Preparation and characterization of chitosan-g-poly(vinyl alcohol)/poly(vinyl alcohol) blends used for the evaluation of blood-contacting compatibility

Don, Trong‐Ming; King, Chia-Fong; Chiu, Wen‐Yen; Peng, Ching‐An

doi:10.1016/j.carbpol.2005.08.023

Cited by 95 publications

(39 citation statements)

References 38 publications

(51 reference statements)

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“…Furthermore, the composition of chitosan and PVA in the obtained CS-g-PVA/PVA product could be estimated to be 13.3% and 86.7%, respectively. e Fourier transform infrared spectroscopy (FTIR) was used to characterize the functional groups of CS-g-PVA/PVA product and the results were consistent with Don et al [14].…”

Section: Characterization Of Cs-g-pva/supporting

confidence: 72%

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An Investigation of Chitosan‐Grafted‐Poly(vinyl alcohol) as an Electrolyte Membrane

Danwanichakul

Sirikhajornnam²

2012

Journal of Chemistry

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The membrane of chitosan-grafted-poly(vinyl alcohol)/poly(vinyl alcohol) (CS-g-PVA/PVA) was investigated along with chitosan (CS), PVA, CS/PVA, and Nafion 117 membranes for transport properties of water and methanol, mechanical properties, and ionic conductivity. The ionic conductivity,σ, of the crosslinked CS-g-PVA/PVA membrane was about 4.37 mS cm−1and the methanol permeability,PS, was1.8×10−7 cm2s−1. These gave the selectivity,σ/PS, of 23.95 mS·s·cm−3compared with 16.35 mS·s·cm−3of Nafion 117 membrane. The conductivity of the crosslinked CS-g-PVA/PVA membrane was greater than others including Nafion 117 when the membranes were saturated with methanol solution of which concentration was greater than 20%. This fact and that the mechanical properties of the wet crosslinked CS-g-PVA/PVA membrane were comparable to those of other membranes made it a promising material to be used as an electrolyte membrane in a direct methanol fuel cell.

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Section: Characterization Of Cs-g-pva/supporting

confidence: 72%

“…e synthesis follows the method proposed by Don et al [14], which is a two-step reaction. Brie�y, in the �rst step, 15 g of chitosan �akes were dissolved in 2 wt% acetic acid solution.…”

Section: Synthesis Of Chitosan-graed-poly(vinyl Alcohol)/poly (Vinylmentioning

confidence: 99%

An Investigation of Chitosan‐Grafted‐Poly(vinyl alcohol) as an Electrolyte Membrane

Danwanichakul

Sirikhajornnam²

2012

Journal of Chemistry

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“…The peak observed at around 2947 cm −1 is due to the typical C−H stretch vibrations. 48 In Figure 6A, all major peaks related to hydroxyl and acetate groups are shown in the FTIR spectrum of PVA. More specifically, the broad band observed between 3550 and 3200 cm −1 is associated with the O−H stretch from the intermolecular and intramolecular hydrogen bonds.…”

Section: Morphology and Porosity Of Nanofibrous Scaffoldsmentioning

confidence: 99%

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

Alhosseini¹,

Moztarzadeh²,

Mozafari³

et al. 2012

IJN

122

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Among several attempts to integrate tissue engineering concepts into strategies to repair different parts of the human body, neuronal repair stands as a challenging area due to the complexity of the structure and function of the nervous system and the low efficiency of conventional repair approaches. Herein, electrospun polyvinyl alcohol (PVA)/chitosan nano-fibrous scaffolds have been synthesized with large pore sizes as potential matrices for nervous tissue engineering and repair. PVA fibers were modified through blending with chitosan and porosity of scaffolds was measured at various levels of their depth through an image analysis method. In addition, the structural, physicochemical, biodegradability, and swelling of the chitosan nanofibrous scaffolds were evaluated. The chitosan-containing scaffolds were used for in vitro cell culture in contact with PC12 nerve cells, and they were found to exhibit the most balanced properties to meet the basic required specifications for nerve cells. It could be concluded that addition of chitosan to the PVA scaffolds enhances viability and proliferation of nerve cells, which increases the biocompatibility of the scaffolds. In fact, addition of a small percentage of chitosan to the PVA scaffolds proved to be a promising approach for synthesis of a neural-friendly polymeric blend.

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“…4,23,28 A good blood-contact property was observed for pure PVA. 29 Moreover, bovine serum albumin (BSA) tends to adsorb to hydrophobic surfaces more than hydrophilic ones. 30 PVA has good blood compatibility.…”

Section: Introductionmentioning

confidence: 99%

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Jannesari¹,

Varshosaz²,

Morshed³

et al. 2011

IJN

138

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The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the first time. The morphology and average diameter of the electrospun nanofibers were investigated by scanning electron microscopy. X-ray diffraction studies indicated an amorphous distribution of the drug inside the nanofiber blend. Introducing the drug into polymeric solutions significantly decreased solution viscosities as well as nanofiber diameter. In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release. Blending PVA and PVAc exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications. Also, the thickness of the blend nanofiber mats strongly influenced the initial release and rate of drug release.

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Preparation and characterization of chitosan-g-poly(vinyl alcohol)/poly(vinyl alcohol) blends used for the evaluation of blood-contacting compatibility

Cited by 95 publications

References 38 publications

An Investigation of Chitosan‐Grafted‐Poly(vinyl alcohol) as an Electrolyte Membrane

An Investigation of Chitosan‐Grafted‐Poly(vinyl alcohol) as an Electrolyte Membrane

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

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