Preparation and characterization of lipid based nanosystems for topical delivery of quercetin

Bose, Sonali; Michniak‐Kohn, Bozena

doi:10.1016/j.ejps.2012.12.005

Cited by 126 publications

(80 citation statements)

References 60 publications

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“…That was a sign that SLNs' integrity was breaking down. Therefore, stability measurements were terminated at this point (Bose, Michniak-Kohn 2013;Dolatabadi et al, 2014). The stability of ME was monitored by visual inspection for 2 years.…”

Section: Discussionmentioning

confidence: 99%

Preparation and characterization of non-viral gene delivery systems with pEGFP-C1 Plasmid DNA

Karagöz

Kotmakçı

Çetintaş

et al. 2018

Braz. J. Pharm. Sci.

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In recent years, non-viral delivery systems for plasmid DNA have become particularly important. They can overcome the disadvantages of viral systems such as insertional mutagenesis and unpredicted immunogenicity. Some additional advantages of non-viral gene delivery systems are; good stability, low cost, targetability, delivery of a high amount of genetic materials. The aim of the study was to develop novel non-viral nanosystems suitable for gene delivery. Two formulations were developed for this purpose: water-in-oil microemulsion (ME) and solid lipid nanoparticles (SLN). The microemulsion was composed of Peceol, Tween 80, Plurol oleique, ethanol and water. The SLN was consisting of Precirol, Esterquat-1 (EQ1), Tween 80, Lecithin, ethanol and water. Characterization studies were carried out by measuring particle size, zeta potential, viscosity and pH. TEM imaging was performed on SLN formulations. Protection against DNase I degradation was examined. Cytotoxicity and transfection efficacy of selected formulations were tested on L929 mouse fibroblast cells. Particle sizes of complexes were below 100 nm and with high positive zeta potential. TEM images revealed that SLNs are spherical. The SLN:DNA complexes have low toxicity and good transfection ability. All results showed that the developed SLN formulations can be considered as suitable non-viral gene delivery systems.

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Section: Discussionmentioning

confidence: 99%

Preparation and characterization of non-viral gene delivery systems with pEGFP-C1 Plasmid DNA

Karagöz

Kotmakçı

Çetintaş

et al. 2018

Braz. J. Pharm. Sci.

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“…[138][139][140] This technology has more advantages than other nanotechnologies in bulk production, increased stability of the carriers, and is different from solid lipid nanocarriers with the use of liquid lipids such as oleic acid. In addition, nanostructured lipid carrier has different structures such as imperfect type with different lipid structures, formless type with lipid preventing crystallization, and multiple type with the lipid oil containing bioactive compounds thereby limit the expulsion of bioactive compounds, which is a major drawback in solid lipid nanoparticles.…”

Section: Nanostructured Lipid Carriersmentioning

confidence: 99%

“…This quercetin product enhances the beauty of the skin from preventing oxidative stress. 138 Similarly, nanostructured lipid carrier was constructed using phenylethyl resorcinol with a particle size of 218 nm and showed enhanced photostability and water stability, which may be applied as a whitening agent in the near future. 142,143 Resveratrol was also constructed using nanostructured lipid carrier systems in the size range of 110 nm and showed enhanced skin protection with higher antioxidant activity, than solid lipid nanoparticle-loaded resveratrol.…”

Section: Ganesan and Choimentioning

confidence: 99%

“…145 Similarly, quercetin encapsulated into a solid lipid nanoparticle system showed increased skin retention of quercetin with greater antioxidant activity. 138,253,254 Genistein-loaded nanoemulsions were incorporated into hydrogels in the size range of 250 nm and enhanced delivery of the bioactive compound to the skin for a beauty-based therapy. In addition, coencapsulation of resveratrol and curcumin with lipid core nanocapsules increased delivery of the resveratrol to the skin.…”

Section: Phytoconstituents In Nanosize Cosmeceuticals and Skin Therapymentioning

confidence: 99%

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Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

132

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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“…This study illustrated that NLCs are viable for improved topical deliveries of QU. 59 A study performed by Kakkar et al sought to improve the oral bioavailability of curcumin by incorporating it into SLNs composed of soy lecithin. The microemulsification method was used to prepare this formulation.…”

Section: Solid Lipid Nanoparticles and Nanostructured Lipid Carriersmentioning

confidence: 99%

Nanotechnology-based drug delivery systems and herbal medicines: a review

Bonifácio¹,

Silva²,

Ramos³

et al. 2013

IJN

250

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Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines.

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Preparation and characterization of lipid based nanosystems for topical delivery of quercetin

Cited by 126 publications

References 60 publications

Preparation and characterization of non-viral gene delivery systems with pEGFP-C1 Plasmid DNA

Preparation and characterization of non-viral gene delivery systems with pEGFP-C1 Plasmid DNA

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Nanotechnology-based drug delivery systems and herbal medicines: a review

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