Preparation and characterization of extracellular vesicles and their cutting-edge applications in regenerative medicine

Tang, Pei; Song, Fengqin; Chen, Yang; Gao, Canyu; Ran, Xiaolin; Li, Yang; Chen, Zhixing; Zhang, Zhenyu; Wei, Wei; Peng, Zhiyu; Li, Zhengyong; Zhou, Changchun

doi:10.1016/j.apmt.2024.102084

Cited by 1 publication

(1 citation statement)

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“…Additionally, the implementation of robust quality control measures throughout the production process, including rigorous validation of reagents, equipment calibration, and documentation of procedures, is essential to ensure the reliability and safety of MSC-EV-based therapies. By establishing technical standards and quality control systems, the field can enhance the reliability and comparability of research outcomes, accelerate the translation of MSC-EV-based therapies into clinical practice, and ultimately maximize their potential to improve patient outcomes ( Kolenc and Maličev, 2024 ; Tang et al, 2024 ).…”

Section: Discussionmentioning

confidence: 99%

Regulation of the Nrf2/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: implications for disease treatment

Su,

Wang,

Zhou

et al. 2024

Front. Cell Dev. Biol.

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This comprehensive review inspects the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) across multiple organ systems. Examining their impact on the integumentary, respiratory, cardiovascular, urinary, and skeletal systems, the study highlights the versatility of MSC-EVs in addressing diverse medical conditions. Key pathways, such as Nrf2/HO-1, consistently emerge as central mediators of their antioxidative and anti-inflammatory effects. From expediting diabetic wound healing to mitigating oxidative stress-induced skin injuries, alleviating acute lung injuries, and even offering solutions for conditions like myocardial infarction and renal ischemia-reperfusion injury, MSC-EVs demonstrate promising therapeutic efficacy. Their adaptability to different administration routes and identifying specific factors opens avenues for innovative regenerative strategies. This review positions MSC-EVs as promising candidates for future clinical applications, providing a comprehensive overview of their potential impact on regenerative medicine.

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Section: Discussionmentioning

confidence: 99%