Preparation and Characterization of Dental Pit and Fissure Sealant Based on Calcium Sodium Silicate Bioactive Glasses

Abstract

This study aimed to prepare a resin based dental sealant loaded with novel bioactive glass formulated from (50 wt% calcium silicate and 50 wt% sodium silicate) with different percentages of fluorapatite. Four glass batches were formulated then characterized using Fourier Transform Infrared Spectroscopy analysis, X-ray powder diffraction analysis and Transmission electron microscopy. Density, microhardness and bioactivity testing after insertion in artificial saliva were done. Four bisphenol A-glycidyl methacrylate (Bis-GMA) based sealants loaded with the glass batch that showed the preeminent properties and silica fillers were prepared. The prepared sealants were compared to commercial sealants regarding flow, curing depth, compressive strength and microhardness. Sealant composition that showed comparable properties to that of the commercial sealant was selected for pH changes and ion release testing after immersion in artificial saliva for different time intervals. Results indicated amorphous nature, bioactive behavior and apatite forming ability of the tested glass batches. Experimental sealant revealed comparable tested properties with lower compressive strength compared to the commercial sealants at P < 0.001. The mean pH values of the tested sealants ranged from 6.75 to 6.35 with extended calcium and phosphorus ion release up to 90 days. It was concluded that the 85 wt% calcium silicate and sodium silicate with 15 wt% fluorapatite had the best trend regarding ion release and apatite forming ability. Sealant loaded with 65 wt% bioactive glass, 10 wt% sintered nanosilica and 10 wt% nanosilica had the best acceptable mechanical properties. The novel pit and fissure sealant is a promising bioactive and ion releasing material.

Evaluating the Translucency, Surface Roughness, and Cytotoxicity of a PMMA Acrylic Denture Base Reinforced with Bioactive Glasses

“…However, different conclusions were reached by Chen, et al [35], who studied the influence of osteoblast cell cultures (MC3T3) on cell line 58S glass (60% SiO 2 , 36% CaO, 4% P 2 O 5 ). In this case, the survival rate of cells in direct contact was 78% [35,36]. The bioactive material consisting of acrylic resin and containing 3% Novaron bioceramics, according to the authors of Chen, et al [35], is not cytotoxic.…”

Resin-based dental pulp capping restoration enclosing silica and portlandite nanoparticles from natural resources

“…Silane coupling agent was prepared by proportioning 70 wt.% ethanol in a glass beaker, a few drops of acetic acid were then added gradually into the solution to decrease the pH to 3–4. Finally 6 wt.% trimethoxysilane was added 11 , 35 . Stirring was done using a magnetic stirrer for 1 h. The silica nanoparticles synthesized from rice husk were incubated in the silane coupling agent for 2 h and then centrifuged (Megafuge 8R, Thermo Fisher, Germany) for 30 min.…”

“…Five cured cylindrical specimens with dimensions of 4 mm in diameter and 6 mm in height were prepared as previously mentioned. The specimens were then immersed in a freshly prepared artificial saliva (2.38 g Na 2 HPO 4 , 0.19 g KH 2 PO 4, and 8.00 g NaCl per liter of distilled water adjusted with phosphoric acid to pH 6.75) 35 and stored at 37 °C for 1, 7 and 14 days. The volume of the artificial saliva was adjusted to be 10 mm 3 according to the equation Vs = Sa/10, where Vs is the volume of the artificial saliva, and Sa is the apparent surface area of each specimen 41 .…”