Preparation and Characterization of Carbopol Based Hydrogels Containing Dexpanthenol

Abstract

Objective: The purpose of this study is to create dexpanthenol-loaded hydrogel formulations to alter the release patterns and enhance the physicochemical qualities of the market product. Material and Method: To make hydrogel formulations, Carbopol Ultrez was utilized in concentrations of 1%, 1.5%, and 2% (w/w). The active component dexpanthenol was then added to the formulations at a concentration of 5% (w/w). pH, viscosity, texture profile analysis, spreadability, bioadhesion, and in vitro release characteristics were all assessed for the formulations. Result and Discussion: The formulations were found to be suitable for cutaneous application. TPA analysis revealed that the G1 and G1-DXP formulations had the hardness value 10.1851.219 and 30.8541.637 g, respectively. That formulations’ bioadhesion strength has grown because they are more flexible than previous formulations while having low hardness values. As such, it has been observed that the formulations release more than 50% of DXP in three hours while the market preparation was not even reach the 10% drug release. In the in vitro release kinetics study, it was calculated that all formulations fit the Higuchi model. As a result, a more effective drug delivery system has been developed compared to the market preparation. The currently prepared formulations are also promising formulations in terms of their use in treatment.

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

“…Among the kinetic models applied to the release profiles, the highest r 2 was obtained with Higuchi kinetics (Table 3). Higuchi kinetics is the most suitable kinetic model to describe the release profile of semisolids [65][66][67]. It appeared that drug release is both diffusion-and erosion-controlled.…”

“…One g of gel was filled into a glass beaker. The probe was moved downwards, and the gel was contacted with the skin with 1 N of applied force for 120 s. At the end of the time, the probe moved upwards and separated from the gel [60,65]. While the highest force obtained when leaving the gel surface was recorded as the bioadhesive force, the distance at the detachment time and the bioadhesive force provided the work of adhesion to be obtained using the device software and the following Equation 1.…”