Preparation and Characterization of Electrospun Blend Fibrous Polyethylene Oxide:Polycaprolactone Scaffolds to Promote Cartilage Regeneration

Mirzaei, Zeynab; Kordestani, Soheila S.; Kuth, Sonja; Schubert, Dirk; Detsch, Rainer; Roether, Judith A.; Blunk, Torsten; Boccaccını, Aldo R.

doi:10.1002/adem.202000131

Cited by 10 publications

(2 citation statements)

References 70 publications

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“…15,16 Thus, the ROP of PCL can be carried out by using hydrophilic polymers such as polyethylene oxide (PEO) as macroinitiators, producing amphiphilic block copolymers. [17][18][19][20][21] As previously commented, the M/I ratio in the feed also can be tuned to obtain by ROP block copolymers with different hydrophilic and/or hydrophobic block lengths. 22 PCL can be used for obtaining polymeric materials, and there is a plethora of polymer processing techniques to produce these materials.…”

Section: Introductionmentioning

confidence: 97%

Tuning the properties of polycaprolactone-based fibers by using polyethylene oxide / polycaprolactone block copolymers

Cárdenas,

Fernández,

Romero-Araya

et al. 2024

J Polym Res

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Section: Introductionmentioning

confidence: 97%

Tuning the properties of polycaprolactone-based fibers by using polyethylene oxide / polycaprolactone block copolymers

Cárdenas,

Fernández,

Romero-Araya

et al. 2024

J Polym Res

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“…[5] The shortage of bone grafts and tissues, immune rejection, and pathogen transfer paved the way for rapid growth in the field of bone tissue engineering. [6][7][8] Tissue engineering is a multidisciplinary approach to recreating functional tissues and organs after trauma, end-stage organ failure, or congenital defects. [9][10][11] The main aim of bone tissue engineering is to retrieve the task of bone tissues by combining various factors such as cell biology, material science, and engineering principles.…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional printing of triply periodic minimal surface structured scaffolds for load‐bearing bone defects

Agarwal

Malhotra

Gupta

et al. 2023

Polymer Engineering & Sci

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The porous and cellular architecture of scaffolds plays a significant role in mechanical strength and bone regeneration during the healing of fractured bones. In this present study, triply periodic minimal surface (TPMS)-based gyroid and primitive lattice structures were used to design the cellular porous biomimetic scaffolds with different unit cell sizes (4, 5, and 6). The fused filament fabrication-based 3D printing technology was used for the fabrication of polylactic acid scaffolds. The surface morphology and mechanical compressive strength of differently structured scaffolds were observed using scanning electron microscopy and a universal testing machine. The unit cell size of 4 showed higher compressive strength in both gyroid and primitive structured scaffolds compared to unit cell sizes 5 and 6. Moreover, the gyroid structured scaffolds have higher compressive strengths as compared to primitive structured scaffolds due to the higher bonding surface area at the intercalated layers of the scaffold. Hence, the mechanical strength of scaffolds can be tailored by varying the unit cell size and cellular structures to avoid stress shielding and ensure implant safety. These TPMS-based scaffolds are promising and can be used as bone substitute materials in tissue engineering and orthopedic applications.

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Pathogenesis‐Guided Engineering: pH‐Responsive Imprinted Polymer Co‐Delivering Folate for Inflammation‐Resolving as Immunotherapy in Implant‐Related Infections

Costa,

Nagay,

Villa

et al. 2024

Adv Funct Materials

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Folate (FT) is a suitable targeting ligand for folate receptors (FOLR) overexpressed on inflamed cells. Thus, FT‐loaded polymers can be used as FOLRs‐targeted immunotherapy to positively modulate the inflammatory process. A novel biodegradable imprinted polymer with a FT delivery mechanism driven by pH changes [PCL‐MIP@FT] is designed with molecularly imprinted technology. The pH mechanism is validated in vitro, demonstrating that an acidic environment accelerated and increased the release of FT for a period of 7 days (∼100 µg mL−1). For the first time, FT receptors (FOLR‐1 and FOLR‐3) are discovered and also overexpressed on activated human gingival fibroblasts, representing a favorable target in the oral environment. Although FT itself does not have antimicrobial effects, the nanomechanical properties of biofilm are changed after topical FT administration. In vivo systemic toxicity of PCL‐MIP@FT has been demonstrated to be a safe biomaterial (up to 1.3 mg kg−1). When the PCL‐MIP@FT is assessed in the subcutaneous tissue, it promoted an alleviating inflammation and may be able to stimulate tissue repair. The present findings have demonstrated the reliable in vitro and in vivo anti‐inflammatory actions of FT‐loaded polymer and support its use as a novel drug‐free therapeutic platform for modulating and mitigating inflammatory responses in dental implant‐related infections.

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Preparation and Characterization of Electrospun Blend Fibrous Polyethylene Oxide:Polycaprolactone Scaffolds to Promote Cartilage Regeneration

Cited by 10 publications

References 70 publications

Tuning the properties of polycaprolactone-based fibers by using polyethylene oxide / polycaprolactone block copolymers

Tuning the properties of polycaprolactone-based fibers by using polyethylene oxide / polycaprolactone block copolymers

Three‐dimensional printing of triply periodic minimal surface structured scaffolds for load‐bearing bone defects

Pathogenesis‐Guided Engineering: pH‐Responsive Imprinted Polymer Co‐Delivering Folate for Inflammation‐Resolving as Immunotherapy in Implant‐Related Infections

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