Preparation and characterization of electrospun polylactic acid/sodium alginate/orange oyster shell composite nanofiber for biomedical application

Cesur, Sümeyye; Oktar, Faik N.; Ekren, Nazmi; Kılıç, Osman; Alkaya, Dilek Bilğiç; Seyhan, Serap Ayaz; Ege, Zeynep Ruya; Lin, Chun‐Cheng; Kuruca, Serap Erdem; Erdemir, Gökçe; Gündüz, Oğuzhan

doi:10.1007/s41779-019-00363-1

Cited by 50 publications

(33 citation statements)

References 46 publications

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“…SA shows characteristic stretching vibrations of O-H peak at 3334 cm −1 and the literature also proves that this characteristic band is found in the range of 3000-3600 cm −1 [40,41]. Asymmetric stretching vibration of -COO-groups peak at 1593 cm −1 , symmetric stretching vibration of -COO-groups peak at 1419 cm −1 and -C-O-C-stretching vibration peaks at 1078 cm −1 were obtained [42][43][44].…”

Section: Fourier-transform Infrared Spectroscopy (Ft-ir)supporting

confidence: 55%

3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

Aranci

Uzun

et al. 2020

Molecules

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In this study, the main aim was to fabricate propolis (Ps)-containing wound dressing patches using 3D printing technology. Different combinations and structures of propolis (Ps)-incorporated sodium alginate (SA) scaffolds were developed. The morphological studies showed that the porosity of developed scaffolds was optimized when 20% (v/v) of Ps was added to the solution. The pore sizes decreased by increasing Ps concentration up to a certain level due to its adhesive properties. The mechanical, swelling-degradation (weight loss) behaviors, and Ps release kinetics were highlighted for the scaffold stability. An antimicrobial assay was employed to test and screen antimicrobial behavior of Ps against Escherichia coli and Staphylococcus aureus strains. The results show that the Ps-added scaffolds have an excellent antibacterial activity because of Ps compounds. An in vitro cytotoxicity test was also applied on the scaffold by using the extract method on the human dermal fibroblasts (HFFF2) cell line. The 3D-printed SA–Ps scaffolds are very useful structures for wound dressing applications.

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Section: Fourier-transform Infrared Spectroscopy (Ft-ir)supporting

confidence: 55%

3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

Aranci

Uzun

et al. 2020

Molecules

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“…[269] In another work, emulsion electrospinning was used to develop alginate-PLA NFs enriched with tricalcium phosphate nano-clays derived from the orange oyster shell. [270] These hybrid NFs displayed a smooth and bead-less surface, superior mechanical properties, biocompatibility, and good capability to foster bone cell viability. Again, alginate-pullulan NFs were fabricated via free surface electrospinning without the use of any co-spinning agent and undesirable organic solvents, hence showing promises for biomedical purposes.…”

Section: Tissue Engineering and Wound Healingmentioning

confidence: 99%

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

Dodero

Alberti

Gaggero

et al. 2021

Adv Materials Inter

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along with other polysaccharides (e.g., celluloses, chitosan, etc.), is indeed considered an extremely promising material in the viewpoint of circular economy and in substituting petroleum-derived polymers. [3] Among others, one of the reasons for alginate success is its unique capability to bind different cations leading to stable and tailor-made hydrogels. [4] Owing to its biocompatibility, biodegradability, and nontoxicity, in the past decades alginate has been vastly explored for drug and gene delivery, tissue engineering, and wound healing applications. [5] In this sense, the recent nanotechnological advances have allowed the fabrication and exploitation of alginate-based nanostructured materials with completely new capabilities. Thereby, it is not surprising that nowadays a broad variety of alginate-based nanomaterials with various shapes, sizes, and compositions are prepared via different approaches, including controlled gelation, electrospinning and electrospraying, self-assembly, phase-separation, and micro fluidics., All these nanostructures hold the potential to interact with living organisms much more efficiently with respect to bulk systems, hence leading to specific functionalities at the same time avoiding the occurrence of toxicity issues. [6][7][8] Despite the use of alginate-based nanomaterials has been reviewed in the past, the focus has been commonly pointed to their generic properties and applications. Conversely, this review attempts to provide a more specific and comprehensive summary limited to the most recent advances in the fabrication and use of two of the most common and promising alginatebased nanomaterials, namely nanoparticles (NPs) and electrospun nanofibers (NFs), with a focus on biomedical and pharmaceutical applications.

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“…PLGA polymer has been widely used in drug delivery systems (DDS) and tissue engineering scaffolds. PLGA is approved by the US food and drug administration (FDA) as biodegradable polymers being subjected to the metabolism in vivo [122][123][124][125][126]. The hydroxyapatite (HAp) particles could be incorporated into PLGA nanofibers to construct a biomimetic 3D nanofiber scaffold used to culture breast cancer cells.…”

Section: Synthetic 3d Structures and 3d Bioprinting Technologymentioning

confidence: 99%

Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro

et al. 2020

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Defined by its potential for self-renewal, differentiation and tumorigenicity, cancer stem cells (CSCs) are considered responsible for drug resistance and relapse. To understand the behavior of CSC, the effects of the microenvironment in each tissue are a matter of great concerns for scientists in cancer biology. However, there are many complicated obstacles in the mimicking the microenvironment of CSCs even with current advanced technology. In this context, novel biomaterials have widely been assessed as in vitro platforms for their ability to mimic cancer microenvironment. These efforts should be successful to identify and characterize various CSCs specific in each type of cancer. Therefore, extracellular matrix scaffolds made of biomaterial will modulate the interactions and facilitate the investigation of CSC associated with biological phenomena simplifying the complexity of the microenvironment. In this review, we summarize latest advances in biomaterial scaffolds, which are exploited to mimic CSC microenvironment, and their chemical and biological requirements with discussion. The discussion includes the possible effects on both cells in tumors and microenvironment to propose what the critical factors are in controlling the CSC microenvironment focusing the future investigation. Our insights on their availability in drug screening will also follow the discussion.

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Preparation and characterization of electrospun polylactic acid/sodium alginate/orange oyster shell composite nanofiber for biomedical application

Cited by 50 publications

References 46 publications

3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro

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