Preparation and characterization of cyclodextrin nanosponges for organic toxic molecule removal

Varan, Cem; Anceschi, Anastasia; Sevli, Serhat; Bruni, Natascia; Giraudo, Leonardo; Bilgiç, Elif; Korkusuz, Petek; İskit, Alper B.; Trotta, Francesco; Bilensoy, Erem

doi:10.1016/j.ijpharm.2020.119485

Cited by 40 publications

(26 citation statements)

References 47 publications

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“…The MGN nanosponges were dispersed in double-distilled water for DLS analysis. A Malvern Zetasizer Nano ZS (Cambridge, UK) equipment was used to determine the zeta potential [66].…”

Section: Particle Size Estimationmentioning

confidence: 99%

Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies

et al. 2021

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Type 2 diabetes mellitus has been a major health issue with increasing morbidity and mortality due to macrovascular and microvascular complications. The urgent need for improved methods to control hyperglycemic complications reiterates the development of innovative preventive and therapeutic treatment strategies. In this perspective, xanthone compounds in the pericarp of the mangosteen fruit, especially α-mangostin (MGN), have been recognized to restore damaged pancreatic β-cells for optimal insulin release. Therefore, taking advantage of the robust use of nanotechnology for targeted drug delivery, we herein report the preparation of MGN loaded nanosponges for anti-diabetic therapeutic applications. The nanosponges were prepared by quasi-emulsion solvent evaporation method. Physico-chemical characterization of formulated nanosponges with satisfactory outcomes was performed with Fourier transform infra-red (FTIR) spectroscopy, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). Zeta potential, hydrodynamic diameter, entrapment efficiency, drug release properties, and stability studies at stress conditions were also tested. Molecular docking analysis revealed significant interactions of α-glucosidase and MGN in a protein-ligand complex. The maximum inhibition by nanosponges against α-glucosidase was observed to be 0.9352 ± 0.0856 µM, 3.11-fold higher than acarbose. In vivo studies were conducted on diabetic rats and plasma glucose levels were estimated by HPLC. Collectively, our findings suggest that MGN-loaded nanosponges may be beneficial in the treatment of diabetes since they prolong the antidiabetic response in plasma and improve patient compliance by slowly releasing MGN and requiring less frequent doses, respectively.

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“…The MGN nanosponges were dispersed in double-distilled water for DLS analysis. A Malvern Zetasizer Nano ZS (Cambridge, UK) equipment was used to determine the zeta potential [66].…”

Section: Particle Size Estimationmentioning

confidence: 99%

Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies

et al. 2021

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“…Moreover, a study on the use of CD-NSs for removing organic toxic molecules from the body was recently published [ 88 ]. Different nanosponges were tested for the ability to complex indole, a metabolite of tryptophan formed by the gut microbiota which can form dangerous uremic toxins, such as indoxyl sulfate, which is metabolized from indole in the liver.…”

Section: Applications Of Cyclodextrin-based Materials and Polymers In Food Sciencementioning

confidence: 99%

“…For future uses, the degradation of bonds of CD-based polymers should be considered. Natural cross-linkers (e.g., citric acid) might be used for food administration as they present a nontoxic profile [ 88 , 168 ]. However, the use of chemical cross-linkers such as epichlorohydrin has been studied.…”

Section: Critical Overview Of the Capacity Toxicity And Current Status Of Cd-based Materialsmentioning

confidence: 99%

Advances and Classification of Cyclodextrin-Based Polymers for Food-Related Issues

et al. 2021

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Cyclodextrins (CDs) are a good alternative to reduce or enhance different biomolecule characteristics and have demonstrated great results in food science. However, CDs present intrinsic limitations that can be solved by derivative synthesis. This review represents a survey of the state of the art of CD-based materials and their uses in food science. A deep review of the structure is carried out and different groups for ordination are suggested. After that, different applications such as cholesterol complexation or its use as sensors are reviewed. The derivatives show novel and promising activities for the industry. A critical perspective of the materials suggests that they might not present toxicity, although more studies are required. These points suggest that the research in this field will be increased in the following years.

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“…Moreover, a study about cyclodextrin nanosponges for removing organic toxic molecule from the body was recently published [ 132 ]. Cyclodextrin-based nanosponges are cross-linked polymer structures with a three-dimensional network tunable particle size and good swelling properties [ 14 ].…”

Section: Cyclodextrins As Active Drugsmentioning

confidence: 99%

“…In addition, this derivative was more stable in gastrointestinal media. Animal studies further revealed that orally administered CD-NSs do not tend to accumulate and damage gastrointestinal tissues and are excreted from the GI tract with minimal absorption [ 132 ].…”

Section: Cyclodextrins As Active Drugsmentioning

confidence: 99%

Cyclic Oligosaccharides as Active Drugs, an Updated Review

et al. 2020

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There have been many reviews of the cyclic oligosaccharide cyclodextrin (CD) and CD-based materials used for drug delivery, but the capacity of CDs to complex different agents and their own intrinsic properties suggest they might also be considered for use as active drugs, not only as carriers. The aim of this review is to summarize the direct use of CDs as drugs, without using its complexing potential with other substances. The direct application of another oligosaccharide called cyclic nigerosyl-1,6-nigerose (CNN) is also described. The review is divided into lipid-related diseases, aggregation diseases, antiviral and antiparasitic activities, anti-anesthetic agent, function in diet, removal of organic toxins, CDs and collagen, cell differentiation, and finally, their use in contact lenses in which no drug other than CDs are involved. In the case of CNN, its application as a dietary supplement and immunological modulator is explained. Finally, a critical structure–activity explanation is provided.

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Preparation and characterization of cyclodextrin nanosponges for organic toxic molecule removal

Cited by 40 publications

References 47 publications

Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies

Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies

Advances and Classification of Cyclodextrin-Based Polymers for Food-Related Issues

Cyclic Oligosaccharides as Active Drugs, an Updated Review

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