Preparation and characterization of colloidal particles synergistic with emulsifier stabilizing Pickering emulsion

Zhang, Yali; Xu, Xiaoqing; Wang, Qiang; Zhang, Hong; Qian, Airui; Tian, Liu; Xia, Qiang

doi:10.1080/10584587.2017.1336420

Cited by 7 publications

(2 citation statements)

References 7 publications

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“…For example, chitosan and alginate nanocapsules were prepared by the solvent displacement technique to improve its solubility of curcumin [12]. The resveratrol loaded zein/chitosan colloidal particles prepared by the classical antisolvent procedure had a higher stability and bioavailability [13]. Previous studies on UA-loaded chitosan focused on organic, acid-modified chitosan nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Drying Methods on the Characterization, Dissolution Rate and Antioxidant Activity of Ursolic Acid-Loaded Chitosan Nanoparticles

Zhao

Duan

Cao

et al. 2021

Foods

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To improve the water solubility of ursolic acid (UA), UA-loaded chitosan nanoparticles were firstly prepared by the ionotropic gelation method and dried by freeze drying (FD), microwave freeze drying (MFD) and spray drying (SD). The characterization of UA-loaded chitosan nanoparticles was performed with particle size, drug loading (DL), scanning electron microscope (SEM), fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), dissolution studies and antioxidant activity. The results demonstrated that UA was successfully encapsulated into chitosan nanoparticles using sodium tripolyphosphate (TPP) as a cross-linker, with a 79% encapsulation efficiency. The spray-dried, UA-loaded chitosan nanoparticles had the lowest drug loading (11.8%) and the highest particle size (496.9 ± 11.20 nm). The particle size of UA-loaded chitosan nanoparticles dried by MFD and FD was lower, at 240.8 ± 12.10 nm and 184.4 ± 10.62 nm, respectively, and their antioxidant activity was higher than those nanoparticles dried by SD. Moreover, the drying time and energy consumption of UA-loaded chitosan nanoparticles dried by MFD and SD were lower than that of FD. The dissolution rates of UA-loaded chitosan nanoparticles prepared by FD and MFD were 60.6% and 57.1%, respectively, in a simulated gastric fluid, which was a greater value than SD (55.9%). Therefore, the UA-loaded chitosan nanoparticles encapsulation method, combined with MFD technology, showed a promising potential to improve the water solubility of UA.

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Section: Introductionmentioning

confidence: 99%

Effects of Different Drying Methods on the Characterization, Dissolution Rate and Antioxidant Activity of Ursolic Acid-Loaded Chitosan Nanoparticles

Zhao

Duan

Cao

et al. 2021

Foods

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“…Matos et al [21] developed resveratrol-loaded Pickering emulsions stabilized by modified quinoa starch particles. Also, Zhang et al [22] encapsulated resveratrol in Pickering emulsions stabilized by zein/chitosan particles, proving higher stability and better sustained release of resveratrol in comparison with nanoemulsions developed in the same study. These resveratrol-loaded Pickering systems focused only on food applications, and no studies to date examined resveratrol entrapment in Pickering emulsions for skin applications.…”

Section: Introductionmentioning

confidence: 88%

Enhancing trans-resveratrol topical delivery and photostability through entrapment in chitosan/gum Arabic Pickering emulsions

Sharkawy

Casimiro

Barreiro

et al. 2020

International Journal of Biological Macromolecules

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The surfactant-free nature and higher stability of Pickering emulsions make them preferable solutions over conventional emulsions for skin applications. In this work, Pickering emulsions stabilized by chitosan/gum Arabic (CH/GA) nanoparticles were tested as vehicles for trans-resveratrol topical delivery. Skin absorption was examined ex vivo using Franz diffusion cells and porcine skin. Pickering emulsions allowed higher cutaneous retention and lower permeation of resveratrol, in comparison with a control solution based on a 20% v/v ethanol. The total amount of resveratrol retained in the skin, 24 h after the application, was 11.60% and 10.82% of the applied dose for the tested Pickering emulsion-based formulations prepared with 0.5% and 1.5% w/v CH/GA nanoparticles, respectively. In contrast, resveratrol skin retention from the control solution was only 2.86%. Confocal laser scanning microscopy revealed enhanced skin deposition of Nile Red to deeper layers from the Pickering emulsionbased formulations. Moreover, Pickering emulsions led to trans-resveratrol photostability increase, as measured after exposure to UV for 4 h. These results show that the CH/GA Pickering emulsions are promising solutions for the topical delivery of trans-resveratrol and have the potential to be used as green cosmetic products.

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Chitosan-based Pickering emulsions and their applications: A review

Sharkawy

Barreiro

Rodrigues

2020

Carbohydrate Polymers

159

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Preparation and characterization of colloidal particles synergistic with emulsifier stabilizing Pickering emulsion

Cited by 7 publications

References 7 publications

Effects of Different Drying Methods on the Characterization, Dissolution Rate and Antioxidant Activity of Ursolic Acid-Loaded Chitosan Nanoparticles

Effects of Different Drying Methods on the Characterization, Dissolution Rate and Antioxidant Activity of Ursolic Acid-Loaded Chitosan Nanoparticles

Enhancing trans-resveratrol topical delivery and photostability through entrapment in chitosan/gum Arabic Pickering emulsions

Chitosan-based Pickering emulsions and their applications: A review

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