Preparation and characterization of a novel conformed bipolymer paclitaxel-nanoparticle using tea polysaccharides and zein

Li, Shuqin; Wang, Xiuming; Li, Weiwei; Yuan, Guoqi; Pan, Ying‐Ming; Chen, Hạixia

doi:10.1016/j.carbpol.2016.03.042

Cited by 50 publications

(16 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The products showed ab road band at ñ = 3404 cm À1 ,w hich was assigned to the stretching vibration modes of ÀOH groups and inter-and intramolecular hydrogen bonds. [80][81][82][83][84][85][86][87][88] Ac omparison between the FTIR spectra of LS with CELS showedt hat there was a strong sharp absorption at ñ = 1595 cm À1 in the spectrumo f CELS, which corresponded to C=Os tretching. [80,82,87,91] This observation indicated clearly that CELS contained considerably more carboxyl functional groups than LS.…”

Section: Ftir Spectroscopymentioning

confidence: 99%

“…Additionally,t he resultsp resented in Ta ble 4r eveal that the impact of the optimal factor levels for molecular weight shouldb eT (80 8C) > t (0.5 h) > C 3 H 5 ClO 2 /LS ð2:0mol mol À1 Þ = C 3 H 5 ClO 2(0.03 mol) > NaOH (20 wt %) ,w hich was also not among the 16 runs given in Table 3. Therefore, in addition to 16 options, 3450, [81] 3421, [82] 3439, [83] 3419, [84] 3434, [85] 3360, [86] 3429, [87] [3410-3460] [88] OÀHs tretching vibration in phenolic and aliphatic compounds 22 932…”

Section: Rangea Nalysismentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and Characterization of Carboxyethylated Lignosulfonate

Bahrpaima

Fatehi

2018

ChemSusChem

View full text Add to dashboard Cite

Lignosulfonate is a byproduct of the sulfite pulping process and has limited use in industry. The main objective of this study was to investigate the carboxyethylation of lignosulfonate to increase its charge density to broaden its applications. The carboxyethylation of lignosulfonate was optimized under the conditions of 30 wt % NaOH, 2.0 mol mol 2-chloropropinic acid/lignosulfonate, 90 °C, 0.5 h, and 0.03 mol 2-chloropropinic acid, which produced carboxyethylated lignosulfonate with a charge density and molecular weight of -3.51 meq g and 46 493 g mol , respectively. The mechanism of the carboxyethylation reaction using 2-chloropropinic acid by an S 1 pathway in an alkaline solution was discussed. Methylation was also used to mask the phenolic hydroxide groups of lignosulfonate to investigate if carboxyethylation occurred on aliphatic hydroxide groups of lignosulfonate. The produced carboxyethylated lignosulfonate was characterized by using FTIR spectroscopy, NMR spectroscopy, gel permeation chromatography, and elemental and functional group analyses. Basic H- H 2 D COSY NMR spectroscopy was used to record the coupled spins of the carboxyethyl group on carboxyethylated lignosulfonate. The information from 1 D H NMR and 2 D NMR COSY spectroscopy provided evidence for the existence of a 1-carboxyethyl group on the carboxyethylated lignosulfonate structure.

show abstract

Section: Ftir Spectroscopymentioning

confidence: 99%

Section: Rangea Nalysismentioning

confidence: 99%

Synthesis and Characterization of Carboxyethylated Lignosulfonate

Bahrpaima

Fatehi

2018

ChemSusChem

View full text Add to dashboard Cite

show abstract

“…Zein is a hydrophobic and water‐insoluble biopolymer originated from corn plant. Zein capability as microspheres and nanospheres to entrap various bioactive molecules and deliver different types of drugs and macromolecules is well documented . Moreover, zein intrinsic hydrophobicity makes it a favorable polymer for NP synthesis by anti‐solvent precipitation method.…”

Section: Introductionmentioning

confidence: 99%

Zein nanoparticle‐embedded electrospun PVA nanofibers as wound dressing for topical delivery of anti‐inflammatory diclofenac

