Preparation and characterization of homogeneous chitosan–polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties

Cai, Xuan; Tong, Hua; Shen, Xinyu; Chen, Weixuan; Yan, Juan; Hu, Jiming

doi:10.1016/j.actbio.2009.03.005

Cited by 234 publications

(130 citation statements)

References 41 publications

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“…Another advantage of HAP is that it is biocompatible as implants and provides a biological scaffold for bone formation. However, a disadvantage of pure synthetic HAP is its low load bearing capacity, which can be alleviated somehow by the addition of another material such as polylactide (PLA) and collagen whereby the mechanical properties of the HAP composite biomaterials can be significantly improved [17][18][19]. Many organic and inorganic based composites, such as collagen-HAP, gelatin-HAP (Gel-HAP), Polylactide-HAP composites have been prepared and reported to have significant advantages over pure HAP [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite

Brundavanam

Jiang

Chapman

et al. 2011

Ultrasonics Sonochemistry

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Accepted ManuscriptThis is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Effect of Dilute Gelatine on the Ultrasonic Thermally AbstractA series of nano hydroxyapatite-gelatin composites with different dilute solutions of gelatin concentrations were synthesized by a thermally assisted low power ultrasonic irradiation method.The gelatine hydroxyapatite, (Gel-HAP) nanoparticles were prepared using Ca(NO 3 ) 2 and KH 2 PO 4 in the presence of gelatine in an aqueous solution. The synthesised products were heat treated between 100°C and 400°C. The effect of the addition of gelatin on the nucleation and growth of synthesised nano HAP was investigated. Characterisation was performed using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and Fourier transform infrared spectroscopy (FT-IR). The characterisation results indicate that gelatin has been appended to the nano HAP forming regular spherical shaped crystals of nano sized Gel-HAP.

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Section: Introductionmentioning

confidence: 99%

Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite

Brundavanam

Jiang

Chapman

et al. 2011

Ultrasonics Sonochemistry

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“…Various biocomposites of calcium orthophosphates with chitosan 298,482,500,512,527,565,[645][646][647][648][649][650][651][652][653]674,675,690,695,799,807,[811][812][813][814][815][816][817][818][819][820][821][822][823][824][825][826][827][828] and chitin 232,476,612,[829][830][831][832][833] are also very popular. For example, a solutionbased method was developed to combine HA powders with chitin, in which the ceramic particles were uniformly dispersed.…”

Section: 725mentioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

152

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“…The physicochemical properties of HA nanocrystals prepared in organic polymers is highly dependent on the experimental condition such as pH value and subsequently on the degree of ionization of functional groups of the polymers [8]. Because of the biocompatibility, biodegradability and high mechanical strength of this composite, it was used as tissue scaffold, and in reinforcing applications [9]. Generally, there is several ways to produce such composite materials either by mixing the solid inorganic powder with organic polymer or by preparing in situ preparing the inorganic materials from their ionic precursors in the polymer.…”

Section: Mai K Hassan Et Almentioning

confidence: 99%

The Effect of Different Solvents for Chitosan Solubilization on The Crystal Growth of in situ Prepared Hydroxyapatite

2017

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C HITOSAN/hydroxyapatite (CS/HA) nanocomposites have been widely fabricated for potential use in bone defects due to their high biocompatibility and similarity to the natural bone. In the current study, HA nanocrystals were prepared by co-precipitation method in CS which was initially dissolved in different concentrations of acrylic acid and acetic acid (2 and 4 %). The effect of chitosan solvents on the morphology of HA nanocrystals, the crystallite sizes, and the physical binding with CS were investigated by different techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and transmission electron microscope (TEM). The FT-IR and XPS results showed that the interaction between CS and HA in the nanocomposites is predominantly dependent on the type of solvent used to dissolve CS. When acetic acid was used, the interaction between CS and HA was stronger when compared to acrylic acid. Quantitative XPS results showed that the atomic percentage of nitrogen (N1s) of the amine groups of CS was less in the case of the composites prepared after dissolving CS in acrylic acid compared to acetic acid. The amine groups of CS (−NH 2 ) can start the nucleation of HA crystals and remain bounded to the surface of the grown crystal through chelation with calcium ions on the crystal facets. In both organic solvents, HA crystals were found to grow along their c-axis direction into rodshape but the growth in the width was more restricted in case of acetic acid. The results in the current study indicated that the type of CS solvents is determining the strength of the physical interaction between the CS and HA. This might be a crucial factor to control and enhance the mechanical and the biological behaviors of the nanocomposites.

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Preparation and characterization of homogeneous chitosan–polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties

Cited by 234 publications

References 41 publications

Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite

Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite

Biocomposites and hybrid biomaterials based on calcium orthophosphates

The Effect of Different Solvents for Chitosan Solubilization on The Crystal Growth of in situ Prepared Hydroxyapatite

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