Preparation and Characterization of Calcium-Incorporated Rosa roxburghii Tratt and Its Efficacy on Bone Mineral Density in Rats

Abstract

The deficiency of traditional calcium preparation will gradually be replaced by the new type of calcium preparation. Rosa roxburghii fruit (R. roxburghii) is popular for its rich nutrients and functional ingredients. The fermentation broth of R. roxburghii, involving amino acids, flavonoids, triterpenes, polysaccharides, and other compounds, is favorable for calcium chelation. Thus, this study fabricated calcium-incorporated R. roxburghii (FECa) and further illustrated its efficacy on bone mineral density (BMD) in rats. The calcium holding capacity of FECa was identified and confirmed using AAS. Ion complexation of FECa was characterized using 1H-NMR, UV, SEM and EDS, and FTIR. The calcium contents of femurs were increased by 36%, and the bone trabeculae of femurs were significantly increased. Net calcium balance was enhanced to further improve BMD by oral administration of FECa. The above results indicate that FECa can be a potential and efficient calcium supplementation agent.

Combined Metabolite and Transcriptomic Profiling Unveil a Potential Gene Network Involved in the Triterpenoid Metabolism of Rose roxburghii

“…The region's food and pharmaceutical sectors greatly benefit from this species owing to the rich assortment of bioactive compounds found in its fruits, including vitamin C, amino acids, flavonoids, and terpenoids [1-3]. These compounds exhibit notable pharmacological effects, encompassing antibacterial, anti-aging, anti-apoptotic, antioxidant, and anti-atherosclerotic properties [4][5][6]. With advancing research, the potential health advantages of R. roxburghii have attracted widespread attention.Currently, Guangzhou Pharmaceutical Group Co., Ltd. has successfully developed various products from the fruit of R. roxburghii, including juice, vinegar, jam, and cakes, etc., which generate considerable economic benefits with sales exceeding RMB 100 million [6].…”