Preparation and characterization of cobalt ferrite nanoparticles coated with fucan and oleic acid

Andrade, Priscyla Lima de; Silva, V. A. J.; Maciel, J. C.; Santillan, M. Mejía; Moreno, N. O.; Valladares, L. De Los Santos; Bustamante, Ángel; Pereira, Sônia Maria Barreto; Silva, M. P. C.; Aguiar, J. Albino

doi:10.1007/978-94-007-6482-8_25

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Inorganic nanoparticles (NPs), including metal oxides, act as great promising materials for applications in medicine fields, i.e., drug/gene delivery, biosensing, cell imaging, and cancer therapy. − Among the various types of metal oxide NPs, zinc oxide (ZnO) NPs have gained much research attention due to their low cost, high effectiveness, being easy to fabricate, and applications in diverse fields such as electronics, paints, clothing, sunscreen lotions, and cosmetic products. − As the production of ZnO NPs is continuously growing, there is current interest in their utilization in biological research fields like biosensing, nanomedicine, and cancer therapy. , It has been demonstrated that ZnO NPs are able to generate cytotoxicity in mammalian cells. , …”

Section: Introductionmentioning

confidence: 99%

One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach

Kanth Kadiyala,

Mandal,

Kumar Reddy

et al. 2023

ACS Omega

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This study focuses on a one-pot solvothermal synthetic route for the preparation of uniformly decorated zinc oxide nanoparticles on the surface of reduced graphene oxide (rGO/ZnO-NC) by using Andrographis paniculata leaf aqueous extract as an eco-friendly reducing agent. After characterizing the samples by different physical and chemical techniques, the anticancer activity of the synthesized rGO/ZnO-NC was examined on two human cancerous cell lines (HCT116 and A549) and one normal cell line (hMSCs). The MTT assays revealed that rGO/ZnO-NC exhibited dose-dependent cytotoxicity at a maximum concentration range of 10 ppm and the viability of the cells was drastically decreased to 95–96%. Measurement of reactive oxygen species (ROS) generation and Annexin V-FTIC staining assay revealed that rGO/ZnO-NC induced apoptosis in HCT116 and A549 cell lines. Thus, this study shows that the green-synthesized rGO/ZnO-NC has great potential in developing an efficacious novel therapeutic agent for cancers.

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Section: Introductionmentioning

confidence: 99%

One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach

Kanth Kadiyala,

Mandal,

Kumar Reddy

et al. 2023

ACS Omega

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Synthesis and Magnetic Properties of L‐Alanine Capped CoFe₂O₄ Nanoparticles

et al. 2018

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Here we report a low cost scalable synthesis of L‐alanine capped CoFe2O4 magnetic nanoparticles, with excellent size tunability and magnetic properties. Samples were analyzed in details using electron microscopy, X‐ray powder diffraction and vibrational sample magnetometry. The magnetic nanoparticles have demonstrated excellent size distribution, uniformity and phase purity. It was found that the presence and concentration of L‐alanine ligand dramatically affects the size and morphology of the resulting CoFe2O4 nanoparticles, enabling size tunability from 120.5 to 11.3 nm. The magnetic moments of nanomaterials are ranging from 74 to 41 Am2kg−1, they are easily manipulated by an external magnetic field and show the onset of superparamagnetic behavior in the smaller nanoparticles prepared.

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In Vivo Toxicity Studies of Chitosan-Coated Cobalt Ferrite Nanocomplex for Its Application as MRI Contrast Dye

Shakil

Hasan

Uddin

et al. 2020

ACS Appl. Bio Mater.

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Cobalt ferrite nanoparticle (CFN) has received attention in magnetic resonance imaging (MRI) as a promising contrast agent due to its higher saturation magnetization and magneto-crystalline anisotropy. However, the in vitro cytotoxicity of CFN has raised concern for its biomedical application as a diagnostic agent. The coating of CFN by a biocompatible polymer such as chitosan (CH) might lessen the biocompatibility concern. Therefore, in this study, we examined the applicability of chitosan-coated cobalt ferrite nanoparticle (CCN) as an MRI contrast dye and investigated its biocompatibility in vivo. Phantom MRI images revealed that the relaxivity of CCN was 121 (±8) mM–1s–1, indicating the potential of CCN as a T 2-weighted contrast agent. A single intravenous (iv) administration of CCN (10 mg/kg) improved the contrast of magnetic-resonance-imaging-based angiography (MRA) and brain-MRI in male albino Wistar rats compared to the control. Furthermore, toxicity studies dependent on dose (1–20 mg/kg) and time (1–28 days) in male albino Wistar rats confirmed the in vivo biocompatibility of CCN. The physical, hematological, biochemical, and histopathological observation assured that a single iv injection of CCN up to 20 mg/kg was well adjusted with liver, kidney, heart, and brain functions. The findings of the current study consolidate CCN as a promising candidate for MRI contrast dye.

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Preparation and characterization of cobalt ferrite nanoparticles coated with fucan and oleic acid

Cited by 3 publications

References 15 publications

One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach

One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach

Synthesis and Magnetic Properties of L‐Alanine Capped CoFe₂O₄ Nanoparticles

In Vivo Toxicity Studies of Chitosan-Coated Cobalt Ferrite Nanocomplex for Its Application as MRI Contrast Dye

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Preparation and characterization of cobalt ferrite nanoparticles coated with fucan and oleic acid

Cited by 3 publications

References 15 publications

One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach

One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach

Synthesis and Magnetic Properties of L‐Alanine Capped CoFe2O4 Nanoparticles

In Vivo Toxicity Studies of Chitosan-Coated Cobalt Ferrite Nanocomplex for Its Application as MRI Contrast Dye

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Synthesis and Magnetic Properties of L‐Alanine Capped CoFe₂O₄ Nanoparticles