Preparation and characterization of hydroxyapatite incorporated silica aerogel and its effect on normal human dermal fibroblast cells

Fabrication and characterization of dual layer PEBAX‐SiO2/polyethersulfone nanocomposite membranes for separation of CO2/CH4 gases

“…[47][48][49]51 Fumed silica is a nanoparticle with amorphous structure and shows a broad peak around 2θ = 21 . 49,52 This peak can be observed in an XRD pattern of PEBAX-5. However, the characteristic peak of PEBAX did not shift significantly but the intensity of PA peak was reduced by adding SiO 2 nanoparticles into the matrix which shows a decrease in PEBAX crystallinity.…”

Insights on toxicity, safe handling and disposal of silica aerogels and amorphous nanoparticles

“…Moreover, the dusty feature of silica aerogel particles can particularly produce a dry sensation in the skin and irritation by friction. [88][89][90][91][92][93][94][95][96][97] 99 Sol-gel and supercritical drying/SA: 470 to 750 m 2 g −1…”

“…91,93,95,[97][98][99][100][101][102][103] In general, silica-based aerogels presented good cytocompatibility with cell viabilities above 90% (Table 3) and have been even proposed as scaffolds to promote cell growth and proliferation for the ultimate goal of tissue growth or as artificial heart valve leaflets. [94][95][96]98,102,104 Silica aerogels have been also proposed as a non-cytotoxic and safe carrier or vector of different drugs (resveratrol, 5-fluorouracil, paclitaxel, methotrexate) for local and systemic administrations. [91][92][93]97 Interestingly, the biological response of some hybrid aerogels can differ from the behaviour of their individual counterparts.…”

“…99 The incorporation of increasing contents of hydroxyapatite (HA) in silica aerogel networks at weight ratios up to 1.3 also resulted in higher viabilities and growth of fibroblasts and osteoblasts than those of silica aerogel and hydroxyapatite individually, following increasing trends up to 0.5 where a maximum was reached. 94,95 Moreover, the incorporation of silica aerogel particles into certain polymeric materials (poly(ε-caprolactone)) may interfere in the cell regulation mechanisms. 101 Silica aerogel may neutralize acidic degradation products of polymers in the cell microenvironment with a beneficial effect on the cytocompatibility of the resulting material, although at the expense of a delayed cell growth at least at the early culture stages.…”

<p>Engineering of Aerogel-Based Biomaterials for Biomedical Applications</p>

“…23 Meanwhile, the inorganic materials and their composites have also been used for aerogel-based biomaterials, such as hydroxyapatite, silica, graphene. [21][22][23][24] It is easy to achieve a good biocompatibility by selecting the composition of aerogel-based biomaterials. For example, many aerogel-based biomaterials originated from decellularized tissues have shown the porous structure and high biocompatibility, and have been used to facilitate tissue regeneration in clinical applications.…”