Preparation and characterization of BSA and chitosan nanopartices for sustainable delivery system for quercetin

Abstract

The current study was undertaken in order to evaluate the efficacy of BSA and chitosan nanoparticle for sustainable delivery of Quercetin. BSA and chitosan nanoparticles were prepared by coacervation process and Ionic gelation method respectively and were characterized by Scanning Electron Microscope. The average size of BSA and chitosan nanoparticles was found to be 96nm and 42.7nm respectively. Quercetin loaded BSA and chitosan nanoparticles were smooth and spherical with the average size of 317.1 nm and 44.1nm respectively. The encapsulation efficiency of the BSA and chitosan nanoparticles were calculated and it was found that the drug encapsulation efficiency was more in chitosan than in BSA. The in vitro analysis of Quercetin loaded BSA and chitosan nanoparticles were studied using dialysis bag. The nanoformulation of Quercetin loaded BSA nanoparticles shows a sustainable release of drug in which 56% of the drug was released till 24 hours and it did not change further. For Quercetin loaded chitosan nanoparticles it shows 72% of in vitro drug release for 24 hours and found to be better than BSA nanoparticle. Hence both Quercetin loaded BSA and chitosan nanoparticles were effective in encapsulation and sustainable release which also paves way for the bio availability of Quercetin

Comparison and Process Optimization of PLGA, Chitosan and Silica Nanoparticles for Potential Oral Vaccine Delivery

“…This is due to the interaction between crystalline TPP and chitosan, but with reduced crystallinity. The positions of the narrow intensity peaks was not shifted in the BSA loaded nanoparticles (compared to blank) but peak intensity reduced after BSA loading suggesting a certain degree of interaction between BSA and chitosan-TPP nanoparticles [30]. Hydrogen bonding is formed based on the nanoparticle complexes between the nitrogen atoms of BSA protein and H atoms from NH2, NH3 + and P=O groups of chitosan-TPP nanoparticles.…”

Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine

“…Being polycationic, chitosan can interact with negatively charged molecules and can form a core shell nanostructure that serves as an efficient drug delivery system [140]. As a drug carrier, chitosan has been reported to be capable of delivering drugs to various organs such as kidney, liver, lungs and colon [141]. A pH sensitive, chitosan-coated nanoparticle system to enhance the oral uptake of drugs via chitosan mediated tight junction opening has also been developed [142].…”

The Anti-Proliferative and Pro-Apoptotic Properties of Ethanol Plectranthus amboinicus (Lour.) Spreng. Leaves Ethanolic Extract Nanoparticles on T47D Cell Lines

“…Nanoparticles form is an ideal solution for the anti-cancer drugs with improved selectivity and reduced side-effects toward the tumor cells. Drug-loaded nanoparticles can be developed to perform more complex, cooperative targeting functions (Hasibuan et al, 2016;Raj et al, 2015).…”