Preparation and characterization of Betasitosterol-loaded nanostructured lipid carriers for butter enrichment

Bagherpour, Sevda; Alizadeh, Ainaz; Ghanbarzadeh, Saeed; Mohammadi, Maryam; Hamishehkar, Hamed

doi:10.1016/j.fbio.2017.07.010

Cited by 45 publications

(10 citation statements)

References 17 publications

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“…NLCs loaded with betasitosterol, a phytosterol showing beneficial effects on reducing total cholesterol and low-density lipoprotein (LDL), with particle size 165 nm, zeta potential −13.5 mV, and EE 99.96%, which were incorporated in butter, showed good stability during three months’ storage period and increased the antioxidant property of enriched butter during the storage period, suggesting the suitability of such nanoformulation for functional dairy products [ 207 ]. Multilayer CS–alginate–CUR NEs could be important for functional food development for combating obesity, because they increase satiety by retarding lipid digestion [ 143 ].…”

Section: Other Functional Applications Of Human Supplementsmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Food and Drug Administration, as well as by various national regulations issued most frequently by the Ministry of Health and/or the Ministry of Agriculture of particular countries around the world. They constitute a concentrated source of vitamins, minerals, polyunsaturated fatty acids and antioxidants or other compounds with a nutritional or physiological effect contained in the food/feed, alone or in combination, intended for direct consumption in small measured amounts. As nanotechnology provides “a new dimension” accompanied with new or modified properties conferred to many current materials, it is widely used for the production of a new generation of drug formulations, and it is also used in the food industry and even in various types of nutritional supplements. These nanoformulations of supplements are being prepared especially with the purpose to improve bioavailability, protect active ingredients against degradation, or reduce side effects. This contribution comprehensively summarizes the current state of the research focused on nanoformulated human and veterinary dietary supplements, nutraceuticals, and functional foods for special medical purposes, their particular applications in various food products and drinks as well as the most important related guidelines, regulations and directives.

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Section: Other Functional Applications Of Human Supplementsmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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“…Beta-sitosterol loaded lipid nanocarriers, showed good stability during three months' storage period Moreover, the use of this technique does not alter the texture and the organoleptic characteristics of the product [60] Echium oil and beta-sitosterol Arabic gum and gelatin Complex coacervation Yogurt Yogurt containing microcapsules did not show a significant difference in terms of physicochemical, rheological and sensorial properties with respect to control [61] Phytosterols mixture Whey protein isolate Spray drying Dark chocolates…”

Section: Hot Melt Homogenization Methods Buttermentioning

confidence: 99%

“…However, this step is fundamental for the production of new fortified food, because it allows both the evaluation of the stability and the acceptability of the final product. In this regard, Bagherpour et al [60] added encapsulated β-sitosterol in butter, since saturated fat consumption increases cardiovascular disease. For the encapsulation of β-sitosterol, it was used nanostructured lipid carriers, prepared by hot melt homogenization method.…”

Section: Use Of Microencapsulated Phytosterols For Functional Foods' mentioning

confidence: 99%

Microencapsulation as a Tool for the Formulation of Functional Foods: The Phytosterols’ Case Study

Tolve

Cela

Condelli

et al. 2020

Foods

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Hypercholesterolemia, which is an increase in total and low-density lipoprotein (LDL) serum cholesterol, is an important risk factor for the development of cardiovascular diseases. Lifestyle modifications underpin any action plan for reducing serum cholesterol. Phytosterols are natural compounds belonging to the triterpenes family. Thanks to their structural analogy with cholesterol, phytosterols have the ability to reduce serum LDL-cholesterol levels. Phytosterols are used to enrich or fortify a broad spectrum of food products. Like unsaturated fatty acids and cholesterol, phytosterols are easily oxidized. Microencapsulation could be a useful tool to overcome this and other drawbacks linked to the use of phytosterols in food fortification. In this review, in addition to explaining the phytosterols' mechanisms of action, a focus on the use of free and encapsulated phytosterols for the formulation of functional foods, taking also into account both technological and legislative issues, is given.

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“…NLCs are specially-designed to encapsulate hydrophobic compounds, since introducing a liquid lipid allows a better dispersion of the active substances and causes a decrease of the melting point compared to a pure solid lipid, and of defects in the crystal structure that prevent lipid polymorphism and avoid a perfect crystalline structure to provide more space for the active components. This also inhibits expulsion of the active substances to achieve greater drug loading and stability [ 45 , 48 , 49 , 53 , 54 , 55 , 56 ]. Other advantages of NLCs are that they present greater colloidal stability, due to the higher density of the solid lipid, they eliminate the need to use organic solvents during production, and they are less prone to changes in particle shape.…”

Section: Nanosystems As Components Of Edible Coatingsmentioning

confidence: 99%

“…Babazadeth et al [ 57 ] reported the use of NLCs in beverages like milk and juices (orange and apple), and elaborated models for studying physical changes, such as the effects of pH and temperature on the stability and turbidity of rutin-loaded NLCs. Bagherpour et al [ 54 ], meanwhile, studied the encapsulation of beta-sitosterol and its incorporation into butter to improve that food’s nutritional and antioxidant properties. Those research groups concluded that NLCs are a stable and suitable food-grade carrier for active substances that may be beneficial for future applications in the development of functional foods.…”

Section: Nanosystems In Edible Coatingsmentioning

confidence: 99%

Nanosystems in Edible Coatings: A Novel Strategy for Food Preservation

Zambrano-Zaragoza

González-Reza

Mendoza‐Muñoz

et al. 2018

IJMS

194

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Currently, nanotechnology represents an important tool and an efficient option for extending the shelf life of foods. Reducing particle size to nanometric scale gives materials distinct and improved properties compared to larger systems. For food applications, this technology allows the incorporation of hydrophilic and lipophilic substances with antimicrobial and antioxidant properties that can be released during storage periods to increase the shelf life of diverse products, including whole and fresh-cut fruits and vegetables, nuts, seeds, and cheese, among others. Edible coatings are usually prepared with natural polymers that are non-toxic, economical, and readily available. Nanosystems, in contrast, may also be prepared with biodegradable synthetic polymers, and liquid and solid lipids at room temperature. In this review, recent developments in the use of such nanosystems as nanoparticles, nanotubes, nanocomposites, and nanoemulsions, are discussed critically. The use of polymers as the support matrix for nanodispersions to form edible coatings for food preservation is also analyzed, but the central purpose of the article is to describe available information on nanosystems and their use in different food substrates to help formulators in their work.

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Preparation and characterization of Betasitosterol-loaded nanostructured lipid carriers for butter enrichment

Cited by 45 publications

References 17 publications

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Microencapsulation as a Tool for the Formulation of Functional Foods: The Phytosterols’ Case Study

Nanosystems in Edible Coatings: A Novel Strategy for Food Preservation

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