Preparation and characterization of Ceftazidime loaded electrospun silk fibroin/gelatin mat for wound dressing

Safdari, Masumeh; Shakiba, Ebrahim; Kiaie, Seyed Hossein; Fattahi, Ali

doi:10.1007/s12221-016-5822-3

Cited by 57 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SF films exhibited a slower doxorubicin release with smaller nanostructure and more β-sheet structure content [58]. Ceftazidime (CTZ) was successfully encapsulated into SF/gelatin mats and showed antibacterial effects during a release process of over six hours [71]. Recently, film structured SF biomaterials have also been used in guiding bone regeneration.…”

Section: Structure Design Of Silk Fibroin-based Biomaterialsmentioning

confidence: 99%

A Review of Structure Construction of Silk Fibroin Biomaterials from Single Structures to Multi-Level Structures

Wang

Wei

et al. 2017

IJMS

363

241

View full text Add to dashboard Cite

The biological performance of artificial biomaterials is closely related to their structure characteristics. Cell adhesion, migration, proliferation, and differentiation are all strongly affected by the different scale structures of biomaterials. Silk fibroin (SF), extracted mainly from silkworms, has become a popular biomaterial due to its excellent biocompatibility, exceptional mechanical properties, tunable degradation, ease of processing, and sufficient supply. As a material with excellent processability, SF can be processed into various forms with different structures, including particulate, fiber, film, and three-dimensional (3D) porous scaffolds. This review discusses and summarizes the various constructions of SF-based materials, from single structures to multi-level structures, and their applications. In combination with single structures, new techniques for creating special multi-level structures of SF-based materials, such as micropatterning and 3D-printing, are also briefly addressed.

show abstract

Section: Structure Design Of Silk Fibroin-based Biomaterialsmentioning

confidence: 99%

A Review of Structure Construction of Silk Fibroin Biomaterials from Single Structures to Multi-Level Structures

Wang

Wei

et al. 2017

IJMS

363

241

View full text Add to dashboard Cite

show abstract

“…The drug was released from the nanofibers for 6 h, and the formation of the zone of inhibition in the diffusion test demonstrated the antibacterial effect of the drug-loaded nanofibers. Together, the fibroin/GEL/ceftazidime nanofibrous system can enhance drug effectiveness particularly in the prevention of postsurgical adhesions and wound dressing infections [15].…”

Section: Gelatin Electrospun Scaffoldsmentioning

confidence: 99%

Gelatin and Collagen Nanofiber Scaffolds for Tissue Engineering

Monroy¹,

Bravo²,

Mercado³

et al. 2018

Tissue Regeneration

View full text Add to dashboard Cite

One of the main complications that can present a person with second and third degree burns is the possibility of being infected by opportunistic bacteria or viruses that are present in the environment. Nowadays, the majority of the burn injuries are treated with conventional gauze, which involves a high probability of infection and pain for the patient being treated with this method. In order to obtain low-cost scaffolds, natural and abundant polymers were used such as gelatin (GEL) and collagen (COL). The GEL functions as a base scaffold, stable and flexible, and also biocompatible because it is a byproduct of the partial hydrolysis of COL, which is an indispensable component for the stability of the cell membrane and it is present in great extent in the human epithelium.

show abstract

“…Regarding the weakened thermoregulation function of damaged skin, an ideal wound healing material should also protect the wound from the environmental temperature changes, otherwise a low temperature will lead to reduced blood circulation and oxygen supply of tissues due to the contraction of capillaries, and a high temperature will increase the oxygen demand for tissue metabolism and aggravate the hypoxia of the damaged skin . Therefore, new wound dressings need to possess heat management properties.…”

Section: Introductionmentioning

confidence: 99%

Preparation of regenerated silk fibroin‐based heat‐management sponge for wound healing

Liu

Zhao

Wang

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

In the present study, a regenerated silk fibroin (RSF) sponge incorporated with the phase change microcapsules were synthesized by facile and effective routes. The microcapsules with the phase change materials (PCMs) core and the RSF wall were prepared by simple coacervation. By altering the synthesis parameters including the emulsifier concentration and the RSF concentration, the microcapsules exhibiting optimized spherical geometry, high encapsulation efficiency, high phase change enthalpies, good thermal cycling performance, and high thermal stability were synthesized. As to the preparation of the microstructurally aligned RSF sponge, a new type of freeze–thaw method was used for the first time, the resultant sponge exhibited high elastic resilience. Subsequently, the combination of microcapsules with the RSF sponge was achieved by a convenient deposition method with the aid of ultrasonic agitation, which showed well maintained porous structure and satisfactory phase change enthalpies of 23.16 and 23.32 J•g−1 corresponding to the heating and cooling process, respectively. Therefore, the PCMs‐incorporated RSF sponge exhibited the capacity to regulate the temperature in order to create a stable “microclimate.” Regarding the exceptional biocompatibility, biodegradability, and super comfort of RSF materials, the RSF‐based sponge can be an ideal candidate for wound dressing applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48173.

show abstract

Preparation and characterization of Ceftazidime loaded electrospun silk fibroin/gelatin mat for wound dressing

Cited by 57 publications

References 25 publications

A Review of Structure Construction of Silk Fibroin Biomaterials from Single Structures to Multi-Level Structures

A Review of Structure Construction of Silk Fibroin Biomaterials from Single Structures to Multi-Level Structures

Gelatin and Collagen Nanofiber Scaffolds for Tissue Engineering

Preparation of regenerated silk fibroin‐based heat‐management sponge for wound healing

Contact Info

Product

Resources

About