Preparation and characterization of carboxymethylated carrageenan modified with collagen peptides

Fan, Lihong; Tong, Jun; Chang, Tang; Wu, Huan; Peng, Min; Yi, Jiayan

doi:10.1016/j.ijbiomac.2015.10.063

Cited by 22 publications

(12 citation statements)

References 27 publications

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“…CMKC is a great candidate for tissue engineering and osteogenic scaffolds due to its antibacterial activity and hemocompatibility. [ 38,41,62,63 ]…”

Section: Resultsmentioning

confidence: 99%

“…CMKC is a great candidate for tissue engineering and osteogenic scaffolds due to its antibacterial activity and hemocompatibility. [38,41,62,63] Mesenchymal stem cells are very useful for engineering a variety of tissues. Different types of stem cells can be used for these studies, however ADSCs can be obtained in large number and they are advantageous when compared to other stem cell types, due to their unique secretory factors and differentiation capacity.…”

Section: Osteogenic Differentiation Assaymentioning

confidence: 99%

“…Carboxymethylated KC (CMKC) has improved properties compared to KC, including lower solution viscosity, retention of humidity, antibacterial activity in solid media, and promotion of wound healing when combined with collagen peptides. [36][37][38] Our group studied CMKCs with different degrees of substitution, and we showed that CMKC has enhanced properties, such as nontoxicity for adipose derived stem cells, nonhemolytic activity for human red blood cells, radical scavenging activity and growth inhibition for Gram positive and Gram-negative bacteria, when compared to KC. [38] Based on these criteria, CMKC could be an excellent candidate material to be used as a substitute for KC in biomaterial fabrication for tissue engineering and regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible Crosslinked Nanofibers of Poly(Vinyl Alcohol)/Carboxymethyl‐Kappa‐Carrageenan Produced by a Green Process

Madruga

Balaban

Popat

et al. 2020

Macromolecular Bioscience

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This study presents a new type of biocompatible nanofiber based on poly(vinyl alcohol) (PVA) and carboxymethyl‐kappa‐carrageenan (CMKC) blends, produced with no generation of hazardous waste. The nanofibers are produced by electrospinning using PVA:CMKC blends with ratios of 1:0, 1:0.25, 1:0.4, 1:0.5, and 1:0.75 (w/w PVA:CMKC) in aqueous solution, followed by thermal crosslinking. The diameter of the fibers is in the nanometer scale and below 300 nm. Fourier transform infrared spectroscopy shows the presence of the carboxyl and sulfate groups in all the fibers with CMKC. The nanofibers from water‐soluble polymers are stabilized by thermal crosslinking. The incorporation of CMKC improves cytocompatibility, biodegradability, cell growth, and cell adhesion, compared to PVA nanofibers. Furthermore, the incorporation of CMKC modulates phenotype of human adipose‐derived stem cells (ADSCs). PVA/CMKC nanofibers enhance ADSC response to osteogenic differentiation signals and are therefore good candidates for application in tissue engineering to support stem cells.

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“…CMKC is a great candidate for tissue engineering and osteogenic scaffolds due to its antibacterial activity and hemocompatibility. [ 38,41,62,63 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Osteogenic Differentiation Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biocompatible Crosslinked Nanofibers of Poly(Vinyl Alcohol)/Carboxymethyl‐Kappa‐Carrageenan Produced by a Green Process

