Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform

Abstract

The simple and functional modification of the nanoparticle’s surface is used to efficiently deliver chemotherapeutic drugs for anti-cancer treatment. Here, we construct a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes for the treatment of mouse breast cancer models. Compared with traditional free drug treatments, the biodegradable natural red blood cell membrane is combined with pure crystalline drugs. The nanoparticles obtained by the preparation method have superior properties, such as good stability, significantly delaying the release of drugs and enhancing the inhibitory effect on tumor cells. This study shows that the design of RBC as an outsourced drug delivery system provides a promising foundation for the continued development, clinical trials, and nanomedicine research of anti-cancer drug nanocarriers in the future.

Red Blood Cell Membrane-Camouflaged Polydopamine and Bioactive Glass Composite Nanoformulation for Combined Chemo/Chemodynamic/Photothermal Therapy

“…Additionally, nanoparticles encapsulated in red blood cell membranes (RBCms) offer a promising therapeutic strategy to reduce side effects by improving targeting, biocompatibility, somatic circulation, and drug accumulation in the tumor. − Recently, red blood cell membrane-encapsulated PDA nanocomplexes have been widely applied, including mesoporous PDA nanoparticles, intelligent nanocarriers, and multifunctional phototherapy platforms, which enhance drug delivery, enable combination therapy, mitigate hypoxia, and improve tumor imaging. − Various drug delivery systems, such as magnetic nanotubes, gold nanotubes, carbon nanotubes, biocompatible nanospheres, dendrimers, liposomes, and micelles, have been investigated for targeted cancer treatment . Notably, bioactive glass (BG) is commonly used in orthopedics and dentistry.…”

Drug Delivery Systems with a “Tumor-Triggered” Targeting or Intracellular Drug Release Property Based on DePEGylation

“…For example, cell membranes are one kind of common “stealthy” coating, due to their functions, such as intercellular communication, bioantifouling, immune defense, etc. [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], including, but not limited to, membranes isolated from erythrocyte [ 15 , 16 ], monocyte [ 17 ], macrophage [ 18 , 19 ], neutrophil [ 20 , 21 ], lymphocyte [ 22 , 23 ], and platelet [ 24 , 25 ], which have been reported to mimic cells for DDS protection [ 10 ]. Similarly, the exosomes or extracellular vesicles derived from cells are also important “stealthy” coatings [ 26 , 27 , 28 ].…”