Preparation and characterization of metformin hydrochloride controlled-release tablet using fatty acid coated granules

Kang, Ji‐Houn; Chun, Myung-Hee; Cho, Mi-Seo; Kwon, Yong-Bin; Choi, Jaecheol; Kim, Dong-Wook; Park, Chun‐Woong; Park, Eun-Seok

doi:10.1080/03639045.2020.1762198

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…The extended-release matrix tablet (MT) is the most widely used formulation, which has improved therapeutic and nontoxic effects over the past three decades. The benefit of the MT dosage form compared to a conventional dosage form is the maintenance of effective plasma concentration, uniform therapeutic responses, extended action time, and reduced administration frequency [10][11][12][13]. MT is a simple, diffusion-controlled system.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Channeling Effects Applied to Extended-Release Matrix Tablets Containing Pirfenidone

Kang

Seung-dong

Han

et al. 2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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Pirfenidone (PRF) is an anti-fibrotic agent that has been approved by the Food and Drug Administration (FDA) for the treatment of mild to moderate idiopathic pulmonary fibrosis.However, the current oral administration dosing regimen of PRF is complex and requires high doses. Patients are instructed to take PRF three times daily, with each dose consisting of up to three capsules or tablets (600 mg/day or 1.8 g/day of PRF) taken with food. To improve the dosing regimen, efforts are being made to develop an extended-release tablet with a zeroorder release pattern. In this study, two types of extended-release matrix tablets were compared: non-channeled extended-release matrix tablets (NChMT) and channeled extendedrelease matrix tablets (ChMT). In vitro release tests, swelling and erosion index, rheology studies, and X-ray microcomputed tomography (XRCT), were conducted. The results indicated that ChMT maintained a zero-order release pattern with a constant release rate, while NChMT exhibited a decreased release rate in the latter half of the dissolution. ChMT exhibited accelerated swelling and erosion compared to other formulations, and this was made possible by the presence of channels within the tablet. These channels allowed for thorough wetting and swelling throughout the entire depth of the tablet. The formation of channels was confirmed through XRCT images. In conclusion, the presence of channels in ChMT tablets increased the rate of swelling and erosion, resulting in a zero-order release pattern. This development offers the potential to improve the dosage of PRF and reduce its associated side effects.

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Section: Introductionmentioning

confidence: 99%

Characterization of Channeling Effects Applied to Extended-Release Matrix Tablets Containing Pirfenidone

Kang

Seung-dong

Han

et al. 2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…In literature, most of them are centered around the poorly water-soluble drugs [ 57 , 58 , 59 ]. In contrast, the electrospun nanofibers and other kinds of products that also provide a sustained release profile of water-soluble drugs are very limited [ 60 , 61 , 62 ], which is also a key and difficult issue in the pharmaceutical field [ 63 , 64 ].…”

Section: Introductionmentioning

confidence: 99%

“…Based on the above-mentioned background, in the present work, a new kind of core–sheath CA nanofiber is fabricated for providing a sustained release of metformin hydrochloride (MET), a popular water-soluble drug model [ 63 , 64 ]. Modified tri-axial electrospinning was conducted for producing the core–sheath nanofibers, in which an additional outer solvent was exploited for a smooth and robust preparation [ 73 , 74 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

et al. 2021

Biomolecules

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The sustained release of a water-soluble drug is always a key and important issue in pharmaceutics. In this study, using cellulose acetate (CA) as a biomacromolecular matrix, core-sheath nanofibers were developed for providing a sustained release of a model drug—metformin hydrochloride (MET). The core–sheath nanofibers were fabricated using modified tri-axial electrospinning, in which a detachable homemade spinneret was explored. A process—nanostructure–performance relationship was demonstrated through a series of characterizations. The prepared nanofibers F2 could release 95% of the loaded MET through a time period of 23.4 h and had no initial burst effect. The successful sustained release performances of MET can be attributed to the following factors: (1) the reasonable application of insoluble CA as the filament-forming carrier, which determined that the drug was released through a diffusion manner; (2) the core–sheath nanostructure provided the possibility of both encapsulating the drug completely and realizing the heterogeneous distributions of MET in the nanofibers with a higher drug load core than the sheath; (3) the thickness of the sheath sections were able to be exploited for further manipulating a better drug extended release performance. The mechanisms for manipulating the drug sustained release behaviors are proposed. The present proof-of-concept protocols can pave a new way to develop many novel biomolecule-based nanostructures for extending the release of water-soluble drugs.

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“…As a result of these attempts, controlled-release technology is developed, for instance, sustained release drug delivery systems, targeted drug delivery systems, on-demand drug delivery systems, etc. Such systems include tablets, capsules, liposomes, nanoparticles, hydrogels, microneedles and other medical devices [3,4].…”

Section: Introductionmentioning

confidence: 99%

An overview of the development of composites containing Mg and Zn for drug delivery

Niazvand¹,

Cheshmi

Zand

et al. 2020

jcc

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Preparation and characterization of metformin hydrochloride controlled-release tablet using fatty acid coated granules

Cited by 7 publications

References 27 publications

Characterization of Channeling Effects Applied to Extended-Release Matrix Tablets Containing Pirfenidone

Characterization of Channeling Effects Applied to Extended-Release Matrix Tablets Containing Pirfenidone

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

An overview of the development of composites containing Mg and Zn for drug delivery

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