Ghalei

Asadi

Ghalei

2018

J of Applied Polymer Sci

View full text Add to dashboard Cite

Bioactive wound dressings from poly(vinyl alcohol) (PVA) and zein nanoparticles (NPs) loaded with diclofenac (DLF) were prepared successfully by the single jet electrospinning method. DLF‐loaded zein NPs with an average diameter of ∼228 nm were prepared using anti‐solvent precipitation method. The formulation of zein:DLF 1:1 exhibited optimum encapsulation efficiency of 47.80%. The NPs were characterized by dynamic light scattering, zeta‐potential measurement, and differential scanning calorimetry. In vitro, drug release profiles of the DLF‐loaded zein NPs, and PVA–zein NPs were also studied within 120 h and showed the release efficiency of nearly 80% from zein NPs. A more controlled release of DLF was achieved by embedding the zein NPs in the PVA nanofibers. Fourier transform infrared spectroscopy was used to analyze possible interactions between different components of the fabricated dressings. The mechanical properties of the developed dressings were also evaluated using uniaxial tensile testing. Young's modulus (E) of the dressings decreased after inclusion of zein NPs within the PVA nanofibers. Moreover, fibroblast culturing experiments proved that the composite dressings supported better cell attachment and proliferation compared to PVA nanofibers, by exhibiting moderate hydrophilicity. The results suggested that the electrospun composite dressing of PVA nanofibers and zein NPs is a promising topical drug‐delivery system and have a great potential for wound healing application. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46643.

show abstract

“…The absorption peaks at 1747 and 1442 cm −1 were the characteristic absorptions of uronic acid, which indicated TPS was acidic polysaccharides (Wang et al ., ). The peak at around 1644 cm −1 was attributed to N‐H vibration of amide, which showed the existence of protein in TPS (Li et al ., ). The band of absorbance at 1325 cm −1 was resulted from O‐H vibration absorption.…”

Section: Resultsmentioning

confidence: 97%

“…It was reported that the molecular weight distribution of TPS was ranged from 0.4 9 10 4 to 40.5 9 10 4 Da, and it was composed of rhamnose, arabinose, mannose, glucose, galactose and uronic acid (Zhang et al, 2013). TPS has attracted much attention due to its various bioactivities, such as antioxidant, immunomodulatory, hypoglycaemic, hypolipidaemic and anticancer activities (Li et al, 2016). In particular, as natural hypoglycaemic functional food or alternative medicine, TPS was shown an effective inhibitor towards a-amylase in the range of 65-82% (Wang et al, 2010;Xiao et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical characterisation and α‐amylase inhibitory activity of tea polysaccharides under simulated salivary, gastric and intestinal conditions

Wang

Yuan

et al. 2017

Int J of Food Sci Tech

Self Cite

View full text Add to dashboard Cite

Summary Tea polysaccharides (TPS) are one of the main components of tea with various bioactivities. Digestion could result in the changes of the physicochemical properties and bioactivities of polysaccharides. The objective of this study was to determine the changes in physicochemical properties and α‐amylase inhibitory activities of TPS after simulated digestion. The structure of TPS determined by UV, IR and SEM showed that no obvious changes after salivary digestion, but significant changes after gastrointestinal digestion were observed. After intestinal digestion, the contents of reducing sugar were increased from 0.650 ± 0.011 to 1.594 ± 0.078 mm, and the centre molecular weight was decreased from 540.57 to 375.35 KDa. The molar ratio of monosaccharide was changed after digestion. And α‐amylase inhibition rate was significantly increased (P < 0.05). The results could provide information on the digestibility of TPSin vitro and contribute to the development of related functional foods or medicines.

show abstract

Preparation and characterization of a novel conformed bipolymer paclitaxel-nanoparticle using tea polysaccharides and zein

Cited by 50 publications

References 25 publications

Synthesis and Characterization of Carboxyethylated Lignosulfonate

Synthesis and Characterization of Carboxyethylated Lignosulfonate

Zein nanoparticle‐embedded electrospun PVA nanofibers as wound dressing for topical delivery of anti‐inflammatory diclofenac

Physicochemical characterisation and α‐amylase inhibitory activity of tea polysaccharides under simulated salivary, gastric and intestinal conditions

Contact Info

Product

Resources

About