Preparation and characterization of HAP/carboxymethyl chitosan nanocomposites

Abstract

Nanocomposites of modified chitosan, carboxymethyl chitosan (CMCh) with hydroxyapatite (HAP) have been prepared by coprecipitation technique. Totally three nanocomposites containing 80/20, 50/50, and 20/80 of HAP/CMCh have been prepared and were characterized by using transmission electron microscopy (TEM), X-ray diffraction (XRD), fourier transformed infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), thermogravimetry (TG), and scanning electron microscopy (SEM). Modified chitosan, CMCh, which is water soluble can be used for drug delivery application. TEM micrographs of the nanocomposites revealed the formation of small HAP crystallites of about 230 nm in length and 30 nm in width that are aggregated to form elliptical shapes or morphology. TGA thermograms showed that the thermal stability of the CMCh increased with incorporation of HAP. FTIR, XRD, and XPS analysis of CMCh/HAP nanocomposites showed the peaks corresponding to CMCh as well as HAP and confirm the formation of HAP/CMCh nanocomposites.

Biocomposites and hybrid biomaterials based on calcium orthophosphates

“…Various biocomposites of calcium orthophosphates with chitosan 298,482,500,512,527,565,[645][646][647][648][649][650][651][652][653]674,675,690,695,799,807,[811][812][813][814][815][816][817][818][819][820][821][822][823][824][825][826][827][828] and chitin 232,476,612,[829][830][831][832][833] are also very popular. For example, a solutionbased method was developed to combine HA powders with chitin, in which the ceramic particles were uniformly dispersed.…”

Green synthesis of gum-acacia assisted gold-hydroxyapatite nanostructures – Characterization and catalytic activity

“…HAp-polymer composites such as HAp-gelatin, HAp-collagen, HAp/collagen-alginate, HAp-polypropylene [37] and HAp-chitosan are reported in the literature [38]. In an earlier work from our group, modified chitosan (carboxymethyl chitosan (CMCh)) was used to synthesize HAp by coprecipitation method that resulted in the formation of novel nanocomposite [39]. The development of facile, green, surfactantfree, HAp nanostructure with uniform size distribution by controlling the growth and the morphology still remains a challenge.…”

“…It is a mixture of calcium, magnesium and potassium salt of a polysaccharide acid and composed of carbohydrate moieties (galactopyranose, arabinopyranose, arabinofuranose, rhamnopyranose, glucopyranosyl uronic acid and 4-O methyl glucopyranosyl uronic acid) with a small portion of hydroxyproline rich protein [40]. It is a good emulsifying, stabilizing and dispersing agent due to electrostatic interactions between negatively charged groups from GA and positive sites on the oxide surface [39,41]. Our previous studies on GA explain the basic structure as well as good reducing and stabilizing properties in formation of metal nanoparticles [42,43].…”

Photo-polymeriable chitosan derivative prepared by Michael reaction of chitosan and polyethylene glycol diacrylate (PEGDA)

“…Recently, various kinds of chemical modification of chitosan, such as akylation reaction [11], quaternary reaction [12], carboxymethyl reaction [13], ring-opening reaction [14] and acylate reaction [15,16] to provide water-soluble or organic-soluble productions are of prime interest to generate novel biomaterials, Many research reported on the chitosan derivative applications in the fields of biomaterials such as soft tissue reconstruction [17], cartilage tissue engineering in recent years [18], cartilage regeneration [19], and drug release [20]. But the procedure of the methods was complex, the cost was high, and toxic segment was introduced during the process which changes the properties of the chitosan derivative at all.…”