Preparation and Characterization of Chitosan/LDH Composite Membranes for Drug Delivery Application

Radu, Elena; Pandele, Andreea Mădălina; Tuncel, Cristina; Miculescu, Florin; Voicu, Ştefan Ioan

doi:10.3390/membranes13020179

Cited by 9 publications

(3 citation statements)

References 79 publications

(90 reference statements)

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“…The membranes based on chitosan have been frequently used to carry out membrane processes for the separation of ions and molecules [ 57 , 58 , 59 , 60 ], but in this work, chitosan membranes are obtained on a polypropylene hollow fiber (C–PHF–M) support. Practically, the polypropylene hollow fiber (PHF) support, which has previously presented ultrafiltration performances [ 44 , 45 , 46 ], is transformed in nanofiltration composite membranes (C–PHF–M) by ultrafiltration of a chitosan solution to obtain in situ a selective layer of chitosan.…”

Section: Resultsmentioning

confidence: 99%

Simultaneously Recovery of Thorium and Tungsten through Hybrid Electrolysis–Nanofiltration Processes

Man,

Albu,

Nechifor

et al. 2024

Toxics

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The recovery and recycling of metals that generate toxic ions in the environment is of particular importance, especially when these are tungsten and, in particular, thorium. The radioactive element thorium has unexpectedly accessible domestic applications (filaments of light bulbs and electronic tubes, welding electrodes, and working alloys containing aluminum and magnesium), which lead to its appearance in electrical and electronic waste from municipal waste management platforms. The current paper proposes the simultaneous recovery of waste containing tungsten and thorium from welding electrodes. Simultaneous recovery is achieved by applying a hybrid membrane electrolysis technology coupled with nanofiltration. An electrolysis cell with sulphonated polyether–ether–ketone membranes (sPEEK) and a nanofiltration module with chitosan–polypropylene membranes (C–PHF–M) are used to carry out the hybrid process. The analysis of welding electrodes led to a composition of W (tungsten) 89.4%; Th 7.1%; O2 2.5%; and Al 1.1%. Thus, the parameters of the electrolysis process were chosen according to the speciation of the three metals suggested by the superimposed Pourbaix diagrams. At a constant potential of 20.0 V and an electrolysis current of 1.0 A, the pH is varied and the possible composition of the solution in the anodic workspace is analyzed. Favorable conditions for both electrolysis and nanofiltration were obtained at pH from 6 to 9, when the soluble tungstate ion, the aluminum hydroxide, and solid thorium dioxide were formed. Through the first nanofiltration, the tungstate ion is obtained in the permeate, and thorium dioxide and aluminum hydroxide in the concentrate. By adding a pH 13 solution over the two precipitates, the aluminum is solubilized as sodium aluminate, which will be found after the second nanofiltration in the permeate, with the thorium dioxide remaining integrally (within an error of ±0.1 ppm) on the C–PHF–M membrane.

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Section: Resultsmentioning

confidence: 99%

Simultaneously Recovery of Thorium and Tungsten through Hybrid Electrolysis–Nanofiltration Processes

Man,

Albu,

Nechifor

et al. 2024

Toxics

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show abstract

“…Significant attention is directed towards its potential medical and pharmaceutical applications due to its remarkable properties, such as biocompatibility, biodegradability, and non-toxicity, which make it very valuable in the biomedical field [ 84 , 92 ]. Chitosan is a biocompatible substance that does not trigger an immune response, making it compatible with living tissues.…”

Section: Chitosan Properties and Hemostasis Efficiencymentioning

confidence: 99%

Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances

Gheorghiță,

Moldovan,

Robu

et al. 2023

IJMS

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Hemorrhage is a detrimental event present in traumatic injury, surgery, and disorders of bleeding that can become life-threatening if not properly managed. Moreover, uncontrolled bleeding can complicate surgical interventions, altering the outcome of surgical procedures. Therefore, to reduce the risk of complications and decrease the risk of morbidity and mortality associated with hemorrhage, it is necessary to use an effective hemostatic agent that ensures the immediate control of bleeding. In recent years, there have been increasingly rapid advances in developing a novel generation of biomaterials with hemostatic properties. Nowadays, a wide array of topical hemostatic agents is available, including chitosan-based biomaterials that have shown outstanding properties such as antibacterial, antifungal, hemostatic, and analgesic activity in addition to their biocompatibility, biodegradability, and wound-healing effects. This review provides an analysis of chitosan-based hemostatic biomaterials and discusses the progress made in their performance, mechanism of action, efficacy, cost, and safety in recent years.

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“…The membranes based on chitosan have been frequently used to carry out membrane processes for the separation of ions and molecules [57][58][59][60], but in this work, chitosan membranes are obtained on a polypropylene hollow fiber (C-PHF-M) support. Practically, the polypropylene hollow fiber (PHF) support, which has previously presented ultrafiltration performances [44][45][46], is transformed in nanofiltration composite membranes (C-PHF-M) by ultrafiltration of a chitosan solution to obtain in situ a selective layer of chitosan.…”

Section: Characterization Of C-phf-m Membranementioning

confidence: 99%

Simultaneously Recovery of Thorium and Tungsten by Hybrid Electrolysis–Nanofiltration Processes

Man,

Albu,

Nechifor

et al. 2023

Preprint

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The recovery and recycling of metals that generate toxic ions in the environment is of particular importance, especially when these are tungsten and, in particular, thorium. The radioactive element thorium has unexpectedly accessible domestic applications (filaments of light bulbs and electronic tubes, welding electrodes, working alloys containing aluminum and magnesium), which lead to its appearance in electrical and electronic waste from municipal waste management platforms. The current paper proposes the simultaneous recovery of waste containing tungsten and thorium from welding electrodes. The simultaneous recovery is done by applying a hybrid membrane electrolysis technology coupled with nanofiltration. An electrolysis cell with sulphonated polyether–ether–ketone membranes (sPEEK) and a nanofiltration module with chitosan-polypropylene membranes (C–PHF–M) are used to carry out the hybrid process. The analysis of welding electrodes led to a composition of: W (tungsten) 89.4%; Th 7.1%; O2 2.5% and Al 1.1%. Thus, the parameters of the electrolysis process were chosen according to the speciation of the three metals suggested by the superimposed Pourbaix diagrams. At a constant potential of 20.0 V and an electrolysis current of 1.0 A, the pH is varied and the possible composition of the solution in the anodic workspace is analyzed. Favorable conditions for both electrolysis and nanofiltration were obtained at pH from 6 to 9, when the soluble tungstate ion, the aluminum hydroxide and solid thorium dioxide were formed. Through a first nanofiltration, the tungstate ion is obtained in the permeate, and thorium dioxide and aluminum hydroxide in the concentrate. By adding a pH 13 solution over the two precipitates, the aluminum is solubilized as sodium aluminate which will be found after the second nanofiltration in permeate, the thorium dioxide remaining integrally (within an error of ±0.1ppm) on the C–PHF–M membrane.

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Preparation and Characterization of Chitosan/LDH Composite Membranes for Drug Delivery Application

Cited by 9 publications

References 79 publications

Simultaneously Recovery of Thorium and Tungsten through Hybrid Electrolysis–Nanofiltration Processes

Simultaneously Recovery of Thorium and Tungsten through Hybrid Electrolysis–Nanofiltration Processes

Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances

Simultaneously Recovery of Thorium and Tungsten by Hybrid Electrolysis–Nanofiltration Processes

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