Preparation and characterization of free films of high amylose/pectin mixtures cross-linked with sodium trimetaphosphate

Abstract

High amylose and pectin were mixed at 1:1 mass ratio and cross-linked with sodium trimetaphosphate (STMP) in alkaline medium. Films were prepared from aqueous dispersions of these cross-linked polymer blend at three different concentrations (3, 4 and 5%), by solvent casting method. Characterization of the films included thickness, surface morphology, water uptake, water vapor permeability (WVP), tensile strength measurements and enzymatic digestion. The cross-linking allowed to obtain films with improved mechanical properties and reduced WVP. The high resistance to enzymatic digestion exhibited by these films represents a promising approach to their application in the development of colon drug delivery systems.

Films from resistant starch-pectin dispersions intended for colonic drug delivery

“…This technique has been used successfully by our research group in other types of systems (Carbinatto et al, 2012;Cury, Castro, & Evangelista, 2009;Prezotti et al, 2012;Soares, Castro, Cury, & Evangelista, 2013).…”

“…The profile of liquid uptake of free films was evaluated on an Enslin device (Prezotti et al, 2012;Voigt, 2000). Pieces of films (about 1 cm 2 ) were accurately weighed and carefully poured on the sintered glass filter of funnel.…”

“…In this sense, the use of blends of already known polymers represents a rational approach to obtain materials with modulated properties to enable them for specific therapeutic goals, avoiding the high costs involved in the synthesis and characterization of completely new materials (Carbinatto, Castro, Cury, Magalhães, & Evangelista, 2012;Ebude & Jones, 2004;Lecomte, Siepmann, Walther, Macrae, & Bodmeier, 2005;Patel & Patel, 2007;Prezotti, Meneguin, Evangelista, & Cury, 2012;Silva, Bierhalz, & Kieckbusch, 2009;Wang, Hu, Du, & Kennedy, 2010).…”

Enhanced colonic delivery of ciclosporin A self-emulsifying drug delivery system encapsulated in coated minispheres

“…The goal of the current study is to evaluate the potential of polymer coated minispheres to achieve enhanced colonic CsA tissue concentrations while limiting systemic bioavailability. Polysaccharide-based coatings, such as ethylcellulose and pectin have previously been utilized for colonic drug delivery due in part to their safety, low toxicity profile and availability [19][20][21] . Many of these polysaccharides can be chemically modified or combined with other polymers to enhance release in the colon.…”

A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability

“…The liquid uptake ability was assessed using an Enslin device (Cury et al, 2009;Prezotti et al, 2012). An accurately weighted mass of SD (0.05 g) was uniformly spread on a sintered glass filter.…”