Preparation and Characterization of High Mechanical Strength Chitosan/Oxidized Tannic Acid Composite Film with Schiff Base and Hydrogen Bond Crosslinking

Qin, Zhiyong; Huang, Youjia; Xiao, Siyu; Zhang, Haoyu; Lu, Yunlong; Kong, Xu

doi:10.3390/ijms23169284

Cited by 17 publications

(5 citation statements)

References 46 publications

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“…As mentioned, the synthesis of OTA was synthesized via laccase oxidization to generate quinone in situ by oxidation of accessible tyrosyl grafted phenol units [26]. Such reaction preferentially oxidized the phenolic hydroxyl group of the TA structure to become reactive o-quinones, which was validated in literature [50]. TA as a stabilizer to prepare TA modified AuNPs was also explored [25].…”

Section: Discussionmentioning

confidence: 96%

Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson’s disease

Chen

Tai

et al. 2023

Biomater Res

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Background Parkinson’s disease (PD) is one of the most common long-term neurodegenerative diseases. Current treatments for PD are mostly based on surgery and medication because of the limitation and challenges in selecting proper biomaterials. In this study, an injectable bioactive hydrogel based on novel tannic acid crosslinker was developed to treat PD. Methods The oxidized tannic acid modified gold nano-crosslinker was synthesized and used to effectively crosslink chitosan for preparation of the bioactive self-healing hydrogel. The crosslinking density, conductivity, self-healing ability, and injectability of the hydrogel were characterized. Abilities of the hydrogel to promote the proliferation and differentiation of neural stem cells (NSCs) were assessed in vitro. Anti-inflammatory property was analyzed on J774A.1 macrophages. The hydrogel was injected in the PD rat model for evaluation of the motor function recovery, electrophysiological performance improvement, and histological repair. Results The hydrogel exhibited self-healing property and 34G (~ 80 μm) needle injectability. NSCs grown in the hydrogel displayed long-term proliferation and differentiation toward neurons in vitro. Besides, the hydrogel owned strong anti-inflammatory and antioxidative capabilities to rescue inflamed NSCs (~ 90%). Brain injection of the bioactive hydrogel recovered the motor function of PD rats. Electrophysiological measurements showed evident alleviation of irregular discharge of nerve cells in the subthalamic nucleus of PD rats administered with the hydrogel. Histological examination confirmed that the hydrogel alone significantly increased the density of tyrosine hydroxylase positive neurons and fibers as well as reduced inflammation, with a high efficacy similar to drug-loaded hydrogel. Conclusion The new bioactive hydrogel serves as an effective brain injectable implant to treat PD and a promising biomaterial for developing novel strategies to treat brain diseases. Graphical Abstract

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Section: Discussionmentioning

confidence: 96%

Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson’s disease

Chen

Tai

et al. 2023

Biomater Res

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“…The composite films have good hydrophilicity, water absorption, elasticity, biocompatibility, thermal stability, and antibacterial effect. Qin et al [104] prepared CS/tannic acid (CTA) and CS/oxidized tannic acid (COTA) composite membranes by the tape method. The results showed that the composite film had excellent mechanical properties and antibacterial properties, and it had an obvious antibacterial effect on Escherichia coli.…”

Section: Schiff Alkalization Reactionmentioning

confidence: 99%

Harnessing the Potential of Chitosan and Its Derivatives for Enhanced Functionalities in Food Applications

Yi,

Miao,

Yang

et al. 2024

Foods

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As one of the most abundant natural polysaccharides that possess good biological activity, chitosan is extracted from chitin. Its application in the food field is being increasingly valued. However, chitosan extraction is difficult, and its poor solubility limits its application. At present, the extraction methods include the acid–base method, new chemical methods, and biological methods. The extraction rates of chitin/chitosan are 4–55%, 13–14%, and 15–28%, respectively. Different chemical modifications have different effects on chitosan, making it applicable in different fields. This article reviews and compares the extraction and chemical modification methods of chitosan, emphasizing the importance of green extraction methods. Finally, the application prospects of chitosan in the food industry are discussed. This will promote the understanding of the advantages and disadvantages of different extraction methods for chitosan as well as the relationship between modification and application, providing valuable insights for the future development of chitosan.

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“…No significant differences in the elongation at break values were observed between the studied samples. Qin et al [61] observed that the addition of tannic acid to chitosan results in an increase in tensile strength as well as the Young Modulus. 0Also, Sun et al [62] documented that the presence of gallic acid results in a significant increase in the tensile strength of the studied chitosan/gallic acid films.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Application Potential of Trichoderma in the Degradation of Phenolic Acid-Modified Chitosan

Swiontek Brzezinska,

Kaczmarek-Szczepańska,

Dąbrowska

et al. 2023

Foods

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The aim of the study was to determine the potential use of fungi of the genus Trichoderma for the degradation of phenolic acid-modified chitosan in compost. At the same time, the enzymatic activity in the compost was checked after the application of a preparation containing a suspension of the fungi Trichoderma (spores concentration 105/mL). The Trichoderma strains were characterized by high lipase and aminopeptidase activity, chitinase, and β-1,3-glucanases. T. atroviride TN1 and T. citrinoviride TN3 metabolized the modified chitosan films best. Biodegradation of modified chitosan films by native microorganisms in the compost was significantly less effective than after the application of a formulation composed of Trichoderma TN1 and TN3. Bioaugmentation with a Trichoderma preparation had a significant effect on the activity of all enzymes in the compost. The highest oxygen consumption in the presence of chitosan with tannic acid film was found after the application of the consortium of these strains (861 mg O2/kg after 21 days of incubation). Similarly, chitosan with gallic acid and chitosan with ferulic acid were found after the application of the consortium of these strains (849 mgO2/kg and 725 mg O2/kg after 21 days of incubation). The use of the Trichoderma consortium significantly increased the chitinase activity. The application of Trichoderma also offers many possibilities in sustainable agriculture. Trichoderma can not only degrade chitosan films, but also protect plants against fungal pathogens by synthesizing chitinases and β-1,3 glucanases with antifungal properties.

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Preparation and Characterization of High Mechanical Strength Chitosan/Oxidized Tannic Acid Composite Film with Schiff Base and Hydrogen Bond Crosslinking

Cited by 17 publications

References 46 publications

Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson’s disease

Bioactive self-healing hydrogel based on tannic acid modified gold nano-crosslinker as an injectable brain implant for treating Parkinson’s disease

Harnessing the Potential of Chitosan and Its Derivatives for Enhanced Functionalities in Food Applications

Application Potential of Trichoderma in the Degradation of Phenolic Acid-Modified Chitosan

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