Preparation and characterization of Fe doped n-hydroxyapatite for biomedical application

Jose, Suja; Senthilkumar, M.; Kolanthai, Elayaraja; Haris, M.; George, Amal; Raj, A. Dhayal; Sundaram, S. John; Bashir, A.K.H.; Maaza, M.; Kaviyarasu, K.

doi:10.1016/j.surfin.2021.101185

Cited by 21 publications

(21 citation statements)

References 16 publications

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“…The cell wall structure of E. coli is more complex than that of S. aureus [ 56 ], and thus Cu 2+ , Mg 2+ , and Zn 2+ ions can barely disrupt the cell wall of E. coli and hardly exert a bacteriostatic effect [ 57 , 58 ]. In addition, nanoapatites with low concentrations of Cu 2+ ions exhibited better bacteriostatic effects than those with Mg 2+ and Zn 2+ [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, our study and some other studies have shown that nanoapatites are more active against gram-positive bacteria than against gram-negative bacteria ( Figure 4 and Figure 5 ). This difference may be related to the difference in cell wall structure between the bacterial types [ 56 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…The nanoapatite groups with Cu 2+ showed cytotoxicity, whereas nanoapatites with Mg 2+ and Zn 2+ and the 7Mg−nHA, 3Zn−nHA, 5Zn−nHA, and 7Zn−nHA groups still showed cytotoxicity [62]. The cell morphology in Figure 6b was qualitatively analyzed, and the results of each group showed the same trend as the quantitative analy- The cell wall structure of E. coli is more complex than that of S. aureus [56], and thus Cu 2+ , Mg 2+ , and Zn 2+ ions can barely disrupt the cell wall of E. coli and hardly exert a bacteriostatic effect [57,58]. In addition, nanoapatites with low concentrations of Cu 2+ ions exhibited better bacteriostatic effects than those with Mg 2+ and Zn 2+ [59].…”

Section: Cytotoxicitymentioning

confidence: 88%

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Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

et al. 2022

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The objective of this study was to prepare hydroxyapatite (HA) with potential antibacterial activity against gram-negative and gram-positive bacteria by incorporating different atomic ratios of Cu2+ (0.1–1.0%), Mg2+ (1.0–7.0%), and Zn2+ (1.0–7.0%) to theoretically replace Ca2+ ions during the hydrothermal synthesis of grown precipitated HA nanorods. This study highlights the role of comparing different metal ions on synthetic nanoapatite in regulating the antibacterial properties and toxicity. The comparisons between infrared spectra and between diffractograms have confirmed that metal ions do not affect the formation of HA phases. The results show that after doped Cu2+, Mg2+, and Zn2+ ions replace Ca2+, the ionic radius is almost the same, but significantly smaller than that of the original Ca2+ ions, and the substitution effect causes the lattice distance to change, resulting in crystal structure distortion and reducing crystallinity. The reduction in the length of the nanopatites after the incorporation of Cu2+, Mg2+, and Zn2+ ions confirmed that the metal ions were mainly substituted during the growth of the rod-shape nanoapatite Ca2+ distributed along the longitudinal site. The antibacterial results show that nanoapatite containing Cu2+ (0.1%), Mg2+ (3%), and Zn2+ (5–7%) has obvious and higher antibacterial activity against gram-positive bacteria Staphylococcus aureus within 2 days. The antibacterial effect against the gram-negative bacillus Escherichia coli is not as pronounced as against Staphylococcus aureus. The antibacterial effect of Cu2+ substituted Ca2+ with an atomic ratio of 0.1~1.0% is even better than that of Mg2+- and Zn2+- doped with 1~7% groups. In terms of cytotoxicity, nanoapatites with Cu2+ (~0.2%) exhibit cytotoxicity, whereas Mg2+- (1–5%) and Zn2+- (~1%) doped nanoapatites are biocompatible at low concentrations but become cytotoxic as ionic concentration increases. The results show that the hydrothermally synthesized nanoapatite combined with Cu2+ (0.2%), Mg2+ (3%), and Zn2+ (3%) exhibits low toxicity and high antibacterial activity, which provides a good prospect for bypassing antibiotics for future biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Cytotoxicitymentioning

confidence: 88%

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Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

et al. 2022

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“…Katkılama, arzulanan özelliklere ve işlevlere sahip malzemeler elde etmenin etkili bir yoludur. Literatürde hidroksiapatit yapıya Fe [34], Gd [35], Sr [31], Zr [36], Al [37], Ag [38], Cr [39], Mn [40,41] gibi elementlerin katkılamasının yapıldığı çalışmalar bulunmaktadır. Muthuselvi ve ark.…”

