 nanoparticles surface modified with tryptophan and their optical properties

Controlled Synthesis of Phosphorylcholine Derivatives of Poly(serine) and Poly(homoserine)

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Preparation and characterization of MRI-active gadolinium nanocomposite particles for neutron capture therapy

Cited by 46 publications

References 33 publications

Cross-Point Resistive Switching Memory and Urea Sensing by Using Annealed GdOxFilm in IrOx/GdOx/W Structure for Biomedical Applications

Cross-Point Resistive Switching Memory and Urea Sensing by Using Annealed GdOxFilm in IrOx/GdOx/W Structure for Biomedical Applications

LaF3 nanoparticles surface modified with tryptophan and their optical properties

Controlled Synthesis of Phosphorylcholine Derivatives of Poly(serine) and Poly(homoserine)

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Cross-Point Resistive Switching Memory and Urea Sensing by Using Annealed GdO_xFilm in IrO_x/GdO_x/W Structure for Biomedical Applications

Cross-Point Resistive Switching Memory and Urea Sensing by Using Annealed GdO_xFilm in IrO_x/GdO_x/W Structure for Biomedical Applications