Preparation and Characterization of Biodegradable Hydrogels for Tissue Expander Application

Yuk, Kun Young; Kim, Ye Tae; Im, Su Jin; Garner, John; Fu, You Rong; Park, Ki Nam; Park, Jeong Sook; Huh, Kang Moo

doi:10.7317/pk.2010.34.3.253

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously reported [31, 32], the swelling of the whole polymer matrix is temporarily retarded by the hydrophobic polyester regions, which results in a lag time before the expander starts swelling. Such a lag time is designed for the tissue to heal after surgical implantation of the hydrogel.…”

Section: Resultssupporting

confidence: 57%

See 1 more Smart Citation

Reshapable polymeric hydrogel for controlled soft-tissue expansion: In vitro and in vivo evaluation

Garner

Davidson

Eckert

et al. 2017

Journal of Controlled Release

Self Cite

View full text Add to dashboard Cite

Tissue expansion is the process by which extra skin is generated using a device that applies pressure from underneath the skin. Over the course of weeks to months, stretching by this pressure creates a flap of extra tissue that can be used to cover a defect area or enclose a permanent implant. Conventional tissue expanders require a silicone shell inflated either by external injections of saline solution or air, or by internal osmotic pressure generated by a hydrophilic polymer. In this study, a shell-free tissue expander comprised only of a chemically cross-linked biocompatible polymeric hydrogel is developed. The cross-linked network of hydrophilic polymer provides for intrinsically controlled swelling in the absence of an external membrane. The new type of hydrogel expanders were characterized in vitro as well as in vivo using a rat-skin animal model. It was found that increasing the hydrophobic polyester content in the hydrogel reduced the swelling velocity to a rate and volume that eliminate the danger of premature swelling rupturing the sutured area. Additionally, increasing the crosslinking density resulted in enough mechanical strength of the hydrogel to allow for complete post-swelling removal, without the hydrogel cracking or crumbling. No systemic toxicity was noted with the expanders and histology showed the material to be highly biocompatible. These expanders have an advantage of tissue expansion without requiring an external silicone membrane, and thus, they can be cut or reshaped at the time of implantation for applications in small or physically constrained regions of the body.

show abstract

Section: Resultssupporting

confidence: 57%

“…Triblock PLGA-PEG-PLGA diacrylate was synthesized as previously described [30–32]. Briefly, a PEG-diol of required molecular weight was obtained commercially (Sigma Aldrich) and dried under deep vacuum in a round bottom flask with stirring at 150 °C for 4 hours to remove water.…”

Section: Methodsmentioning

confidence: 99%

Reshapable polymeric hydrogel for controlled soft-tissue expansion: In vitro and in vivo evaluation

Garner

Davidson

Eckert

et al. 2017

Journal of Controlled Release

Self Cite

View full text Add to dashboard Cite

show abstract

“…23,31,33 They are, thus, considered as preferred vehicles for delivery of drugs [20][21][22]25,27,34 and other therapeutic agents. [35][36][37] We have previously reported the synthesis of a novel biodegradable triblock copolymer made of PEG and poly (fumaric acid-co-sebacoyl chloride) (PEG-co-P(FA/SC)-co-PEG) and its inertness against insulin, as a model therapeutic protein. 38,39 We hereby report on the formation and further characterization of these polymersomes, namely their shape and size by means of transmission electron microscopy (TEM), and dynamic light scattering as well as their stability at 25 o C (room temperature) and 37 o C (physiological temperature) by UV-vis spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Release Behavior of Polymersomes of PEG-Poly(fumaric-sebacic acids)-PEG Triblock Copolymer in Aqueous Solution

Pourhosseini¹,

Saboury²,

Najafi³

et al. 2013

Polymer Korea

View full text Add to dashboard Cite

Polymersomes made of biodegradable triblock copolymers based on poly(fumaric acid-co-sebacoyl chloride)/ PEG (PEG-co-P(FA/SC)-co-PEG) were prepared and studied in aqueous solutions. TEM confirmed the formation of vesicles in aqueous media. Aggregation behavior of the copolymers was studied by fluorescence spectroscopy of 8-anilino-1-naphthalenesulfonic acid, and the critical aggregation concentration (c.a.c.) of the copolymer was found to be ~26.2 µM indicating desirable stability of the vesicles. Dynamic light scattering revealed that the size of the vesicles was distributed within the range of 170-270 nm. Turbidity measurements confirmed the relative short-term stability of the polymersomes. Carboxyfluorescein, a hydrophilic compound, was simply encapsulated in the vesicles during polymersome preparation. The release of encapsulant from the polymersomes at 25 and 37 o C lasted about 3 weeks, and the rate of release followed a first-order kinetics. The release is speculated to be primarily carried out through diffusion. These results confirm that these polymersomes are promising as controlled-release carriers of various drugs.

show abstract

Preparation and Characterization of Biodegradable Hydrogels for Tissue Expander Application

Cited by 2 publications

References 0 publications

Reshapable polymeric hydrogel for controlled soft-tissue expansion: In vitro and in vivo evaluation

Reshapable polymeric hydrogel for controlled soft-tissue expansion: In vitro and in vivo evaluation

Characterization and Release Behavior of Polymersomes of PEG-Poly(fumaric-sebacic acids)-PEG Triblock Copolymer in Aqueous Solution

Contact Info

Product

Resources

About