Section: Introductionunclassified

Synthesis and Characterization of NiO Reinforced Mn Based Hydroxyapatite Composites

Ateş

Keser

Korkmaz

et al. 2022

International Journal of Innovative Engineering Applications

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Original scientific paperIn this study, the composite samples formed by using manganese (Mn) based hydroxyapatite (HAp) synthesized by hydrothermal method and nickel oxide (NiO) produced by the wet chemical method were characterized. NiO reinforcement was found to be effective on crystallization, lattice parameters, and average crystal size of Mn-doped HAp. The crystallite sizes of the samples were calculated in the range of 24.64 nm to 33.72 nm. The crystallization values of the samples were found between 77.36% and 86.4%. It was observed that it can possible to change and control some properties of Mn-doped HAp with the addition of NiO. Thus, it is thought that the as-synthesized materials will add an innovation to the literature and will be aimed to investigate their usability for different applications.

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“…Drinkable water is often contaminated with microbes for instance; Escherichia coli (E. coli).Harmful strains of E. coli ingested in human body by various means can cause diarrhea, vomiting, severe anemia, kidney failure, urinary tract infections, and other infections [26]. Different concentrations of Fe doped HAp powder was mixed with amoxicillin powder in the ratio of 1: 0.5 showed a good inhibitory effect against gram negative bacteria E. coli reported by [27]. The aim of this study work was to synthesis high purity HAp and Fe doped HAp using urea as fuel and investigates their efficacy for defluoridation of water and antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Iron Doped Hydroxyapatite for Defluoridation of Water and Antibacterial Activity

Temtime

Zereffa

Leku

2022

Preprint

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Fluoride contaminated drinking water is a major concern due to its negative health effects experienced by people in many parts of the world. This study focused on the synthesis of HAp and Fe doped HAp from diammonium hydrogen phosphate (DAP), calcium and iron precursors using urea as fuel for defluoridation of water and antibacterial activities. The synthesis of HAp and Fe doped HAp were characterized by using thermogravimetric analysis; scanning electron microscopy, X-ray diffraction, and Fourier transform Infrared spectroscopic techniques. An average crystallite size of HAp and Fe doped HAp were 32.54 nm and 27.91 nm, respectively, showing Fe doping results in a decrease in crystallite size. Batch adsorption studies were performed to investigate the adsorption capacity and removal efficiency of hydroxyapatite such as the effect of the initial pH of the solution, contact time, adsorbent dose and initial fluoride concentration. The adsorption data were fitted by Freundlich isotherm model and pseudo second order kinetic. In real water samples, the maximum removal efficiency of fluoride was observed to be 82.9 % with 4.2 mg/g maximum adsorption capacity under the optimum conditions which indicated that the prepared hydroxyapatite can be used as adsorbents for the removal of fluoride from contaminated real water with good efficiency. The antibacterial activities of the synthesized HAp and Fe doped HAp were tested against gram-negative bacterial strains E. coli and against gram-positive bacterial strains S. aureus using disc diffusion method. The maximum inhibition zone of gram-negative bacterial strains E. coli was 11 mm for both HAp and Fe doped HAp.

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Preparation and characterization of Fe doped n-hydroxyapatite for biomedical application

Cited by 21 publications

References 16 publications

Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

Synthesis and Characterization of NiO Reinforced Mn Based Hydroxyapatite Composites

Synthesis and Characterization of Iron Doped Hydroxyapatite for Defluoridation of Water and Antibacterial Activity

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