Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin

Cheng, Ziting; Lin, Hua; Wang, Zhen; Yang, Xiao‐Yu; Zhang, Mei; Liu, Xuechun; Wang, Bingjie; Wu, Zhenfeng; Chen, Daquan

doi:10.1007/s13346-020-00735-2

Cited by 51 publications

(19 citation statements)

References 38 publications

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“…Since this method was validated in 2014 by Larrañeta et al [95], this model was only cited in the included studies from 2017 onwards. The other alternative methods to using skin were mentioned from 2019 (gelatin) and 2020 (agarose and aluminum foil) [65,88].…”

Section: Mechanical Properties In Vitro Assaysmentioning

confidence: 99%

“…The agitation speed of the receptor fluid varied from 100 to 600 rpm. Regarding the assay time, the in vitro permeation assay demonstrated longer sample collection intervals, owing to the construction of the dermatokinetic profiles of the compounds [38,41,69,88]. The graphical distribution of the variables described by a number of studies is shown in Figure 6A.…”

Section: Mechanical Properties In Vitro Assaysmentioning

confidence: 99%

“…Some studies employed micro-needles containing the substances in their free form, i.e., without the presence of nanostructured systems [41,54,69,77]. Additionally, one study evaluated the modification of the polymeric composition on the permeation profile by applying MNs of hyaluronic acid and micelles without the presence of CMC [88]. The other studies applied the nanostructured systems in suspension or solution on the skin [51,77,87], and one study applied a suspension of the nanostructured system after the microporation of the skin with solid MNs.…”

Section: Mechanical Properties In Vitro Assaysmentioning

confidence: 99%

“…Regarding skin insertion assays, assay features in terms of application mode and force employed were described more frequently in the in vitro studies than in the in vivo studies. Furthermore, it was verified that the studies assigned manual force values of 1.5 to 30 N [48,79,88]. In an attempt to standardize manual strength, Larrateña et al measured the manual force of 20 volunteers (10 males and 10 females) by pressing their thumbs on the TA.XTPlus Texture Analyser (Stable Micro Systems) platform and holding the pressure for 30 s [95].…”

Section: Assays Employed In Mn Analysismentioning

confidence: 99%

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Dissolving Microneedles Developed in Association with Nanosystems: A Scoping Review on the Quality Parameters of These Emerging Systems for Drug or Protein Transdermal Delivery

2021

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The largest organ of the body provides the main challenge for the transdermal delivery of lipophilic or high molecular weight drugs. To cross the main barrier of the skin, the stratum corneum, many techniques have been developed and improved. In the last 20 years, the association of microneedles with nanostructured systems has gained prominence for its versatility and for enabling targeted drug delivery. Currently, the combination of these mechanisms is pointed to as an emerging technology; however, some gaps need to be answered to transcend the development of these devices from the laboratory scale to the pharmaceutical market. It is known that the lack of regulatory guidelines for quality control is a hindrance to market conquest. In this context, this study undertakes a scoping review of original papers concerning methods applied to evaluate both the quality and drug/protein delivery of dissolving and hydrogel-forming microneedles developed in association with nanostructured systems.

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Section: Mechanical Properties In Vitro Assaysmentioning

confidence: 99%

Section: Mechanical Properties In Vitro Assaysmentioning

confidence: 99%

Section: Mechanical Properties In Vitro Assaysmentioning

confidence: 99%

Section: Assays Employed In Mn Analysismentioning

confidence: 99%

See 2 more Smart Citations

Dissolving Microneedles Developed in Association with Nanosystems: A Scoping Review on the Quality Parameters of These Emerging Systems for Drug or Protein Transdermal Delivery

2021

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“…Due to the toxic effects presented by organic solvents, ethanol and dimethyl sulfoxide (DMSO) [ 18 , 19 ], a variety of nanostructured systems for controlled release have been developed to improve the bioavailability, solubility and therapeutic efficacy of CUR [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Nanosystems have been developed to circumvent CUR solubility, such as polymeric nanoparticles, inorganic nanoparticles and liposomes; however, micelles have several advantages such as the ability to incorporate lipo and water-soluble drugs, low cost and ease of large-scale production [ 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Micelles Dispersed in Ureasil-Polyether Materials for a Novel Sustained-Release Formulation

et al. 2021

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Vulvovaginal candidiasis (VVC) is a vulvar/vaginal infection that affects approximately 75% of women worldwide. The current treatment consists of antimicrobials with hepatotoxic properties and high drug interaction probabilities. Therefore, this study aimed to develop a new treatment to VVC based on micelles containing curcumin (CUR) dispersed in a ureasil-polyether (U-PEO) hybrid. The physical-chemical characterization was carried out in order to observe size, shape, crystallinity degree and particle dispersion in the formulation and was performed by dynamic light scattering (DLS), scanning electron microscopy (SEM), X-ray diffraction (XRD) and through in vitro release study. The results of DLS and SEM exhibited micelles with 35 nm, and encapsulation efficiency (EE) results demonstrated 100% of EE to CUR dispersed in the U-PEO, which was confirmed by the DRX. The release results showed that CUR loaded in U-PEO is 70% released after 10 days, which demonstrates the potential application of this material in different pharmaceutical forms (ovules and rings), and the possibility of multidose based on a single application, suggesting a higher rate of adherence.

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Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning

Jamaledin

Makvandi

Yiu

et al. 2020

Advanced Therapeutics

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Transdermal microneedle patches have attracted significant attention in the medical arena over the last decade as alternatives to traditional drug delivery methods. Microneedle patches are capable of delivering their payloads using burst-and sustained-release mechanisms, or in response to internal/external triggers, to optimize their therapeutic potency. Herein, drug release mechanisms and profiles are reviewed, along with the impact of the cargo release on cytotoxicity and delivery efficacy. The potential applications of microneedles in transdermal treatment, from prophylaxis to therapeutics, are also highlighted.

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Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin

Cited by 51 publications

References 38 publications

Dissolving Microneedles Developed in Association with Nanosystems: A Scoping Review on the Quality Parameters of These Emerging Systems for Drug or Protein Transdermal Delivery

Dissolving Microneedles Developed in Association with Nanosystems: A Scoping Review on the Quality Parameters of These Emerging Systems for Drug or Protein Transdermal Delivery

Curcumin-Loaded Micelles Dispersed in Ureasil-Polyether Materials for a Novel Sustained-Release Formulation

Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning

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