Preparation and Characterization of Biologically Active Bismuth(III) Tropolonato Complexes

Abstract

Two new types of bismuth(III) tropolonato complexes, nitratobis(tropolonato)bismuth(III) (1d) and phenylbis(tropolonato)bismuthin (1f), are synthesized and characterized by elemental analysis, 1H‐NMR, 13C‐NMR, IR spectroscopy, and conductivity measurements. The structures of 1d and aquabis(4,5‐benzotropolonato)bismuth(III) nitrate (6b) are confirmed by X‐ray structural analyses. Derivatives of tropolone (2a) and their bismuth(III) complexes are synthesized and characterized in the same manner. Eight of these compounds are tested against Helicobacter pylori (H.p.) bacteria, which cause chronic gastritis and peptic ulcus. Most of the bismuth compounds show high in vitro activity against H.p.

Influence of pH and type of counterion on the formation of bismuth(III) complexes with tropolonato and 5-methyltropolonato ligands: Synthesis, structure, spectroscopic characterization and calculation studies

“…The IR spectra of tropolonato-metal(II) and -metal(III) complexes have been presented in detail [19,74]. Moreover, some efforts in describing the main bands for bismuth(III), gallium(III), and indium(III) compounds have been made previously [2,17].…”

“…There were compounds with the formula: [Bi(trop) 2 Cl] [15], Bi(trop) 3 and Na[Bi(trop) 4 ] [16]. In 1995 the preparation and characterization of new bismuth(III) compounds with tropolone and its derivatives have been presented but only the structures of nitratobis(tropolonato)bismuth(III) and aquabis(4,5-benzotropolonato)bismuth(III) nitrate have been shown [17]. However, these structures are not available in the Cambridge Structural Database.…”

“…Bismuth compounds have been extensively studied in the respect of their biological activity [17,[20][21][22][23][24][25][26][27][28]. In a large number of papers their antibacterial properties have been reported [17,20,21,[23][24][25][26][27].…”

“…In a large number of papers their antibacterial properties have been reported [17,20,21,[23][24][25][26][27]. Therefore bismuth compounds are applied in medicine, e.g.…”

Bismuth–dithiol inhibition of the Escherichia coli rho transcription termination factor

“…Most of these bismuth-dithiol mixtures and other bioactive bismuth agents have not been structurally characterized, in part, because of their low solubility in solvents [8]. Thus, only a few X-ray crystallographic and NMR structures of bioactive bismuth complexes have appeared [11,[28][29][30][31][32][33][34][35]. Relevant to our study are reports that bismuth centers can form complexes with three sulfur substituents or six substituents where three of the six substituents are sulfur and the other three are either nitrogen or oxygen [28][29][30][31][32].…”