Madruga

Balaban

Popat

et al. 2020

Macromolecular Bioscience

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“…Carrageenans are widely used in the food industry due to their texturizing properties, highlighting their thickening and gelling capacity and their ability to stabilize proteins [8,9]; additionally, they also find applications in the pharmaceutical [10], cosmetic [11], printing and textile industries [12]. Of special interest is their use for the production of hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Understanding nanostructural differences in hydrogels from commercial carrageenans: Combined small angle X-ray scattering and rheological studies

et al. 2020

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Hydrogels from commercial carrageenans (κ-C, ι-C, λ↑-C (high viscosity) and λ↓-C (low viscosity)) were prepared with and without the addition of salts (KCl and CaCl 2 ). FT-IR and 1 H NMR characterization evidenced that while the κ-C and ι-C grades were relatively pure carrageenans, the two λ-C grades were λ-, κ-, θand μcarrageenan hybrids. The effect of carrageenan and salt concentration on the hydrogel strength were evaluated through a response surface design and a detailed structural characterization was carried out by small angle X-ray scattering (SAXS) and rheology. The low amount of sulphate substitution in κ-C enabled intramolecular association, giving rise to strong hydrogels, even in the absence of salts. On the other hand, ι-C, λ↑-C and λ↓-C produced much weaker hydrogels and required the addition of salts to induce intramolecular association by ionic cross-linking. SAXS results suggested the formation of similar structures of double helices in κ-C and ι-C with the addition of salts; however, distinct network structures were attained. In the case of κ-C, a Gauss-Lorentz gel model was suitable to describe the hydrogel structure and the addition of K + promoted the formation of more ordered and densely packed structures. On the other hand, larger but weaker aggregates, with marked periodicity, were observed in ι-C, with Ca 2+ inducing the formation of more densely packed networks. The complex composition of the λ-C grades gave rise to more heterogeneous branched network structures, properly described by a correlation length model, where the gelation mechanism was mostly governed by the κ-carrageenan component.

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“…Carboxymethyl groups improve the anticoagulant, antibacterial, moisture sorption, and moisture retention of 𝜅-carrageenan, that is, utilized in wound dressings. [111] Collagen peptides modified with carboxymethyl 𝜅-carrageenan demonstrated skin healing potential. The extent of substitution influences the linking capacity of carboxymethyl chitosancarrageenan.…”

Section: Carrageenan-based Hybrids With Chitosanmentioning

confidence: 99%

Carrageenan‐Based Hybrids with Biopolymers and Nano‐Structured Materials for Biomimetic Applications

et al. 2022

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Carrageenan is an algal‐originated group of polysaccharides with unusual structural and functional capabilities, desired for different biomimetic applications due to their renewable, biocompatible, and biodegradable nature. Carrageenan‐based hybrids (nano‐/biocomposites) with different biopolymers and nano‐structured materials have been widely reported as potential candidates for bone/cartilage tissue engineering, delivery of drugs/bioactive ingredients, wound healing, and 3D bioprinting applications. Owning to the broad‐scale biomimetic applications of carrageenan‐based materials, this review aims to summarize carrageenan chemistry and distinct physicochemical features of biopolymeric and/or nanostructured materials‐based on carrageenans in a detailed manner. Herein, different biopolymers (such as chitosan, cellulose, starch, and alginates), and nano‐structured materials (such as silica nanoparticles, magnetic/non‐magnetic nanocarriers, graphene oxide nanoparticles, carbon nanotubes/nanorods, metal oxide nanoparticles) are comprehensively described in combination with carrageenan. However, carrageenan toxicity studies have presented major challenges that need to be addressed when using carrageenan‐based materials for biomedical and therapeutic purposes. Several existing challenges, prospects, and research recommendations are described at the end of this review.

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Preparation and characterization of carboxymethylated carrageenan modified with collagen peptides

Cited by 22 publications

References 27 publications

Biocompatible Crosslinked Nanofibers of Poly(Vinyl Alcohol)/Carboxymethyl‐Kappa‐Carrageenan Produced by a Green Process

Biocompatible Crosslinked Nanofibers of Poly(Vinyl Alcohol)/Carboxymethyl‐Kappa‐Carrageenan Produced by a Green Process

Understanding nanostructural differences in hydrogels from commercial carrageenans: Combined small angle X-ray scattering and rheological studies

Carrageenan‐Based Hybrids with Biopolymers and Nano‐Structured Materials for Biomimetic Applications

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