Preparation and characterization of angiopep-2 functionalized Ginsenoside-Rg3 loaded nanoparticles and the effect on C6 Glioma cells

Su, Xiaomei; Zhang, Danshen; Zhang, Haiwei; Zhao, Kai; Hou, Wenshu

doi:10.1080/10837450.2018.1551901

Cited by 26 publications

(13 citation statements)

References 39 publications

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“…At present, there have been many mature drug delivery systems for brain targeting, such as nano-drug delivery systems, but most of them are macromolecular polymers, and mainly used to treat gliomas 25 , 26 . Polymer glue Bundles have been developed to treat cerebral ischemia–reperfusion injury 27 and liposome delivery systems have also been widely used in the treatment of gliomas 28 – 30 .…”

Section: Discussionmentioning

confidence: 99%

Dual targeting micelles loaded with paclitaxel and lapatinib for combinational therapy of brain metastases from breast cancer

Chen

Wang

et al. 2022

Sci Rep

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Due to the presence of the blood–brain barrier (BBB), the delivery of general drugs into the brain tissue remains to be a tricky problem. For patients with brain metastases from breast cancer, drug delivery systems must overcome this physical barrier. Targeted nano vehicles arise as a promising alternative to deliver drugs to brain tissues successively. Herein, a dual targeting micelle drug delivery system loaded with paclitaxel (PTX) and lapatinib (LPTN) was developed for combinational therapy of brain metastases. In our study, it was shown the micelles modified with Angiopep-2 had high loading efficiency of paclitaxel and lapatinib (Ang-MIC-PTX/LP). In addition, Ang-MIC-PTX/LP could transport across the in vitro BBB model and accumulate in breast cancer cells. After intravenous injection, Ang-MIC significantly accumulated in the brain metastasis. Ang-MIC-PTX/LP could also extend the life span of brain metastasis mouse models. Overall, this study provided a promising method for treatment of brain metastases from breast cancer.

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Section: Discussionmentioning

confidence: 99%

Dual targeting micelles loaded with paclitaxel and lapatinib for combinational therapy of brain metastases from breast cancer

Chen

Wang

et al. 2022

Sci Rep

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“…For example, a folic acid-modified targeting-drug delivery system based on bovine serum albumin nanoparticles achieved targeted accumulation of drugs at the cancer focus that significantly increased anti-cancer effectiveness of Rg5 in breast cancer ( Dong et al, 2019 ). Meanwhile, use of multiple nanoparticle-loaded Rg3 was shown to achieve good organ targeting, possess sustained release properties, and exert superior anti-cancer activities, while also facilitating transport of drugs across the blood-brain barrier ( Qiu et al, 2019 ; Ren et al, 2020 ; Su et al, 2020 ). These results support potential benefits of ginseng ingredients for use in numerous clinical applications.…”

Section: Discussionmentioning

confidence: 99%

Strategies for Remodeling the Tumor Microenvironment Using Active Ingredients of Ginseng—A Promising Approach for Cancer Therapy

Wang

et al. 2021

Front. Pharmacol.

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The tumor microenvironment (TME) plays a key role in promoting the initiation and progression of tumors, leading to chemoradiotherapy resistance and immunotherapy failure. Targeting of the TME is a novel anti-tumor therapeutic approach and is currently a focus of anti-tumor research. Panax ginseng C. A. Meyer (ginseng), an ingredient of well-known traditional Asia medicines, exerts beneficial anti-tumor effects and can regulate the TME. Here, we present a systematic review that describes the current status of research efforts to elucidate the functions and mechanisms of ginseng active components (including ginsenosides and ginseng polysaccharides) for achieving TME regulation. Ginsenosides have variety effects on TME, such as Rg3, Rd and Rk3 can inhibit tumor angiogenesis; Rg3, Rh2 and M4 can regulate the function of immune cells; Rg3, Rd and Rg5 can restrain the stemness of cancer stem cells. Ginseng polysaccharides (such as red ginseng acidic polysaccharides and polysaccharides extracted from ginseng berry and ginseng leaves) can regulate TME mainly by stimulating immune cells. In addition, we propose a potential mechanistic link between ginseng-associated restoration of gut microbiota and the tumor immune microenvironment. Finally, we describe recent advances for improving ginseng efficacy, including the development of a nano-drug delivery system. Taken together, this review provides novel perspectives on potential applications for ginseng active ingredients as anti-cancer adjuvants that achieve anti-cancer effects by reshaping the tumor microenvironment.

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“…5 ). Vascular endothelial cell-2 (angioep-2) polypeptides (ANG) also have been utilized to prepare NPs to load therapeutic macromolecules Rg3 [ 89 ]. Interestingly, ANG-Rg3-NP with a particle size of 147.1 ± 2.7 nm showed good sustained-release behavior, which inhibited the proliferation of C6 glioma cells in a concentration-dependent manner, while angioprep-2-functionalized NPs were easier to cross the BBB and accelerated the uptake of NPs by cells.…”

Section: Ginsenosides As Bifunctional Drugs and Nanocarriers In Ddssmentioning

confidence: 99%

“…Among them, the amino acid (mPEG-b-P (Glu-co-Phe)) NPs can target cancer cells owing to pH sensitivity and have a longer circulation time in the blood [ 88 ]. In addition, ANG-Rg3-NP modified with vascular endothelial cell-2 (angioep-2) polypeptide has shown good sustained-release behavior and inhibited the proliferation of C6 glioma cells in a concentration-dependent manner, while angioprep-2-functionalized NPs crossed the BBB more easily and accelerated their cell uptake [ 89 ]. Furthermore, the fluidity of the cuticle lipid was increased by the cross-action of alcohol on the lipid bilayer to enhance the skin penetration of the drug.…”

Section: Encapsulated Ginsenosides Improve Biological Functionsmentioning

confidence: 99%

Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies

et al. 2021

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Ginsenosides, the main components isolated from Panax ginseng, can play a therapeutic role by inducing tumor cell apoptosis and reducing proliferation, invasion, metastasis; by enhancing immune regulation; and by reversing tumor cell multidrug resistance. However, clinical applications have been limited because of ginsenosides’ physical and chemical properties such as low solubility and poor stability, as well as their short half-life, easy elimination, degradation, and other pharmacokinetic properties in vivo. In recent years, developing a ginsenoside delivery system for bifunctional drugs or carriers has attracted much attention from researchers. To create a precise treatment strategy for cancer, a variety of nano delivery systems and preparation technologies based on ginsenosides have been conducted (e.g., polymer nanoparticles [NPs], liposomes, micelles, microemulsions, protein NPs, metals and inorganic NPs, biomimetic NPs). It is desirable to design a targeted delivery system to achieve antitumor efficacy that can not only cross various barriers but also can enhance immune regulation, eventually converting to a clinical application. Therefore, this review focused on the latest research about delivery systems encapsulated or modified with ginsenosides, and unification of medicines and excipients based on ginsenosides for improving drug bioavailability and targeting ability. In addition, challenges and new treatment methods were discussed to support the development of these new tumor therapeutic agents for use in clinical treatment.

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Preparation and characterization of angiopep-2 functionalized Ginsenoside-Rg3 loaded nanoparticles and the effect on C6 Glioma cells

Cited by 26 publications

References 39 publications

Dual targeting micelles loaded with paclitaxel and lapatinib for combinational therapy of brain metastases from breast cancer

Dual targeting micelles loaded with paclitaxel and lapatinib for combinational therapy of brain metastases from breast cancer

Strategies for Remodeling the Tumor Microenvironment Using Active Ingredients of Ginseng—A Promising Approach for Cancer Therapy

Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies

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