Abstract:Nanoparticles with the dimensions of circa 50 nm prepared from the micellar aggregation of diblock copolymers of poly(ethylene oxide) and polycaprolactone (PEO-b-PCL) were explored as a parenteral carrier system for water-soluble organic drugs in salt form. Enalapril maleate (EPM), developed for hypertension and congestive heart failure, was used as a model drug. The nanoparticles from three block copolymers with compositions of 5k-7.5k, 5k-5k, and 5k-2.5k (PEO-b-PCL) exhibited drugloading efficiency of 38%, 4… Show more
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